Enhancing singlet oxygen generation in semiconducting polymer nanoparticles through fluorescence resonance energy transfer for tumor treatment

Abstract

We have developed semiconducting polymer nanoparticle-based photosensitizers for O2mapping and enhanced the PDT effect by using fluorescence resonance energy transfer.

Architectures and Applications of BODIPY-Based Conjugated Polymers

“…Interestingly, taking advantage of the linear relationship between the phosphorescence lifetime of NPs or the emission Recently, multifunction dyes have been highlighted for biological applications, especially the dyes that have both bioimaging and biotherapy capabilities. Zhao and coworkers [94] proposed a new ionized polyfluorene 65 conjugated with BODPIYs and NIR phosphorescent iridium(III) complexes, and polymers 66 and 67 containing fluorene and BODIPYs or iridium(III) complexes respectively, as control groups (Figure 22). Consequently, the authors could investigate the FRET process between BODIPYs donor and iridium(III) complexes acceptor.…”

“…A significant amount of effort has been channeled toward the development of specific imaging and effective therapies, where BODIPY-based conjugated polymers have ample scope due to their high expansibility of optical properties [ 64 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 ]. Fluorescence imaging can help to provide visualized results with simple operation and low cost.…”

“… Chemical structures of polymers 65 – 67 and graphical representation of 65 used as photosensitizers with enhanced 1 O 2 generation through Förster resonant energy transfer (FRET) for efficient tumor treatment (Reproduced with permission from Reference [ 94 ]. Copyright @ 2019 Royal Society of Chemistry).…”

New Approach in the Application of Conjugated Polymers: The Light-Activated Source of Versatile Singlet Oxygen Molecule

“…In order to reduce the side effects and minimize the damage of the normal tissues, the generation of 1 O 2 should be precise and controllable. This can be achieved by introduction of pH-, polarity- or wavelength-sensitive systems [ 48 , 49 ]. Since PDT cancer therapy is based on the light-activated process, the penetration of light through tissues has to be considered.…”

Development of a novel anti-tumor theranostic platform: a near-infrared molecular upconversion sensitizer for deep-seated cancer photodynamic therapy

“…The enhanced ISC ability subsequently promoted the production of cytotoxic singlet oxygen ( 1 O 2 ). [38][39][40][41][42] Different from conventional Stokes excitation, the one-photon driven upconversion process of FUCP-1 is induced by 808 nm excitation from the thermally excited vibrational-rotational energy sublevels of the ground electronic state S t to S 1 and the additional energy is supplied by the heat derived from the Boltzmann distribution of molecules. [43][44][45][46][47] Notably, FUCP-1 exhibited an excellent upconversion luminescence quantum yield (>12%) and outstanding photostability under 808 nm laser irradiation compared to Stokes excitation (700 nm).…”