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Cited by 5 publications
(6 citation statements)
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References 7 publications
(8 reference statements)
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“…In contrast, in p53 mut cells, GFI1 is only protecting the cells via S1P modulation. Taken together, our data are in agreement with previous work that suggested sphingolipid modulation is a very plausible therapeutic strategy for MM [52].…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…In contrast, in p53 mut cells, GFI1 is only protecting the cells via S1P modulation. Taken together, our data are in agreement with previous work that suggested sphingolipid modulation is a very plausible therapeutic strategy for MM [52].…”
Section: Discussionsupporting
confidence: 93%
“…This suggests that modulation of the S1P signaling pathway was significantly associated with genes bound by GFI1, although these were not B cell lineage cells. An ENCODE analysis of DNase hypersensitivity for 95 cell types across the genome and use of an ENCODE algorithm that predicts candidate Cis-Regulatory Elements together revealed multiple putative regulatory regions within the promoter and along ~3 Kb of the 5 end (exon 1 and a small part of intron 1) of the ~43.6 Kb SGPP1 gene body [50][51][52][53][54][55][56][57][58][59][60][61] (Figure S3A). Thus, to scan for GFI1 occupancy on the SGPP1 gene in MM cells over a large region (~3 Kb) of the SGPP1 locus (Figure 5A), we performed an initial broad-resolution GFI1 ChIP-qPCR screen using a 500 bp chromatin fragmentation of fixed chromatin from MM cell lines MM.1S (p53 WT) and OPM-2 (p53 mut) GFI1 o/e and their EV controls (Table S4).…”
Section: Gfi1-dependent Survival Of MM Cells Is Mediated By Intracell...mentioning
confidence: 99%
“…Conversely, the combination of fenofibrate and ixazomib failed to prevent MM cell growth in mice. Although the antitumour activity of fenofibrate, particularly its antiproliferative effect on MM cells, has been recognized (Schmeel et al, 2017), and although fenofibrate was intended to be applied in clinical trials for MM Pitson, 2017). This study confirmed that the level of ATF4, an important effector of the UPR, was substantially increased upon proteasome inhibition (Figure 5a,b).…”
Section: Discussionsupporting
confidence: 65%
“…Recent data demonstrated an enrichment of NRF2 and endoplasmic reticulum (ER) pathways in response to alkylating agents in solid cancers [52]. Since the high level of immunoglobulin secretion requires folding in the ER lumen, the influence of NRF2 and ER homeostasis could be of interest to target MM cells [53].…”
Section: Discussionmentioning
confidence: 99%