Enhancing diabetic wound healing with a pH/glucose dual-responsive hydrogel for ROS clearance and antibacterial activity

Hao, Jie; Liu, Chengxiang; Zhou, Ling; Wu, Nan; Sun, Mengyi; Kuang, Jianren; Pan, Hang; Lian, Yu; Li, Jing; Dong, Yan; Cheng, Liqing

doi:10.1016/j.ijbiomac.2024.132935

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.132935

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Enhancing diabetic wound healing with a pH/glucose dual-responsive hydrogel for ROS clearance and antibacterial activity

Jie Hao,

Chengxiang Liu,

Ling Zhou

et al.

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2024

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Cited by 2 publications

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Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing

Astaneh,

Hashemzadeh,

Fereydouni

2024

J. Mater. Chem. B

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Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing

Astaneh,

Hashemzadeh,

Fereydouni

2024

J. Mater. Chem. B

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Composite Polysaccharide Hydrogel Loaded with Scutellaria baicalensis Extract for Diabetic Wound Treatment

Zhu,

Li,

Wang

et al. 2024

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Diabetic wounds present significant burdens to both patients and the healthcare system due to their prolonged inflammatory phase and adverse microenvironment. Traditional Chinese medicine (TCM), particularly Scutellaria baicalensis extract (SE), has shown promise in wound healing. Herein, sesbania gum (SG) was oxidized and formed hydrogel with carboxymethyl chitosan (CMCS) through the imine bond. Then, SE was loaded into the hydrogel as a wound dressing (CMCS−OSG@SE hydrogel). In vitro experiments demonstrated the mechanical properties and ROS scavenging efficiency of the hydrogel, as well as the release of SE and its biocompatibility. In an vivo study, diabetic mice with S. aureus infection were used, and the CMCS−-OSG@SE hydrogel dressing accelerated wound healing by promoting epidermal regeneration and collagen deposition. This composite polysaccharide hydrogel loaded with SE shows great potential for diabetic wound treatment.

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Enhancing diabetic wound healing with a pH/glucose dual-responsive hydrogel for ROS clearance and antibacterial activity

Cited by 2 publications

References 33 publications

Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing

Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing

Composite Polysaccharide Hydrogel Loaded with Scutellaria baicalensis Extract for Diabetic Wound Treatment

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