Enhancing Cellular Internalization of Single-Chain Polymer Nanoparticles via Polyplex Formation

Hamelmann, Naomi M.; Uijttewaal, Sjoerd; Hujaya, Sry D.

doi:10.1021/acs.biomac.2c00858

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…Binder and co-workers developed near-infrared (NIR)-fluorescent SCNPs that change their photophysical behavior upon heating and generate a fluctuating photoacoustic (PA) signal which can be used as a novel effect for PA imaging. Moreover, Paulusse and co-workers showed rapid uptake by HeLa cancer cells of SCNPs via polyplex formation and cytosolic delivery of doxorubicin from the SCNPs acting as nanocarriers. For recent reviews about the full range of possibilities SCNPs offer in different applications, we refer the reader to previous studies. − …”

Section: Introductionmentioning

confidence: 99%

Trimethylsilanol Cleaves Stable Azaylides As Revealed by Unfolding of Robust “Staudinger” Single-Chain Nanoparticles

Blázquez-Martín,

Bonardd,

Verde-Sesto

et al. 2024

ACS Polym. Au

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Herein, we disclose a unique and selective reagent for the cleavage of stable azaylides prepared by the nonhydrolysis Staudinger reaction, enabling the on-demand unfolding of robust single-chain nanoparticles (SCNPs). SCNPs with promising use in catalysis, nanomedicine, and sensing are obtained through intrachain folding of discrete synthetic polymer chains. The unfolding of SCNPs involving reversible interactions triggered by a variety of external stimuli (e.g., pH, temperature, light, and redox potential) or substances (e.g., competitive reagents, solvents, and anions) is well known. Conversely, methods for the unfolding (i.e., intrachain disassembly) of SCNPs with stronger covalent interactions are scarce. We show that trimethylsilanol (Me 3 SiOH) triggers the efficient unfolding of robust "Staudinger" SCNPs with stable azaylide (−N�P−) moieties as intrachain cross-linking units showing exceptional stability toward water, air, and CS 2 , a standard reagent for azaylides. As a consequence, Me 3 SiOH arises as a rare, exceptional, and valuable reagent for the cleavage of stable azaylides prepared by the nonhydrolysis Staudinger reaction.

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Section: Introductionmentioning

confidence: 99%

Trimethylsilanol Cleaves Stable Azaylides As Revealed by Unfolding of Robust “Staudinger” Single-Chain Nanoparticles

Blázquez-Martín,

Bonardd,

Verde-Sesto

et al. 2024

ACS Polym. Au

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show abstract

“…Enzyme-like, compartmentalized nanostructures of different philicities can be produced by using amphiphilic precursor polymers for single-chain crosslinking. [11][12][13] Inside these structures, small molecules like catalysts, [14][15][16] drugs, [17][18][19][20] or (fluorescent) dyes [21][22][23][24][25] can be encapsulated, by binding either non-covalently like in a unimolecular micelle, or covalently directly to the SCNP.…”

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confidence: 99%