Enhancing Ablation Effects of a Microbubble-Enhancing Contrast Agent (“SonoVue”) in the Treatment of Uterine Fibroids With High-Intensity Focused Ultrasound: A Randomized Controlled Trial

Jiang, Nan; Xie, Bin; Zhang, Xin; He, Miao; Li, Kequan; Bai, Jing; Wang, Zhibiao; He, Jia

doi:10.1007/s00270-013-0803-z

Cited by 37 publications

(31 citation statements)

References 22 publications

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“…Kennedy et al have used CEUS to evaluate the extent of ablation after HIFU treatment of liver tumor [8]. Recently, some studies showed that SonoVue may play a role in enhancing the effect of HIFU ablation for uterine fibroids [19,20]. However, to the best of our knowledge, no one has compared the intraprocedure CEUS results of HIFU with that of MRI.…”

Section: Discussionmentioning

confidence: 95%

Intraprocedure contrast enhanced ultrasound: The value in assessing the effect of ultrasound-guided high intensity focused ultrasound ablation for uterine fibroids

Song

Chen

et al. 2015

Ultrasonics

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Section: Discussionmentioning

confidence: 95%

Intraprocedure contrast enhanced ultrasound: The value in assessing the effect of ultrasound-guided high intensity focused ultrasound ablation for uterine fibroids

Song

Chen

et al. 2015

Ultrasonics

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“…10,11 Based on the results of the experimental study, we performed a clinical study to investigate which time point after administration of SonoVue is the most effective and safest in the treatment of uterine fibroids with HIFU. In this study, we started to treat patients at 1, 3 or 5 minutes after administration of SonoVue.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 Briefly, every patient was carefully positioned prone on the HIFU table. The anterior abdominal wall was in contact with degassed water.…”

Section: Usghifu After Administration Of Sonovuementioning

confidence: 99%

“…[4][5][6][7] As microbubbles can change the acoustic properties of tissues and thus increase the efficacy of HIFU treatment, many experimental studies have investigated the enhancing effects of microbubbles on HIFU treatment. 8,9 Peng et al 10 and Jiang et al 11 have demonstrated that SonoVue can be safely used to enhance the ablation effects of HIFU for uterine fibroids. But in those studies, HIFU sonication began 5 or 10 minutes after the administration of SonoVue.…”

Section: Introductionmentioning

confidence: 99%

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Enhancing ablation effects of a microbubble contrast agent on high‐intensity focused ultrasound: an experimental and clinical study

Cheng

Xiao

Huang

et al. 2017

BJOG

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Objective To investigate the relationship between SonoVue ablation enhancement effects on high-intensity focused ultrasound (HIFU) and the concentration of SonoVue and timing of HIFU.Design Two randomised controlled trials.Setting An animal centre in a university and a gynaecological department in a university hospital in China.Population or sample 63 rabbits and 143 patients with a solitary uterine fibroid.Methods Among the 63 rabbits, three were assigned to the control group. The other 60 were evenly assigned to three study groups pretreated with 0.03, 0.05 or 0.07 ml/kg of SonoVue before HIFU treatment. Two points in each liver were selected to be treated with HIFU and sonication started at 10, 30, 60, 90, 120, 150, 180, 210, 250 or 300 seconds after the administration of SonoVue, respectively. The 143 patients with solitary uterine fibroids were assigned to four groups: 30 patients were treated using only HIFU; the other patients were pretreated with same dosage of SonoVue and 32, 38 and 43 were treated with HIFU at 1-, 3-, and 5-minutes after administration of SonoVue, respectively.Main outcome measures The relation between SonoVue ablation enhancement effects on HIFU and the concentration of SonoVue and timing of HIFU.Results In the experimental study, the highest temperature and the largest necrotic volume in the liver were observed when HIFU sonication started at 60 seconds after administration of SonoVue. In the clinical study, the rate of significant grey-scale changes in the 1-minute SonoVue group was significantly greater than in the other three groups. The sonication time to reach massive greyscale changes measured in the 1-minute SonoVue group was significantly shorter than in in the other three groups. The sonication time for ablating 1 cm 3 of fibroid volume in the 1-minute SonoVue group was significantly shorter than in the other three groups. The acoustic energy used in treating 1 mm 3 of uterine fibroid in the 1-minute SonoVue group was significantly less than that used in the other three groups. No major complications occurred in this study.Conclusions SonoVue could safely be used to enhance the ablation effects of HIFU treatment, and the optimal time to begin HIFU sonication seems to be 1 minute after the administration of SonoVue.Keywords Enhancing effects, high-intensity focused ultrasound, rabbit liver, SonoVue, uterine fibroids.Tweetable abstract SonoVue, a microbubble contrast agent, enhanced the ablation effects of HIFU treatment; the optimal time to begin HIFU sonication appears to be 1 minute after the administration of SonoVue.

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“…Thus, the authors suggested that the encapsulated MBs enhanced the outcome of HIFU ablation and can be used to assess the extent of treatment. In a similar study, Jiang et al (2014) evaluated the clinical value of encapsulated MBs in the treatment of uterine fibroids with HIFU ablation in patients with a history of pelvic operation. A total of 80 patients with solitary uterine fibroids at a single center were randomly assigned to a control or SonoVue group (half-and-half) and were treated with HIFU.…”

Section: Preclinical Evaluation Of Cavitation-enhanced Thermal Effectsmentioning

confidence: 99%

Cavitation-Enhanced Thermal Effects and Applications

Zhang

Wan

Haar

2015

Cavitation in Biomedicine

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Enhancing Ablation Effects of a Microbubble-Enhancing Contrast Agent (“SonoVue”) in the Treatment of Uterine Fibroids With High-Intensity Focused Ultrasound: A Randomized Controlled Trial

Abstract: Based on the results of this randomized controlled trial, SonoVue could be safely used to enhance the effects of HIFU treatment for uterine fibroids.

Cited by 37 publications

References 22 publications

Intraprocedure contrast enhanced ultrasound: The value in assessing the effect of ultrasound-guided high intensity focused ultrasound ablation for uterine fibroids

Intraprocedure contrast enhanced ultrasound: The value in assessing the effect of ultrasound-guided high intensity focused ultrasound ablation for uterine fibroids

Enhancing ablation effects of a microbubble contrast agent on high‐intensity focused ultrasound: an experimental and clinical study

Cavitation-Enhanced Thermal Effects and Applications

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