Enhancement of the photodynamic effects on human oral squamous cell carcinoma cell lines by treatment with calcipotriol

Topical calcipotriol before ablative fractional laser-assisted photodynamic therapy enhances treatment outcomes for actinic keratosis in Fitzpatrick grades III-V skin: A prospective randomized clinical trial

“…Topical calcipotriol promotes cell differentiation, apoptosis, and increases the efficacy of PDT by enhancing the activity of coproporphyrinogen oxidase in the heme biosynthetic pathway, promoting the accumulation of PpIX. 5 This study was limited by short follow-up, inclusion of patients from only 1 ethnic group, and lack of control for lifestyle factors, such as individual vitamin-D intake, nutritional factors, and physical activity. Therefore, these results require further verification.…”

Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells

“…Cellular differentiation leads to increased synthesis of PpIX from exogenous ALA, 7 and consecutively, differentiation therapy enhances lethal photosensitization 8 . Calcitriol [vitamin D derivative, 1,25(OH) 2 D 3 ] is a well‐known prodifferentiation hormone and was demonstrated to influence the effect of PDT on several cell lines, including keratinocytes 7–10 . Thus, our purpose is to investigate if calcitriol has a similar effect on SCC cells, and to find out if it can enhance the efficacy of PDT on poorly differentiated malignant cells.…”

Estudos fotofísicos, fotoquímicos e fotobiológicos de porfirinas e ftalocianinas derivadas de éter de coroa

“…No Brasil, a técnica da TFD vem sendo estudada desde 1995 pelo grupo de Pesquisa em Fotobiologia e Fotomedicina da FFCLRP-USP, na pesquisa de novos sistemas de liberação de fármacos (Nunes , Sguilla e Tedesco, 2004a) e FSs aplicados à TFD (Rotta , Lunardi e Tedesco, 2003a;Tedesco et al, 2003;Tedesco , Rotta e Lunardi, 2003a (Costa et al, 2005;Tedesco et al, 2003;Turchiello et al, 2003 (Akita et al, 2007;Brown et al, 2007;Donnelly et al, 2007;Kaiserman et al, 2007;Moore et al, 2007;Selman, 2007;van der Maulen et al, 2007 →S 0 ser proibida por spin (Sharman , Allen e vanLier, 2000). Dessa forma o fotossensibilizador no estado T 1 pode interagir fotoquimicamente com moléculas de oxigênio, ou biomoléculas localizadas próximas a região irradiada, gerando espécies reativas que danificam o tecido irradiado (Gorman et al, 2004;Oleinick , Morris e Belichenko, 2002;van Nostrum, 2004).…”