Enhancement of Glutamate Release by l-Fucose Changes Effects of Glutamate Receptor Antagonists on Long-Term Potentiation in the Rat Hippocampus

Matthies, H; Schroeder, Helmut; Smalla, Karl‐Heinz; Krug, Manfred

doi:10.1101/lm.7.4.227

Cited by 18 publications

(10 citation statements)

References 47 publications

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“…There are several articles describing some mechanisms that may be partially responsible for the effects of 2´-FL or Fuc on synaptic function [18, 34]. Injected L-fucose may have an influence on glutamate release at the hippocampal CA3-CA1 synapse [35]. Moreover, glycosylation of proteins during a critical time window following HFS of hippocampal slices is necessary for the adequate induction as well as maintenance of the evoked LTP [36], demonstrating the importance of Fuc residues in the frame of adequate neuronal processing.…”

Section: Discussionmentioning

confidence: 99%

Dietary 2’-Fucosyllactose Enhances Operant Conditioning and Long-Term Potentiation via Gut-Brain Communication through the Vagus Nerve in Rodents

et al. 2016

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2´-fucosyllactose (2´-FL) is an abundant human milk oligosaccharide (HMO) in human milk with diverse biological effects. We recently reported ingested 2´-FL stimulates central nervous system (CNS) function, such as hippocampal long term potentiation (LTP) and learning and memory in rats. Conceivably the effect of 2´-FL on CNS function may be via the gut-brain axis (GBA), specifically the vagus nerve, and L-fucose (Fuc) may play a role. This study had two aims: (1) determine if the effect of ingested 2´-FL on the modulation of CNS function is dependent on the integrity of the molecule; and (2) confirm if oral 2´-FL modified hippocampal LTP and associative learning related skills in rats submitted to bilateral subdiaphragmatic vagotomy. Results showed that 2´-FL but not Fuc enhanced LTP, and vagotomy inhibited the effects of oral 2´-FL on LTP and associative learning related paradigms. Taken together, the data show that dietary 2´-FL but not its Fuc moiety affects cognitive domains and improves learning and memory in rats. This effect is dependent on vagus nerve integrity, suggesting GBA plays a role in 2´-FL-mediated cognitive benefits.

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Section: Discussionmentioning

confidence: 99%

Dietary 2’-Fucosyllactose Enhances Operant Conditioning and Long-Term Potentiation via Gut-Brain Communication through the Vagus Nerve in Rodents

et al. 2016

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“…More recently, the epitope Fucα(1-2)Gal has been revealed as a key regulator of neurite outgrowth and synapse formation and maintenance [42,44]. Furthermore, it has been reported that L-fucose increased glutamate release and interfered with competitive glutamate receptor antagonists when applied to hippocampal slices [40].…”

Section: '-Fl Effects On Expression Of Selected Neural Function Markersmentioning

confidence: 98%

“…Among other mechanisms [17,39], injected L-fucose may have an influence on glutamate release at the hippocampal CA3-CA1 synapse [40]. In addition, it has been reported that glycosylation of proteins during a critical time window following HFS of hippocampal slices is…”

Section: '-Fl Effects On Ltp Evoked At Hippocampal Synapsesmentioning

confidence: 99%

Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents

Vázquez

Barranco

Ramírez

et al. 2015

The Journal of Nutritional Biochemistry

135

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“…These suggestions are supported for 2’FL by our observations with video recordings showing decreased frequency, reduction of amplitude and velocity of colonic motor contractions. Since the effects of fucosylated oligosaccharides clearly occur through interactions, directly or indirectly with the ENS, we speculate that they could well also be exerting a positive effect on the brain via the vagus nerve [45,46] in supporting cognition and memory [47,48]. …”

Section: Discussionmentioning

confidence: 99%

Fucosylated but Not Sialylated Milk Oligosaccharides Diminish Colon Motor Contractions

et al. 2013

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Human milk oligosaccharides (HMO) are being studied by different groups exploring a broad range of potential beneficial effects to the breastfed infant. Many of these effects have been attributed to a growth promotion effect on certain gut organisms such as bifidobacteria. Additionally, evidence indicates that HMO are able to directly promote positive changes in gut epithelium and immune responses under certain conditions. This study utilizes a standardized ex vivo murine colon preparation to examine the effects of sialylated, fucosylated and other HMO on gut motor contractions. Only the fucosylated molecules, 2’FL and 3’FL, decreased contractility in a concentration dependent fashion. On the basis of IC50 determinations 3’FL was greater than 2 times more effective than 2’FL. The HMO 3’SL and 6’SL, lacto-N-neotetraose (LNnT), and galactooligosaccharides (GOS) elicited no effects. Lactose was used as a negative control. Fucosylation seems to underlie this functional regulation of gut contractility by oligosaccharides, and L-fucose, while it was also capable of reducing contractility, was substantially less effective than 3’FL and 2’FL. These results suggest that specific HMO are unlikely to be having these effects via bifidogenesis, but though direct action on neuronally dependent gut migrating motor complexes is likely and fucosylation is important in providing this function, we cannot conclusively shown that this is not indirectly mediated. Furthermore they support the possibility that fucosylated sugars and fucose might be useful as therapeutic or preventative adjuncts in disorders of gut motility, and possibly also have beneficial central nervous system effects.

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Enhancement of Glutamate Release by l-Fucose Changes Effects of Glutamate Receptor Antagonists on Long-Term Potentiation in the Rat Hippocampus

Cited by 18 publications

References 47 publications

Dietary 2’-Fucosyllactose Enhances Operant Conditioning and Long-Term Potentiation via Gut-Brain Communication through the Vagus Nerve in Rodents

Dietary 2’-Fucosyllactose Enhances Operant Conditioning and Long-Term Potentiation via Gut-Brain Communication through the Vagus Nerve in Rodents

Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents

Fucosylated but Not Sialylated Milk Oligosaccharides Diminish Colon Motor Contractions

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