Enhancement of experimental actinomycosis in mice by Eikenella corrodens

Jordan, H.V.; Kelly, D M; Heeley, J.D.

doi:10.1128/iai.46.2.367-371.1984

Cited by 45 publications

(8 citation statements)

References 6 publications

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“…The observation that very high numbers of Actitwtnyees organisms are needed to form persistent infections (3,17) is corroborated by our attempt to induce experimental infections in this study. But it is unlikely that such high numbers of these bacteria may gain entry into the periapical tissue from an infected root canal.…”

Section: Discussionsupporting

confidence: 74%

Pathogenicity of Actinomyces israelii and Arachnid propionica: experimental infection in guinea pigs and phagocytosis and intracellular killing by human polymorphonuclear leukocytes in vitro

Figdor¹,

Sjögren²,

Sörlin³

et al. 1992

Oral Microbiology and Immunology

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Strains of Actinomyces israelii and Arachnia propionica, isolated from clinical cases of failed endodontic therapy, were examined for: (i) their ability to survive and establish themselves in the soft connective tissue that grew into subcutaneously implanted tissue cages in guinea pigs; (ii) cell-surface hydrophobicity; and (iii) phagocytosis and killing by human polymorphonuclear leukocytes (PMNs) under aerobic and anaerobic conditions. Bacteria were inoculated into the tissue cages in guinea pigs and the cage contents were retrieved after 1, 7, 14 and 21 d for culturing and light and electron microscopy. Both bacterial species showed substantial decline in the number of bacteria by day 7 after the inoculation. Thereafter, the A. israelii strain recovered and, by day 21, had started to increase in number. Light and electron microscopy revealed the formation of typical actinomycotic colonies. A. propionica, on the other hand, continued to decline in number during the entire period of experimental infection and did not form colonies. Both strains were hydrophobic, readily phagocytosed and were efficiently killed by human PMNs under aerobic and anaerobic conditions in vitro. These results suggest that the pathogenicity of A. israelii is due to its ability to establish characteristic cohesive colonies consisting of branching filamentous organisms that are enmeshed in an extracellular matrix. It seems that the organisms existing in such colonies can collectively evade destruction and elimination by host phagocytic cells, whereas in vitro suspensions of the bacteria are easily phagocytosed and efficiently killed by PMNs. With respect to A. propionica, further investigations are necessary to understand its pathogenicity.

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Section: Discussionsupporting

confidence: 74%

Pathogenicity of Actinomyces israelii and Arachnid propionica: experimental infection in guinea pigs and phagocytosis and intracellular killing by human polymorphonuclear leukocytes in vitro

Figdor¹,

Sjögren²,

Sörlin³

et al. 1992

Oral Microbiology and Immunology

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“…The level of Eikenelia corrodens was signifi-cantly higher In progressing sites harboring A. actinomycetemcomilans than non-progressing sites harboring that species and suggests a possible synergism between these organisms (Table 4). A recent publication by Jordan et al (1984) had demonstrated enhancement of experimental actinomycosis in mice by either E. corrodens or A. actinomycelemcomitans. Within the medical literature, both A. actinomycetemcomilans and E. corrodens have been reported as interacting with other organisms to exaggerate an infectious process (Brill et at.…”

Section: Discussionmentioning

confidence: 99%

Clinical immunologic and microbiologic features of active disease sites in juvenile periodontitis

Mandell¹,

Ebersole²,

Socransky³

1987

J Clinic Periodontology

114

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Eight juvenile periodontitis (JP) patients with progressing disease were evaluated for clinical, immunologic, and microbiologic features. Clinically, bleeding on probing, pocket depth, and attachment level were unrelated to progressing disease. Only Actinobacillus actinomycetemcomitans was related to a marked increase in attachment loss when examined on both a site and patient basis. Eikenella corrodens was significantly elevated in progressing sites with A. actinomycetemcomitans as opposed to non-progressing sites harboring A. actinomycetemcomitans. Eikenella corrodens may function synergistically with A. actinomycetemcomitans to enhance disease in JP patients. Darkfield microscopy was of no value in distinguishing disease activity. All patients screened had elevated serum IgG levels to the same serotype of A. actinomycetemcomitans as that isolated from the subgingival flora. Other elevated serum IgG responses were noted to various organisms including F. nucleatum. B. intermedius, B. gracilus, B. gingivalis and E. corrodens.

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“…Jordan et al established experimental actinomycotic infections in mice and the histological evidence showed that polymorphonuclear leukocytes were not able to penetrate and invade the developing central bacterial granule of A. israelii lesions, which resulted in the “unreachable attack” of the leukocytes towards the bacteria inside the granule, while the existence of the inside bacteria would enhance the viability of Actinomyces cells by producing an anaerobic environment. Thus, the companion bacteria would be able to elaborate the toxins and enzymes as well as inhibiting host defenses to facilitate infections [ 46 ].…”

Section: Biological Functions Of Actinomyces Spmentioning

confidence: 99%

Actinomycesand Alimentary Tract Diseases: A Review of Its Biological Functions and Pathology

Li¹,

Liu²,

Yu³

et al. 2018

BioMed Research International

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Actinomyces are nonmotile, filamentous, Gram-positive bacteria that cause actinomycosis in immunodeficiency patients. Although the prognosis of actinomycosis is good, the diagnosis of actinomycosis is quite difficult. Recent studies on actinomycosis have shown that Actinomyces play an important role in various biological and clinical processes, such as the formation of dental plaque and the degradation of organics in the gastrointestinal tract. Here, the distribution of Actinomyces in the digestive tract, and different biological effects of actinomycosis, and its clinical association with inflammatory diseases are discussed. Furthermore, an overview of the most commonly used treatment methods and drugs used to treat Actinomyces infected alimentary canal diseases is presented.

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Enhancement of experimental actinomycosis in mice by Eikenella corrodens

Cited by 45 publications

References 6 publications

Pathogenicity of Actinomyces israelii and Arachnid propionica: experimental infection in guinea pigs and phagocytosis and intracellular killing by human polymorphonuclear leukocytes in vitro

Pathogenicity of Actinomyces israelii and Arachnid propionica: experimental infection in guinea pigs and phagocytosis and intracellular killing by human polymorphonuclear leukocytes in vitro

Clinical immunologic and microbiologic features of active disease sites in juvenile periodontitis

Actinomycesand Alimentary Tract Diseases: A Review of Its Biological Functions and Pathology

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