Enhancement of Cisplatin Efficacy by Gold Nanoparticles or Microwave Hyperthermia? An In Vitro Study on a Melanoma Cell Line

Moradpoor, Raheleh; Aledavood, Seyed Amir; Rajabi, Omid; Chamani, Jamshidkhan; Sazgarnia, Ameneh

doi:10.17795/ijcp-5925

Cited by 5 publications

(4 citation statements)

References 50 publications

(64 reference statements)

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“…CP and AuNPs synergistically induce cytotoxicity in the MM200 cell line by facilitating CP internalization in the presence of GNPs. In addition, microwave exposure further improves the efficacy of CP therapy in the presence of GNPs on MM200 cells [ 201 ].…”

Section: Types Of Nps Used For Combination Therapymentioning

confidence: 99%

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

Gurunathan

Kang

Qasim

et al. 2018

IJMS

256

133

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Cancer represents a group of heterogeneous diseases characterized by uncontrolled growth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a significant role in the development of nanodrugs, nanodevices, drug delivery systems and nanocarriers. Some of the major issues in the treatment of cancer are multidrug resistance (MDR), narrow therapeutic window and undesired side effects of available anticancer drugs and the limitations of anticancer drugs. Several nanosystems being utilized for detection, diagnosis and treatment such as theranostic carriers, liposomes, carbon nanotubes, quantum dots, polymeric micelles, dendrimers and metallic nanoparticles. However, nonbiodegradable nanoparticles causes high tissue accumulation and leads to toxicity. MDR is considered a major impediment to cancer treatment due to metastatic tumors that develop resistance to chemotherapy. MDR contributes to the failure of chemotherapies in various cancers, including breast, ovarian, lung, gastrointestinal and hematological malignancies. Moreover, the therapeutic efficiency of anticancer drugs or nanoparticles (NPs) used alone is less than that of the combination of NPs and anticancer drugs. Combination therapy has long been adopted as the standard first-line treatment of several malignancies to improve the clinical outcome. Combination therapy with anticancer drugs has been shown to generally induce synergistic drug actions and deter the onset of drug resistance. Therefore, this review is designed to report and analyze the recent progress made to address combination therapy using NPs and anticancer drugs. We first provide a comprehensive overview of the angiogenesis and of the different types of NPs currently used in treatments of cancer; those emphasized in this review are liposomes, polymeric NPs, polymeric micelles (PMs), dendrimers, carbon NPs, nanodiamond (ND), fullerenes, carbon nanotubes (CNTs), graphene oxide (GO), GO nanocomposites and metallic NPs used for combination therapy with various anticancer agents. Nanotechnology has provided the convenient tools for combination therapy. However, for clinical translation, we need continued improvements in the field of nanotechnology.

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Section: Types Of Nps Used For Combination Therapymentioning

confidence: 99%

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

Gurunathan

Kang

Qasim

et al. 2018

IJMS

256

133

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show abstract

“…The synergy between gold NPs and MW is frequently cited to treat the gout disease in the so-called metal-assisted and microwave-accelerated decrystallinization [ 99 , 100 ]. For anticancer purposes instead, gold NPs and MWs are frequently employed together to maximize the effects of chemotherapy in a combined therapeutic approach, even if in some case the combined action of NPs and MWs is sufficient to induce cell death [ 101 , 102 ].…”

Section: Microwave Responding Npsmentioning

confidence: 99%

Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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Cancer has nowadays become one of the leading causes of death worldwide. Conventional anticancer approaches are associated with different limitations. Therefore, innovative methodologies are being investigated, and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell death. The idea is to conjugate two different components, i.e., an external physical input and nanoparticles. Both are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest, thus also limiting the negative outcomes for the surrounding tissues. Tuning both the properties of the nanomaterial and the involved triggering stimulus, it is possible furthermore to achieve not only a therapeutic effect, but also a powerful platform for imaging at the same time, obtaining a nano-theranostic application. In the present review, we highlight the role of nanoparticles as therapeutic or theranostic tools, thus excluding the cases where a molecular drug is activated. We thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and nanoparticles. We perform a special focus on mechanical waves responding nanoparticles, in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

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“…In addition, the cell morphology data ( Figure S2 in Supplementary Materials ) suggested greater cytotoxicity with the AuNPs:CDDP combination. The high cytotoxicity of the combination therapy could be mediated by the ability of AuNPs to enhance passive targeting which could improve CDDP delivery to tumours [ 8 , 49 ]. To gain a deeper understanding of the mechanisms of cytotoxicity, the effects of the combination therapy on oxidative stress markers were studied.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Heat Shock Protein Expression in Alveolar Adenocarcinoma Cells through Gold Nanoparticles and Cisplatin Treatment

Ibrahim,

Akere,

Chakraborty

et al. 2024

Pharmaceutics

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Heat-shock proteins (HSPs) are stress-responsive molecules belonging to the family of evolutionary molecular chaperones known to be crucial in many cancer types, including human alveolar adenocarcinoma cells (A549). These proteins are highly overexpressed in cancers to support their ability to accommodate imbalances in cell signalling, DNA alterations, proteins, and energy metabolism associated with oncogenesis. The current study evaluated the effects of gold nanoparticles (AuNPs) combined with cisplatin (CDDP) on molecular chaperone HSPs in A549 cells. It was found that AuNPs:CDDP decreased the percentage of cell viability (38.5%) measured using the modified lactated dehydrogenase (mLDH) and 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assays. AuNPs:CDDP exposure caused a significant (p < 0.05) increase in reactive oxygen species (ROS) generation by 1.81-fold, apoptosis induction, and a decrease in the mitochondrial membrane potential (MMP) compared to AuNPs or CDDP alone. Similarly, exposure to the AuNPs:CDDP combination had pronounced cytotoxic effects on the expression of HSPs and PI3K/AKT/mTOR, as well as apoptosis-related proteins. The results demonstrate that the combination of AuNPs with CDDP might enhance the anticancer efficacy of CDDP.

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Enhancement of Cisplatin Efficacy by Gold Nanoparticles or Microwave Hyperthermia? An In Vitro Study on a Melanoma Cell Line

Cited by 5 publications

References 50 publications

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer

Remotely Activated Nanoparticles for Anticancer Therapy

Modulation of Heat Shock Protein Expression in Alveolar Adenocarcinoma Cells through Gold Nanoparticles and Cisplatin Treatment

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