Enhancement of angiogenesis by bFGF in mandibular bone graft healing in the rabbit

Tibial segmental defect repair: Chondrogenesis and biomechanical strength modulated by basic fibroblast growth factor

“…It has been shown that chondrogenesis and angiogenesis are dose-dependent in in vivo experiments (Cuevas et al, 1988;Presta and Rifkin, 1988;Jingushi et al, 1990Jingushi et al, , 1994Frenkel et al, 1992;Kawaguchi et al, 1994), and withdrawal of bFGF results in the tissue reverting to normal (control) appearances and values (Eppley et al, 1988). Our observation that chondrogenesis was stimulated by bFGF at 2 weeks but not beyond suggests that the amount of factor available to cells progressively diminished.…”

Tibial segmental defect repair: Chondrogenesis and biomechanical strength modulated by basic fibroblast growth factor

“…It has been shown that chondrogenesis and angiogenesis are dose-dependent in in vivo experiments (Cuevas et al, 1988;Presta and Rifkin, 1988;Jingushi et al, 1990Jingushi et al, , 1994Frenkel et al, 1992;Kawaguchi et al, 1994), and withdrawal of bFGF results in the tissue reverting to normal (control) appearances and values (Eppley et al, 1988). Our observation that chondrogenesis was stimulated by bFGF at 2 weeks but not beyond suggests that the amount of factor available to cells progressively diminished.…”

From the Food and Drug Administration

“…These results indicate a clear biological response to 60 Hz magnetic fields of 1 Gauss or greater (Ref. 11).…”

Nkx2.5/Csx Represses Myofibroblast Differentiation

“…bFGF is a heparin-binding mitogenic protein that mediates the formation of new blood vessels (30) and enhances proliferation of a wide variety of cell types under serum-free or serum-reduced conditions (31). bFGF is also known as a repressor of myofibroblast differentiation (13,(31)(32)(33)(34), which would be consistent with its effects on stimulation of Nkx2.5 expression and consequent repression of a-SMA gene expression.…”

Tibial segmental defect repair: Chondrogenesis and biomechanical strength modulated by basic fibroblast growth factor

“…It has been shown that chondrogenesis and angiogenesis are dose-dependent in in vivo experiments (Cuevas et al, 1988;Presta and Rifkin, 1988;Jingushi et al, 1990Jingushi et al, , 1994Frenkel et al, 1992;Kawaguchi et al, 1994), and withdrawal of bFGF results in the tissue reverting to normal (control) appearances and values (Eppley et al, 1988). Our observation that chondrogenesis was stimulated by bFGF at 2 weeks but not beyond suggests that the amount of factor available to cells progressively diminished.…”

From the Food and Drug Administration

“…These results indicate a clear biological response to 60 Hz magnetic fields of 1 Gauss or greater (Ref. 11).…”

Nkx2.5/Csx Represses Myofibroblast Differentiation

“…bFGF is a heparin-binding mitogenic protein that mediates the formation of new blood vessels (30) and enhances proliferation of a wide variety of cell types under serum-free or serum-reduced conditions (31). bFGF is also known as a repressor of myofibroblast differentiation (13,(31)(32)(33)(34), which would be consistent with its effects on stimulation of Nkx2.5 expression and consequent repression of a-SMA gene expression.…”

Tibial segmental defect repair: Chondrogenesis and biomechanical strength modulated by basic fibroblast growth factor

“…It has been shown that chondrogenesis and angiogenesis are dose-dependent in in vivo experiments (Cuevas et al, 1988;Presta and Rifkin, 1988;Jingushi et al, 1990Jingushi et al, , 1994Frenkel et al, 1992;Kawaguchi et al, 1994), and withdrawal of bFGF results in the tissue reverting to normal (control) appearances and values (Eppley et al, 1988). Our observation that chondrogenesis was stimulated by bFGF at 2 weeks but not beyond suggests that the amount of factor available to cells progressively diminished.…”

From the Food and Drug Administration

“…These results indicate a clear biological response to 60 Hz magnetic fields of 1 Gauss or greater (Ref. 11).…”

Nkx2.5/Csx Represses Myofibroblast Differentiation

“…bFGF is a heparin-binding mitogenic protein that mediates the formation of new blood vessels (30) and enhances proliferation of a wide variety of cell types under serum-free or serum-reduced conditions (31). bFGF is also known as a repressor of myofibroblast differentiation (13,(31)(32)(33)(34), which would be consistent with its effects on stimulation of Nkx2.5 expression and consequent repression of a-SMA gene expression.…”