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Cited by 121 publications
(83 citation statements)
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“…Especially patients suffering from chronic diseases with increased neopterin formation and tryptophan degradation (= elevated kyn/trp), e.g. patients with malignancy, infec-[ions or autoimmune diseases like systemic lupus erythematosus (12,(28)(29)(30), might benefit most from wine or grape juice because of the down-reguiatory effect on activated macrophages.…”
Section: Discussionmentioning
confidence: 99%
“…Especially patients suffering from chronic diseases with increased neopterin formation and tryptophan degradation (= elevated kyn/trp), e.g. patients with malignancy, infec-[ions or autoimmune diseases like systemic lupus erythematosus (12,(28)(29)(30), might benefit most from wine or grape juice because of the down-reguiatory effect on activated macrophages.…”
Section: Discussionmentioning
confidence: 99%
“…26 An increased K/T quotient indicates an increased catabolism, of tryptophan probably through IFN␣-induced IDO. 7 IFN␥ and IFN␣ may induce IDO in the brain, kidney, lung, spleen, duodenum and immune cells. 24,27 Our findings extend previous results showing that inflammatory conditions and disorders are accompanied by lower serum DPP IV activity [14][15][16]28 and that in depression lowered serum DPP IV is related to signs of IRS activation.…”
Section: −4mentioning
confidence: 99%
“…Whereas the tolerogenic outcome of a low-Trp level may be bad for the host in infections, it is believed that in autoimmunity, Trp degradation may help to balance peripheral tolerance (4). In vivo, lower Trp levels were measured systemically in circumstances connected to chronic inflammation such as in viral diseases including HIV infection, but also in chronic autoimmune disorders such as lupus erythematosus (27)(28)(29)(30). Our group recently established that in lichen planus, an autoimmune skin disease of unknown etiology, myeloid DCs do express high IDO activity.…”
mentioning
confidence: 99%
“…In NOD mice, it was found that an impaired Trp catabolism is causative to the defective tolerance (32). In systemic lupus erythematosus and in viral infections, there is a lot of local and systemic IDO activity (29,33). In these chronic infections, the induction of tolerogenic DCs by low Trp may add to the observed immunosuppression seen in these patients.…”
mentioning
confidence: 99%