Enhanced serum interferon-lambda 1/interleukin-29 levels in patients with psoriasis vulgaris

Fu, Lianshe; Chen, Tao; Guo, Zhanfang; Cao, Na; Zhang, Liwen; Zhou, Peimei

doi:10.1016/j.abd.2020.11.007

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…Other members of the miR-548 family down-regulate host antiviral response via direct targeting interferon-λ1 (IFN-λ1). For example, inhibition of miR-548b-5p, miR-548c-5p, miR-548i, and miR-548j increased IFN-λ1 secretion, and the targeted IFN-λ1 gene can induce IP-10, MCP1, IL-8 ( Fu et al., 2021 ). The chemokine MCP-1 was seen affected by miR548d-3p in the present study.…”

Section: Discussionmentioning

confidence: 99%

miR-548d-3p Is Up-Regulated in Human Visceral Leishmaniasis and Suppresses Parasite Growth in Macrophages

Ramos-Sanchez

Reis

Souza

et al. 2022

Front. Cell. Infect. Microbiol.

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Visceral leishmaniasis caused by Leishmania (Leishmania) infantum in Latin America progress with hepatosplenomegaly, pancytopenia, hypergammaglobulinemia, and weight loss and maybe lethal mainly in untreated cases. miRNAs are important regulators of immune and inflammatory gene expression, but their mechanisms of action and their relationship to pathogenesis in leishmaniasis are not well understood. In the present study, we sought to quantify changes in miRNAs associated with immune and inflammatory pathways using the L. (L.) infantum promastigote infected- human monocytic THP-1 cell model and plasma from patients with visceral leishmaniasis. We identified differentially expressed miRNAs in infected THP-1 cells compared with non-infected cells using qPCR arrays. These miRNAs were submitted to in silico analysis, revealing targets within functional pathways associated with TGF-β, chemokines, glucose metabolism, inflammation, apoptosis, and cell signaling. In parallel, we identified differentially expressed miRNAs in active visceral leishmaniasis patient plasma compared with endemic healthy controls. In silico analysis of these data indicated different predicted targets within the TGF-β, TLR4, IGF-I, chemokine, and HIF1α pathways. Only a small number of miRNAs were commonly identified in these two datasets, notably with miR-548d-3p being up-regulated in both conditions. To evaluate the potential biological role of miR-548d-3p, we transiently transfected a miR-548d-3p inhibitor into L. (L.) infantum infected-THP-1 cells, finding that inhibition of miR-548d-3p enhanced parasite growth, likely mediated through reduced levels of MCP-1/CCL2 and nitric oxide production. Further work will be required to determine how miR-548d-3p plays a role in vivo and whether it serves as a potential biomarker of progressive leishmaniasis.

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Section: Discussionmentioning

confidence: 99%

miR-548d-3p Is Up-Regulated in Human Visceral Leishmaniasis and Suppresses Parasite Growth in Macrophages

Ramos-Sanchez

Reis

Souza

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Previous studies showed that cytokines including IL-4, TNF- α , and IL-1 β -were enhanced in serum of AD patients [ 33 ]. Higher level of IFN- γ and IL-6 was detected in skin lesions of AD patients [ 34 ]. In our study, the levels of IL-4, TNF- α , INF- γ , and IgE in serum were reduced; meanwhile, the inflammation of back skin, the skin inflammation score, and the ear swelling of mice were alleviated after taking the TXS.…”

Section: Discussionmentioning

confidence: 99%

Ta-Xi-San Suppresses Atopic Dermatitis Involved in Multitarget Mechanism Using Experimental and Network Pharmacology Analysis

Zhi

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Atopic dermatitis (AD) is a relapsing and chronic skin inflammation with a common incidence worldwide. Ta-Xi-San (TXS) is a Chinese herbal formula usually used for atopic dermatitis in clinic; however, its active compounds and mechanisms of action are still unclear. Our study was designed to reveal the pharmacological activities, the active compounds, and the pharmacological mechanisms of TXS for atopic dermatitis. Mice were induced by 2,4-dinitrocluorobenzene (DNCB) to build atopic dermatitis model. The pathological evaluation, enzyme-linked immunosorbent assay (ELISA), and hematoxylin and eosin (H&E) assay were performed. The UPLC-Q-Exactive-MSE and network pharmacology analysis were performed to explore active ingredients and therapeutic mechanisms of TXS. TXS treatment decreased levels of immunoglobulin E (IgE), interleukin-4 (IL-4), and tumor necrosis factor-α (TNF-α) in serum induced by DNCB. TXS reduced scratching behavior and alleviated inflammatory pathology of skin and ear. Meanwhile, TXS decreased the spleen index and increased spleen index. The UPLC-Q-Exactive-MSE results showed that 65 compounds of TXS were detected and 337 targets were fished. We collected 1371 AD disease targets, and the compound-target gene network reveled that the top 3 active ingredients were (−)-epigallocatechin gallate, apigenin, and esculetin, and the core target genes were PTGS2, PTGS1, and HSP90AA1. The KEGG pathway and GO analysis showed that TXS remedied atopic dermatitis via PI3K-Akt signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway, and Toll-like receptor (TLR) signaling pathway with the regulation of inflammatory response and transcription. Further, we found that the targets of PTGS2 and HSP90AA1 were both elevated in ears and skin of AD model mouse; however, TXS decreased the elevated expressions of PTGS2 and HSP90AA1. Our study revealed that TXS ameliorated AD based on (−)-epigallocatechin gallate, apigenin, and esculetin via targeting PTGS2 and HSP90AA1.

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The role and application of three IFN-related reactions in psoriasis

He,

Zhao,

et al. 2023

Biomedicine & Pharmacotherapy

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Enhanced serum interferon-lambda 1/interleukin-29 levels in patients with psoriasis vulgaris

Cited by 6 publications

References 21 publications

miR-548d-3p Is Up-Regulated in Human Visceral Leishmaniasis and Suppresses Parasite Growth in Macrophages

miR-548d-3p Is Up-Regulated in Human Visceral Leishmaniasis and Suppresses Parasite Growth in Macrophages

Ta-Xi-San Suppresses Atopic Dermatitis Involved in Multitarget Mechanism Using Experimental and Network Pharmacology Analysis

The role and application of three IFN-related reactions in psoriasis

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