1997
DOI: 10.1080/109158197226937 View full text |Buy / Rent full text
|
|

Abstract: C h ih -M i n K a m a n d J oe S elz ler S ch ool of C h e m is t r y a n d B ioch e m is t r y, G eor gia I n s t it u t e of Te ch n olog y, At la n t a , G e or gia , U S A S u sa n M . S ch u lz a n d R u d olf o B on g iov a n n i D r u g As s e s s m e n t D ivis ion , U .S . Ar m y R e s ea r ch I n s t it u t e of C h e m ica l D e fe n s e , Ab e r d e e n P r ov in g G r ou n d , M a r yla n d , U S A J a m es C . P ow ers S ch ool of C h e m is t r y a n d B ioch e m is t r y, G eor gia I n s t it u… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
3
1
1
0
5
0

Year Published

2001
2001
2015
2015

Publication Types

Select...
3
1

Relationship

1
3

Authors

Journals

0
5
0
Order By: Relevance
“…[2][3][4] The HD-exposed skin homogenate samples showed enhanced elastase and tryptase activities, whereas the chymase and Asp-ase activities in these samples were not increased. 3 In the mouse ear vesicant model, evaluation of the endpoint responses (e.g. edema, histopathological responses) at various HD doses and time points indicated that a dose of 0.16 mg of HD per ear at 24 h post-exposure would be an optimal condition for future testing.…”
Section: Protease Activitiesmentioning
See 1 more Smart Citation
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…[2][3][4] The HD-exposed skin homogenate samples showed enhanced elastase and tryptase activities, whereas the chymase and Asp-ase activities in these samples were not increased. 3 In the mouse ear vesicant model, evaluation of the endpoint responses (e.g. edema, histopathological responses) at various HD doses and time points indicated that a dose of 0.16 mg of HD per ear at 24 h post-exposure would be an optimal condition for future testing.…”
Section: Protease Activitiesmentioning
“…3,4 The protease activities are inhibited by several protease inhibitors. 3,5 These results indicated that proteases may play a role in HD-induced inflammation and vesication.…”
Section: Introductionmentioning
“…These modifications can result in the release of proteases, which attack and degrade major structural proteins including collagen and proteoglycans. Activation of proteolytic enzymes has been linked to the vesication following SM exposure (Kam et al ., ; Powers et al ., ). Activation of proteases can also initiate and promote inflammation, a well‐characterized response to SM‐induced vesication (Cowan et al ., ; Rikimaru et al ., ).…”
Section: Introductionmentioning
“…Biomarkers that have been associated with HD-induced skin toxicity include altered cellular metabolism and viability, protease activation, increased skin myeloperoxidase (MPX) activity and elevated levels of proinflammatory cytokines. [4][5][6][7][8] The intent of this study was to establish a procedure for tissue preparation in which multiple biomarker measurements, including MPX, could be made. Tissue homogenates require hexadecyltrimethylammonium bromide (HTAB) treatment for MPX solubilization and measurement, 9 but HTAB is not required in measuring soluble inflammatory mediators.…”
Section: Introductionmentioning