Enhanced Sensitivity of Cancer Stem Cells to Chemotherapy Using Functionalized Mesoporous Silica Nanoparticles

Chen, Zhenzhen; Zhu, Pingping; Zhang, Yushun; Liu, Yating; Zhang, Lifen; Gao, Yanfeng

doi:10.1021/acs.molpharmaceut.6b00352

Cited by 34 publications

(23 citation statements)

References 33 publications

(73 reference statements)

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“…Cancer stem cells (CSCs) have been defined to be a small subset of cancer cells within the tumour bulk, exhibiting self-renewal and differentiation capacities3. CSCs may well contribute to tumour initiation, metastasis, recurrence, as well as drug resistance345. Liver CSCs can be enriched by some defined surface markers678.…”

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confidence: 99%

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

et al. 2016

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Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs remains largely undefined. Through analysis of transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM, which is highly expressed in liver CSCs and HCC tumours. LncBRM is required for the self-renewal maintenance of liver CSCs and tumour initiation. In liver CSCs, lncBRM associates with BRM to initiate the BRG1/BRM switch and the BRG1-embedded BAF complex triggers activation of YAP1 signalling. Moreover, expression levels of lncBRM together with YAP1 signalling targets are positively correlated with tumour severity of HCC patients. Therefore, lncBRM and YAP1 signalling may serve as biomarkers for diagnosis and potential drug targets for HCC.

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confidence: 99%

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

et al. 2016

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“…Gastric TICs are also optimal targets for gastric tumor targeting(SR Singh 2013). However, TICs are resistant to traditional drugs, with high expression of pump molecules like ABCG2(ZZ Chen et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circGTIC1 drives gastric TIC self-renewal to initiate gastric tumorigenesis and metastasis

Wang

Xiao

et al. 2019

Preprint

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Gastric cancer is one of the most serious cancers all over the world. Gastric tumor initiating cells (TIC) account for gastric tumorigenesis and metastasis. Here we identified circGTIC1 as a highly expressed circRNA in gastric cancer and gastric TICs. circGTIC1 knockout inhibited the self-renewal of gastric TICs and metastasis, and its overexpression activated gastric TICs. circGTIC1 drove the expression of Sox8 and exerted its role via Sox8-dependent manner. circGTIC1 associated with Ino80 chromatin remodeling complex, and recruited Ino80 complex to Sox8 promoter, finally initiated Sox8 expression. Our work revealed a novel circRNA to regulate gastric tumorigenesis and gastric TICs, adding a new layer for gastric TIC regulation and circRNA functions. CircGTIC1 plays a central role in gastric TIC self-renewal and metastasis. circGTIC1 drives the expression of Sox8 through recruiting Ino80 complex to Sox8 promoter. circGTIC1-Ino80-Sox8 axis can be used for gastric tumor and gastric TIC targeting. Our work revealed a novel circRNA to regulate gastric tumorigenesis and gastric TICs, adding a new layer for gastric TIC regulation and circRNA functions

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“…Durfee et al showed that MSNs-supported lipid bilayers (protocells) were capable of active targeting and delivery to individual leukemia cells (Durfee et al, 2016). Chen et al employed functionalized MSNs to enhance sensitivity of cancer stem cells to chemotherapy (Chen et al, 2016). Datz et al demonstrated that genetically designed biomolecular capping system for MSNs enabled receptor-mediated cell uptake and controlled drug release (Datz et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Mesoporous Silica Nanoparticles Rescue H<sub>2</sub>O<sub>2</sub>-induced Inhibition of Cardiac Differentiation

Ren

Wang

Huang

et al. 2018

Cell Struct. Funct.

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The anti-oxidative property of mesoporous silica nanoparticles (MSNs) has been proposed previously, which prompted us to investigate the potential protective effect of MSNs on human embryonic stem cells (hESCs) against oxidative stress. To this purpose, the cell viability was determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. Apoptosis was analyzed by Annexin V/propidium iodide double-staining method. The intracellular glutathione, superoxide dismutase and malondialdehyde were measured with commercial assay kits. The reactive oxygen species was detected by staining with fluorescent dye DCFH-DA. The relative levels of Nkx2.5, Mef2c, Tbx5, dHand and α-MHC transcripts were measured by real-time polymerase chain reaction. The protein levels of Connexin 43, Troponin C1 and GAPDH were determined by immunoblotting. The beating behavior of embryoid bodies (EBs) was visually examined. Our results demonstrated that MSNs reversed hydrogen peroxide (HO)-inhibited cell viability and ameliorated HO-induced cell apoptosis in vitro. The HO-elicited intracellular oxidative stress was significantly relieved in the presence of MSNs. Furthermore, MSNs improved HO-suppressed differentiation of hESC-derived EBs and the maturation of the cardiomyocytes. In addition, MSNs treatment enhanced the beating properties of EBs. MSNs effectively conferred protection on hESCs against oxidative stress with respect to cardiac differentiation.Key words: Mesoporous silica nanoparticles, hydrogen peroxide, human embryonic stem cells, differentiation.

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Enhanced Sensitivity of Cancer Stem Cells to Chemotherapy Using Functionalized Mesoporous Silica Nanoparticles

Cited by 34 publications

References 33 publications

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

Circular RNA circGTIC1 drives gastric TIC self-renewal to initiate gastric tumorigenesis and metastasis

Mesoporous Silica Nanoparticles Rescue H<sub>2</sub>O<sub>2</sub>-induced Inhibition of Cardiac Differentiation

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