Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan

Yabuuchi, Shun; Oiki, Shigetoshi; Minami, Shuma; Takase, Ryuichi; Watanabe, Dai; Hashimoto, Wataru

doi:10.1038/s41598-022-14857-9

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Our epidemiologic study was designed to provide a cross-sectional description of the abundances of different oral bacterial taxa in the mouth and was not designed to identify pathways by which they influence HIV pathogenesis. Nevertheless, two of the oral taxa, Streptococcus and Granulicatella , which we found to be more abundant in CWH, are known to degrade Hyaluronan (hyaluronic acid) an enzyme, which may help reduce the virulence of infections [41]. Abundance of Granulicatella in the mouth has also been linked to salivary levels of the proinflammatory cytokine IL-8 [42].…”

Section: Discussionmentioning

confidence: 80%

Microbiota in the oral cavity of school-age children living with HIV who started antiretroviral therapy at young ages in South Africa

Kuhn

Fan

Strehlau

et al. 2023

Aids

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Background: Infancy is an important developmental period when the microbiome is shaped. We hypothesized that earlier antiretroviral therapy (ART) initiation would attenuate HIV effects on microbiota in the mouth. Methods: Oral swabs were collected from 477 children with HIV (CWH) and 123 children without (controls) at two sites in Johannesburg, South Africa. CWH had started ART less than 3 years of age; 63% less than 6 months of age. Most were well controlled on ART at median age 11 years when the swab was collected. Controls were age-matched and recruited from the same communities. Sequencing of V4 amplicon of 16S rRNA was done. Differences in microbial diversity and relative abundances of taxa were compared between the groups. Results: CWH had lower alpha diversity than controls. Genus-level abundances of Granulicatella, Streptococcus, and Gemella were greater and Neisseria and Haemophilus less abundant among CWH than controls. Associations were stronger among boys. Associations were not attenuated with earlier ART initiation. Shifts in genus-level taxa abundances in CWH relative to controls were most marked in children on lopinavir/ritonavir regimens, with fewer shifts seen if on efavirenz ART regimens. Conclusion: A distinct profile of less diverse oral bacterial taxa was observed in school-aged CWH on ART compared with uninfected controls suggesting modulation of microbiota in the mouth by HIV and/or its treatments. Earlier ART initiation was not associated with microbiota profile. Proximal factors, including current ART regimen, were associated with contemporaneous profile of oral microbiota and may have masked associations with distal factors such as age at ART initiation.

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Section: Discussionmentioning

confidence: 80%

Microbiota in the oral cavity of school-age children living with HIV who started antiretroviral therapy at young ages in South Africa

Kuhn

Fan

Strehlau

et al. 2023

Aids

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“…suggested that saliva glycosaminoglycans contribute to the formation and composition of the oral microbiota, influencing not only colonization but also adaptation to the host niche. Hyaluronan, for instance, has been found to enhance the proliferation of Granulicatella adiacens (Yabuuchi et al., 2022). Saliva includes various buffering systems, including those based on phosphate and bicarbonate, to maintain the intraoral pH around neutrality, thus providing a stable environment for oral bacteria (Wade, 2021).…”

Section: The Roles Of Three Components In the Oral–microbiota–brain Axismentioning

confidence: 99%

The coming future: The role of the oral–microbiota–brain axis in aroma release and perception

Xi,

Yu,

et al. 2024

Comp Rev Food Sci Food Safe

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The field of aroma release and perception during the oral process has been well studied. However, the traditional approaches have not fully explored the integration of oral biology, microbiology, and neurology to further understand aroma release and perception mechanisms. Herein, to address the existing challenges in this field, we introduce the oral–microbiota–brain axis (OMBA), an innovative framework that encapsulates the interactive relationships among saliva and the oral mucosa, the oral microbiota, and the brain in aroma release and perception. This review introduces the OMBA and highlights its role as a key interface facilitating the sensory experience of aroma. Based on a comprehensive literature survey, the specific roles of the oral mucosa, oral microbiota, saliva, and brain in the OMBA are discussed. This integrated approach reveals the importance of each component and the interconnected relationships within this axis in the overall process of aroma release and perception. Saliva and the oral mucosa play fundamental roles in aroma release and perception; the oral microbiota regulates aroma release and impacts olfactory perception; and the brain's intricate neural circuitry is central to the decoding and interpretation of aroma signals. The components of this axis are interdependent, and imbalances can disrupt aroma perception. The OMBA framework not only enhances our comprehension of aroma release and perception but also paves the way for innovative applications that could heighten sensory experiences.

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Dominance of Prevotella Species in Tobacco Consumers: A Metagenomic Preliminary Study

Savalia,

Patel,

Singh

et al. 2024

Biosci., Biotech. Res. Asia

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The human mouth cavity provides valuable clinical information about both oral and overall well-being. Tobacco has an impact on the oral microbiome, which is connected to a range of systemic disorders. Global studies are examining tobacco usage and other factors, including bacteria's role in oral cancer. Although there have been studies examining the connection between tobacco and the oral microbiota using 16S rRNA amplicon sequencing, there is a lack of investigations application of metagenomic sequences. we investigate, a total of 64 samples were obtained from each of the three categories: Tobacco chewers, Tobacco smokers and Normal healthy individuals. The samples were processed in duplicates. Total 10gbp data was generated with more than 90% good quality sequences and were used in downstream analysis. Metagenomic analysis was carried out using QIIME 2-2022.2 using the default parameters. An investigation was conducted to compare the prevalence of 18 species of Prevotella, which are found in high abundance in tobacco chewers (0.004%) as well as tobacco smokers (0.0017%) with compare to normal healthy persons (0.0008%). Total 15 species are absent in healthy individuals but present in tobacco consumers, while 30 species are found to be highly prevalent in tobacco chewers 12 species are highly abundant in tobacco smokers. Streptococcus was the most prevalent genus found among all the samples.

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Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan

Cited by 3 publications

References 46 publications

Microbiota in the oral cavity of school-age children living with HIV who started antiretroviral therapy at young ages in South Africa

Microbiota in the oral cavity of school-age children living with HIV who started antiretroviral therapy at young ages in South Africa

The coming future: The role of the oral–microbiota–brain axis in aroma release and perception

Dominance of Prevotella Species in Tobacco Consumers: A Metagenomic Preliminary Study

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