Enhanced luminol–O<sub>2</sub> chemiluminescence reaction by CuO nanoparticles as oxidase mimics and its application for determination of ceftazidime

Iranifam, Mortaza; Imani-Nabiyyi, Amin; Khataee, Alireza; Kalantari, Jalil

doi:10.1039/c6ay00309e

Cited by 23 publications

(10 citation statements)

References 47 publications

(60 reference statements)

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“…The change of electrons from the excited state to the ground state releases energy, causing light emission at 425 nm. Although CL is a flash phenomenon in the millisecond time scale,[6b,16] the use of thin Au nanoplates and TCEP continuously supplies oxygen singlet to the CL reaction, enabling a stable long‐term emission. This is of importance to monitor chemical reactions or use detection systems that require sufficient reaction or processing time.…”

Section: Resultsmentioning

confidence: 99%

Gold Nanoplate‐Enhanced Chemiluminescence and Macromolecular Shielding for Rapid Microbial Diagnostics

Bui

Brockgreitens

Abbas

2018

Adv Healthcare Materials

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With the global rise of antimicrobial resistance, rapid screening and identification of low concentrations of microorganisms in less than 1 h becomes an urgent technological need for evidence-based antibiotic therapy. Although many commercially available techniques are labeled for rapid microbial detection, they often require 24-48 h of cell enrichment to reach detectable levels. Here, it is shown that the widely used reducing agent tris(2-carboxyethyl)phosphine (TCEP) can also act as a powerful oxidant on gold nanoplates and subsequently lead to a strong catalysis of luminol chemiluminescence. The catalytic reaction results in up to 100-fold signal enhancement and unprecedented stable luminescence for up to 10 min. However, when TCEP is exposed to microorganisms, it is oxidized by the microbial surface proteins and loses its catalytic properties, leading to a decrease in chemiluminescence. The competitive interaction of TCEP with Au nanoplates and microorganisms is used to introduce a homogenous rapid detection method that allows microbial screening in less than 10 min with a limit of detection down to 100 cfu mL . Furthermore, the concept of microbial macromolecular shielding using antibody-conjugated polymers is introduced. The combination of TCEP redox activity and macromolecular shielding enables specific microbial identification within 1 h, without preconcentration, cell enrichment, or heavy equipment other than a hand-held luminometer. The technique is demonstrated by specific detection of methicillin-resistant Staphylococcus aureus in environmental and urine samples containing a mixture of microorganisms.

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Section: Resultsmentioning

confidence: 99%

Gold Nanoplate‐Enhanced Chemiluminescence and Macromolecular Shielding for Rapid Microbial Diagnostics

Bui

Brockgreitens

Abbas

2018

Adv Healthcare Materials

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“… 2 It is also used in the empirical therapy of febrile neutropenia in combination with other antibiotics. 3 The analysis of ceftazidime is performed by HPLC, 4 UV/Vis, 5 GC/MS, 6–9 LC/MS, 10,11 IR, 12 LC/MS/MS, 13 capillary electrophoresis, 14–16 and chemiluminescence 17 in biological samples. Recently, magnetic nanoparticles (MNPs) have been widely used as drug carriers due to their size, shape, and magnetic field.…”

Section: Introductionmentioning

confidence: 99%

The synthesis, characterization and applications of poly[N-isopropylacrylamide-co-3-allyloxy-1,2-propanediol] grafted onto modified magnetic nanoparticles

2020

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“…The chemiluminescence (CL) has been accepted as a powerful analytical tool especially for the trace determination of inorganic and organic species in chemical, environmental, food, and biological fields . It is a light emission phenomenon that occurs in chemical reactions .…”

Section: Introductionmentioning

confidence: 99%

Pt NPs catalyzed chemiluminescence method for Hg²⁺ detection based on a flow injection system

Zheng

Zhao

et al. 2019

Electrophoresis

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Establishing a simple and accurate method for Hg2+ detection is of great importance for the environment and human health. In this work, platinum nanoparticles (Pt NPs) with different capped agents and morphologies were synthesized. It was found that Pt NPs exhibited peroxidase‐like activity that can catalyze the chemiluminescence (CL) of the luminol system without H2O2. The most intensive CL signals were obtained by using PVP‐capped Pt NPs as catalysis. Based on the fact that Hg2+ could further enhance the CL intensity in the Pt NPs‐luminol CL system, a Pt NPs‐catalyzed CL method based on a flow injection system is developed for the sensitive analysis of Hg2+. When the concentration of Hg2+ in the system increases, the CL intensity would together increase, thereby achieving sensitive Hg2+ detection. The limit of detection (LOD) was calculated to be 8.6 nM. This developed method provides a simple and rapid approach for the sensitive detection of Hg2+ and shows great promise for applications in other complex systems.

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Enhanced luminol–O₂ chemiluminescence reaction by CuO nanoparticles as oxidase mimics and its application for determination of ceftazidime

Abstract: A cursory survey of the literature shows that although peroxidase-like activity is a well-known and well-applied property of CuO nanoparticles (CuO NPs), the oxidase-like activity of CuO NPs is a property that is somehow neglected to be incorporated in analytical applications.

Cited by 23 publications

References 47 publications

Gold Nanoplate‐Enhanced Chemiluminescence and Macromolecular Shielding for Rapid Microbial Diagnostics

Gold Nanoplate‐Enhanced Chemiluminescence and Macromolecular Shielding for Rapid Microbial Diagnostics

The synthesis, characterization and applications of poly[N-isopropylacrylamide-co-3-allyloxy-1,2-propanediol] grafted onto modified magnetic nanoparticles

Pt NPs catalyzed chemiluminescence method for Hg²⁺ detection based on a flow injection system

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Enhanced luminol–O2 chemiluminescence reaction by CuO nanoparticles as oxidase mimics and its application for determination of ceftazidime

Abstract: A cursory survey of the literature shows that although peroxidase-like activity is a well-known and well-applied property of CuO nanoparticles (CuO NPs), the oxidase-like activity of CuO NPs is a property that is somehow neglected to be incorporated in analytical applications.

Cited by 23 publications

References 47 publications

Gold Nanoplate‐Enhanced Chemiluminescence and Macromolecular Shielding for Rapid Microbial Diagnostics

Gold Nanoplate‐Enhanced Chemiluminescence and Macromolecular Shielding for Rapid Microbial Diagnostics

The synthesis, characterization and applications of poly[N-isopropylacrylamide-co-3-allyloxy-1,2-propanediol] grafted onto modified magnetic nanoparticles

Pt NPs catalyzed chemiluminescence method for Hg2+ detection based on a flow injection system

Contact Info

Product

Resources

About

Enhanced luminol–O₂ chemiluminescence reaction by CuO nanoparticles as oxidase mimics and its application for determination of ceftazidime

Pt NPs catalyzed chemiluminescence method for Hg²⁺ detection based on a flow injection system