Enhanced Liposomal Encapsulation of Ascorbic Acid by the Liquid Crystal β-sitosteryl-β-D-glucopyranoside

Dissanayake, Deepamali; Karunaratne, D. Nedra; Perera, A. D. L. Chandani

doi:10.1080/15421406.2015.1047297

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Interestingly, the three β-sitosterol sugar esters showed general lyotropic liquid crystal properties like birefringence, suggesting that they had excellent hydrogen-bonding networks and the ability to arrange themselves in spherical or non-spherical micelles. Among them, the texture of β-sitosterol sucrose adipate was very clear; it was similar to that of β-sitosteryl-β- d -glucopyranoside as seen in optical polarizing micrographs of the latter in water . However, the textures of β-sitosterol glucose adipate and β-sitosterol raffinose adipate were weakened to some extent; this weakening was presumably caused by the dissolution rate and water solubility.…”

Section: Resultsmentioning

confidence: 74%

“…Among them, the texture of β-sitosterol sucrose adipate was very clear; it was similar to that of β-sitosteryl-β-D-glucopyranoside as seen in optical polarizing micrographs of the latter in water. 39 However, the textures of β-sitosterol glucose adipate and β-sitosterol raffinose adipate were weakened to some extent; this weakening was presumably caused by the dissolution rate and water solubility.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Synthesis, Physical Properties, and In Vitro-Simulated Gastrointestinal Digestion of Hydrophilic β-Sitosterol Sugar Esters

Liu

et al. 2022

J. Agric. Food Chem.

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Hydrophilic β-sitosterol sugar esters were synthesized by a two-step biocatalytic approach using β-sitosterol vinyl adipate as an intermediate. The maximum conversion (above 90%) of β-sitosterol vinyl adipate was achieved using the saccharides glucose, sucrose, and raffinose. The chemical structure of the synthesized esters was confirmed by various techniques. The investigation of physical properties revealed that β-sitosterol sugar esters had enhanced water solubility (3.0–8.0 mM at 35 °C), reduced crystallinity, and high wettability. Their lyotropic liquid crystal properties were observed by polarized light microscopy. Furthermore, β-sitosterol sugar esters could be hydrolyzed into β-sitosterol adipate under simulated intestinal conditions at a low rate (2.83–18.14%). Most β-sitosterol sugar esters probably entered into intestinal bile salt micelles with ester bonds intact and showed up to 10-fold higher in vitro bioaccessibility than free β-sitosterol in non-fat systems. The excellent physical and functional characteristics of β-sitosterol sugar esters suggested their great potential application in the food industry.

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Section: Resultsmentioning

confidence: 74%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Synthesis, Physical Properties, and In Vitro-Simulated Gastrointestinal Digestion of Hydrophilic β-Sitosterol Sugar Esters

Liu

et al. 2022

J. Agric. Food Chem.

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“…However, there is a great potential with the limited number of scientists who are actively associated with research in nano-drug carriers, antibacterial agents, and bone prostheses. These include development of bone prostheses (Rajapakse et al, 2016), drug encapsulation, for example, Vitamin C (Samantha Dissanayake et al, 2015), targeted cancer treatment (Katuwavila et al, 2016a;Weerasuriya et al, 2017;Nwokwu et al, 2017;Manatunga et al, 2017;Manatunga et al, 2018a), and developing antimicrobial agents (Peiris et al, 2017;Rathnayake et al, 2018). Rajapakse et al have actively engaged in nano hydroxyapatite-based biomaterials ( Fig.…”

Section: State Of Nanomedicine Research In Sri Lankamentioning

confidence: 99%

“…Many Sri Lankan scientists have reported a sizable amount of work related to anticancer drug delivery systems. Most of these drug delivery systems are based on chitosan alginate nanoparticles (Katuwavila et al, 2016a;Katuwavila et al, 2016b) or liposomes (Samantha Dissanayake et al, 2015;Pamunuwa et al, 2016;Pamunuwa et al, 2015;Menikarachchi et al, 2016;Nwokwu et al, 2017). They have been tested on various cancer cell lines such as breast (Katuwavila et al, 2016a) and lung (Nwokwu et al, 2017) cancer.…”

Section: State Of Nanomedicine Research In Sri Lankamentioning

confidence: 99%

The state of nanomedicine in Sri Lanka: challenges and opportunities

Manatunga

Silva

2018

J of Interdiscip Nanomed

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Nanomedicine is rapidly expanding in the world due to its potential impact in alleviating various critical problems related to health. In this short review, we highlight the developments in nanomedicine in Sri Lanka through the work carried out by various scientists within the country. Potential challenges in the field and obstacles for conversion to clinical products will also be discussed. Even though there are limited contributions in relation to nano-drug carriers, antibacterial agents, and bone prostheses, the research focused on vaccine development, diagnosis, and imaging tools, and high-throughput screening platforms have not been developed. The main emphasis has been on therapeutic applications and anticancer drug delivery. Many hybrid biocompatible materials have been developed for drug delivery applications; however, work has been limited to in vitro studies due to various reasons. These findings can be extended to in vivo studies by strengthening the collaboration between nanotechnologists and health-related scientists, whose contribution at the clinical stages is paramount. Because of the slow pace of infrastructure development and related policies for clinical trials, many discoveries are terminated at the publication stage. Therefore, product development and commercialization are very challenging in the Sri Lankan context. The attraction of venture capitalists, investors, and government commitment represent current challenges for the product development and implementation of nanomedicine applications within the country.

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“…Indeed, the sharp rise and rapid development of mild sugar-based surfactants such as AGs and APGs have been highly accepted. − Nevertheless, APGs and/or AGs have weak hydrophilicity and poor water solubility , compared to other surfactants such as cationic surfactants, anionic surfactants, and other nonionic surfactants. Thus, their commercial application and scientific research are somewhat restricted.…”

Section: Introductionmentioning

confidence: 99%

Water Solubility and Surface Activity of Alkoxyethyl β-d-Maltosides

Fan

Chen

et al. 2020

J. Agric. Food Chem.

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Green surfactants alkyl glycosides are key to solve the inherent problem of water solubility due to their commercial application and extensive scientific research. Based on the enhancement strategy of hydrophilicity through the reconstruction of the conventional alkyl β-D-maltoside by introducing an oxyethyl group (−OCH 2 CH 2 −), D-maltose was used to prepare a series of nonionic disaccharide-based surfactants alkoxyethyl β-D-maltosides (4a−h, n = 6−16) so that the related water solubility was effectively improved, while the corresponding surface activity and other excellent properties were still maintained. Their physicochemical properties, including water solubility, surface activity, moisture absorption, and thermotropic liquid crystalline behavior, were investigated. The liquid crystal texture of alkoxyethyl β-D-maltosides (n = 7−16) has a fan-shaped focal conic texture. Furthermore, decoxyethyl β-D-maltoside had the strongest foaming characteristic and the best foam stability. Moreover, dodecoxyethyl β-D-maltoside (4f, n =12) had stronger emulsifying activity in the rapeseed oil/water system. Finally, CTAC/4f binary surfactants had an obvious synergistic effect. Such β-D-maltosides should have good application prospects in the future.

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Enhanced Liposomal Encapsulation of Ascorbic Acid by the Liquid Crystal β-sitosteryl-β-D-glucopyranoside

Cited by 6 publications

References 6 publications

Synthesis, Physical Properties, and In Vitro-Simulated Gastrointestinal Digestion of Hydrophilic β-Sitosterol Sugar Esters

Synthesis, Physical Properties, and In Vitro-Simulated Gastrointestinal Digestion of Hydrophilic β-Sitosterol Sugar Esters

The state of nanomedicine in Sri Lanka: challenges and opportunities

Water Solubility and Surface Activity of Alkoxyethyl β-d-Maltosides

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