Enhanced functional responsiveness of the dopaminergic system—the mechanism of anti-immobility effects of antidepressants in the behavioural despair test in the rat

Delini‐Stula, A.; Radeke, E.; Riezen, H. van

doi:10.1016/0028-3908(88)90122-0

Cited by 43 publications

(14 citation statements)

References 10 publications

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“…2). We also tested drugs that show false effects in the immobility time measurements (Delini-Stula et al, 1988;Lucki, 1997) and found that these drugs have false effects in both scoring methods, but the false effects were less prominent when using the joystick scoring.…”

Section: Discussionmentioning

confidence: 97%

“…Tricyclic antidepressants, monoamine oxidase inhibitors, and atypical antidepressants such as mianserine and iprindole, are all effective in this paradigm (Borsini and Meli, 1988). However, there are several shortcomings with the traditional type of measurement and several compounds have been recognized as false positive (Borsini and Meli, 1988;Delini-Stula et al, 1988;Panconi et al, 1993) or negative (Lucki, 1997). In his original paper Porsolt describe the immobility posture as those movements necessary only to keep the animal's head above the water (Porsolt et al, 1977).…”

Section: Introductionmentioning

confidence: 96%

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Behavioral analysis during the forced swimming test using a joystick device

Gersner

Dar

Shabat-Simon

et al. 2005

Journal of Neuroscience Methods

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 96%

Behavioral analysis during the forced swimming test using a joystick device

Gersner

Dar

Shabat-Simon

et al. 2005

Journal of Neuroscience Methods

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“…Amitriptyline, mianserin, desipramine, and fluoxetine have an antidepressant effect in the FST when chronically administered at a particular dose, but this same dose does not have an antidepressant effect when administered acutely [4849]. Another study indicated that some drugs, such as mepyramine and promethazine, are effective with acute treatment but not with chronic treatment [50]. These findings suggest that the mechanism involved in the imipramine-induced anti-immobility effect in the FST is different in the chronic and acute models.…”

Section: Discussionmentioning

confidence: 99%

Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats

Kawai¹,

Kodaira²,

Tanaka³

et al. 2018

Journal of Circadian Rhythms

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The pathogenesis and therapeutics of depression are linked to the operation of the circadian system. Here, we studied the chronopharmacological action of a tricyclic antidepressant, imipramine. Male adult Wistar–Hannover rats were administered imipramine acutely or chronically in the morning or in the evening. The antidepressant action of imipramine was analyzed using the forced swim test (FST). A single dose of imipramine (30 mg/kg) in the morning, but not in the evening, reduced immobility and increased climbing in the FST. The plasma concentrations of imipramine and its metabolite, desipramine, were slightly higher in the morning than in the evening, which might explain the dosing time-dependent action of imipramine. Next, we analyzed the effect of chronic imipramine treatment. Rats received imipramine in the morning or in the evening for 2 weeks. The morning treatment resulted in larger effects in the FST than the evening treatment, and was effective at a dose that was ineffective when administered acutely. The levels of brain α-adrenergic receptors tended to decrease after chronic imipramine treatment. Imipramine might interact with noradrenergic neurons, and this interaction might chronically alter receptor expression. This alteration seemed greater in the morning than in the evening, which might explain the dosing time-dependent action of imipramine.

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“…The role of H 1 R and H 2 R in the effects of histamine on depression is less clear. While in the Lamberti study, the H 1 R agonists 2-(3-trifluoromethylphenyl)histamine and 2thiazolylethylamine showed antidepressant-like activity [Lamberti et al, 1998] and H 1 R binding was shown to be decreased in the frontal and anterior cingulated cortex of depressed patients [Kano et al, 2004], the H 1 R antagonist mepyramine showed antidepressantlike activity in other studies [Delini-Stula et al, 1988;Noguchi et al, 2002]. Similarly, the H 1 R antagonist terfenadine showed antidepressant-like activity in the olfactory bulbectomized model of depression [Song et al, 1996].…”

Section: Role Of Histamine In Depressionmentioning

confidence: 96%

Histamine receptors as potential therapeutic targets to treat anxiety and depression

Raber

2005

Drug Development Research

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Increasing evidence supports a role for histamine in anxiety and depression. In most studies, histamine and stimulation of the histamine H 1 receptor (H 1 R) or blockade of the histamine H 2 receptor (H 2 R) increase measures of anxiety. In contrast, in most studies histamine reduces depression-like activity, which might be related to effects of histamine on waking. These effects of histamine on anxiety and depression make histamine receptor ligands attractive therapeutic targets. As most studies assessing the potential of histamine receptor ligands on depression did not exclude potential effects of these ligands on locomotor activity, more studies are warranted to determine the exact role of histamine receptor subtypes in depression. The effects of histamine-mediated signaling on anxiety and depression should also be considered in assessments of the potential of histamine H 3 receptor (H 3 R) ligands for conditions characterized by cognitive impairments as well as noncognitive behavioral impairments. Drug Dev. Res. 65:126-132, 2005.

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Enhanced functional responsiveness of the dopaminergic system—the mechanism of anti-immobility effects of antidepressants in the behavioural despair test in the rat

Cited by 43 publications

References 10 publications

Behavioral analysis during the forced swimming test using a joystick device

Behavioral analysis during the forced swimming test using a joystick device

Time of Administration of Acute or Chronic Doses of Imipramine Affects its Antidepressant Action in Rats

Histamine receptors as potential therapeutic targets to treat anxiety and depression

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