Enhanced Electron-Transfer Reactivity of Cytochrome b5 by Dimethylsulfoxide and N,N’-Dimethylformamide

Fan, Chunhai; Lu, Jun; Zhang, Wenjun; Suzuki, I.; Li, Genxi

doi:10.2116/analsci.18.1031

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…DMF in the binary solvents could be a key factor for electrospinning because it has a high dielectric constant (36.71) and dipole moment (3.8 D). Therefore, it shows, as a second conductor,22, 23 an electrolyte behavior that dissociates positive and negative charges 24, 25. In the presence of the electric field, positive ions are generated on the polymer chains.…”

Section: Resultsmentioning

confidence: 99%

Influence of solvents on the formation of ultrathin uniform poly(vinyl pyrrolidone) nanofibers with electrospinning

Yang

Hong

et al. 2004

J Polym Sci B Polym Phys

303

173

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Although there have been many reports on the preparation and applications of various polymer nanofibers with the electrospinning technique, the understanding of synthetic parameters in electrospinning remains limited. In this article, we investigate experimentally the influence of solvents on the morphology of the poly(vinyl pyrrolidone) (PVP) micro/nanofibers prepared by electrospinning PVP solution in different solvents, including ethanol, dichloromethane (MC) and N,N‐dimethylformamide (DMF). Using 4 wt % PVP solutions, the PVP fibers prepared from MC and DMF solvents had a shape like a bead‐on‐a‐string. In contrast, smooth PVP nanofibers were obtained with ethanol as a solvent although the size distribution of the fibers was somewhat broadened. In an effort to prepare PVP nanofibers with small diameters and narrow size distributions, we developed a strategy of using mixed solvents. The experimental results showed that when the ratio of DMF to ethanol was 50:50 (w/w), regular cylindrical PVP nanofibers with a diameter of 20 nm were successfully prepared. The formation of these thinnest nanofibers could be attributed to the combined effects of ethanol and DMF solvents that optimize the solution viscosity and charge density of the polymer jet. In addition, an interesting helical‐shaped fiber was obtained from 20 wt % PVP solution in a 50:50 (w/w) mixed ethanol/DMF solvent. © 2004 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 42: 3721–3726, 2004

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Section: Resultsmentioning

confidence: 99%

Influence of solvents on the formation of ultrathin uniform poly(vinyl pyrrolidone) nanofibers with electrospinning

Yang

Hong

et al. 2004

J Polym Sci B Polym Phys

303

173

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“…Results of experiments, albeit conducted under distinctly non-biological conditions, are also adduced in enthusiastic support. [11,[18][19][20] In a highly reducing environment in DMSO, a solvent that actually enhances electron-transfer processes involving redox-active biomolecules such as hemoglobin, [27,28] heme is efficiently alkylated by arte- misinins. The heme alkylates are held either to inhibit hemozoin formation so as to cause buildup within the food vacuole of the ferrous heme, which is toxic to the parasite, [29] or alternatively, are nominated as the actual antimalarial agents.…”

Section: Discussionmentioning

confidence: 99%

Interaction of Artemisinins with Oxyhemoglobin Hb–Fe^II, Hb–Fe^II, CarboxyHb–Fe^II, Heme–Fe^II, and Carboxyheme Fe^II: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

Coghi¹,

Basilico

Taramelli

et al. 2009

ChemMedChem

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In line with the enhancement of antimalarial activities of the current clinical artemisinins against parasites cultured under CO, the artemisinins are unaffected in vitro by carboxyhemoglobin (CO-Hb-Fe(II)) or CO-heme-Fe(II), but are competitively decomposed by Hb-Fe(II) or heme-Fe(II). In the latter case, the heme studies are greatly facilitated by solubilization of the heme in aqueous medium by use of arginine. None of the Hb species has an appreciable effect on artemisone, or on other aminoartemisinins, and antimalarial activities are either less affected or remain essentially unchanged against parasites cultured under standard microaerophilic conditions or under CO. The findings not only indicate that artemisinins do not require Hb-Fe(II) or heme-Fe(II) for promotion of antimalarial activity, but are also important in relation to the therapy of severe/complicated or cerebral malaria.

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“…125 Analogous benets from the solvency of DMSO have been reported in studies of proteins, including reducing binding affinities of proteins, 130 protein unfolding, 131,132 DMSO affecting protein charge, 130 and aiding in electron transfer. [133][134][135] While mediators and aprotic solvents can greatly improve the electrode response of polyelectrolytes like proteins and NOM, other advances in electrochemical methodology can also have signicant benets. One such opportunity for method renement concerns the working electrode composition (e.g., various forms of carbon vs. noble metals) and conguration (e.g., micro vs. reticulated).…”

Section: Introductionmentioning

confidence: 99%

Electrochemical characterization of natural organic matter by direct voltammetry in an aprotic solvent

Pavitt

Tratnyek

2019

Environ. Sci.: Processes Impacts

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Enhanced Electron-Transfer Reactivity of Cytochrome b5 by Dimethylsulfoxide and N,N’-Dimethylformamide

Cited by 9 publications

References 27 publications

Influence of solvents on the formation of ultrathin uniform poly(vinyl pyrrolidone) nanofibers with electrospinning

Influence of solvents on the formation of ultrathin uniform poly(vinyl pyrrolidone) nanofibers with electrospinning

Interaction of Artemisinins with Oxyhemoglobin Hb–Fe^II, Hb–Fe^II, CarboxyHb–Fe^II, Heme–Fe^II, and Carboxyheme Fe^II: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

Electrochemical characterization of natural organic matter by direct voltammetry in an aprotic solvent

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Enhanced Electron-Transfer Reactivity of Cytochrome b5 by Dimethylsulfoxide and N,N’-Dimethylformamide

Cited by 9 publications

References 27 publications

Influence of solvents on the formation of ultrathin uniform poly(vinyl pyrrolidone) nanofibers with electrospinning

Influence of solvents on the formation of ultrathin uniform poly(vinyl pyrrolidone) nanofibers with electrospinning

Interaction of Artemisinins with Oxyhemoglobin Hb–FeII, Hb–FeII, CarboxyHb–FeII, Heme–FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

Electrochemical characterization of natural organic matter by direct voltammetry in an aprotic solvent

Contact Info

Product

Resources

About

Interaction of Artemisinins with Oxyhemoglobin Hb–Fe^II, Hb–Fe^II, CarboxyHb–Fe^II, Heme–Fe^II, and Carboxyheme Fe^II: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria