Enhanced efficacy of a Cu2+ complex of curcumin against Gram-positive and Gram-negative bacteria: Attributes of complex formation

Kumar, Prince; Saha, Tanmoy; Behera, Swastik; Gupta, Shalini; Das, Saurabh; Mukhopadhyay, Kasturi

doi:10.1016/j.jinorgbio.2021.111494

Cited by 12 publications

(6 citation statements)

References 65 publications

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“…Consistently, the synergistic activity of curcumin and silver/copper nanoparticles (NPs) was detected against the cell growth and biofilm formation of S. aureus and P. aeruginosa compared to curcumin, AgNPs or CuNPs alone [113]. These marked synergistic effects may be related to the improvement of curcumin or intracellular uptake of curcumin [114].…”

Section: Curcumin and Metalsmentioning

confidence: 80%

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

Dai

Lin

et al. 2022

Antioxidants

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The rapid spread of antibiotic resistance and lack of effective drugs for treating infections caused by multi-drug resistant bacteria in animal and human medicine have forced us to find new antibacterial strategies. Natural products have served as powerful therapeutics against bacterial infection and are still an important source for the discovery of novel antibacterial drugs. Curcumin, an important constituent of turmeric, is considered safe for oral consumption to treat bacterial infections. Many studies showed that curcumin exhibited antibacterial activities against Gram-negative and Gram-positive bacteria. The antibacterial action of curcumin involves the disruption of the bacterial membrane, inhibition of the production of bacterial virulence factors and biofilm formation, and the induction of oxidative stress. These characteristics also contribute to explain how curcumin acts a broad-spectrum antibacterial adjuvant, which was evidenced by the markedly additive or synergistical effects with various types of conventional antibiotics or non-antibiotic compounds. In this review, we summarize the antibacterial properties, underlying molecular mechanism of curcumin, and discuss its combination use, nano-formulations, safety, and current challenges towards development as an antibacterial agent. We hope that this review provides valuable insight, stimulates broader discussions, and spurs further developments around this promising natural product.

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Section: Curcumin and Metalsmentioning

confidence: 80%

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

Dai

Lin

et al. 2022

Antioxidants

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“…According to the American Society for Testing and Materials, E2524-08(2013) active standard, hemolysis should not be greater than 5% for any potential biomaterial or drug to be non-toxic. 73 Although earlier studies give evidence of the non-toxic behavior of Curc, Cu-and Mn-Curc complexes towards RBCs, [74][75][76][77] the effect of all of these MCCs on RBCs has not been widely studied. We found that at low concentrations all these compounds showed non-hemolytic behavior (Fig.…”

Section: Hemolytic Activity In Human Erythrocytesmentioning

confidence: 99%

Transition metallo-curcumin complexes: a new hope for endometriosis?

et al. 2022

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“…It has been reported that CUR and its derivatives play a critical role in inhibiting the mitogen-activated protein kinase (MAPK) signaling pathway and blocking the nuclear factor kappa-B (NF-kB) p65 transferring into nucleus, and thus inhibit the macrophages activation [ 25 ]. In addition, CUR can also inhibit bacterial growth and reproduction by destroying the permeability of bacterial cell membranes [ 26 ]. Moreover, the addition of CUR in the feed can improve the beneficial effects of probiotics and regulates gut microbiota, predominantly increasing bile acids (BA) metabolism and short-chain fatty acid production associated microbiota, which subsequently increases hepatic cholesterol 7-alpha hydroxylase expression and BA synthesis [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Current Development and Future Application Prospects of Plants-Derived Polyphenol Bioactive Substance Curcumin as a Novel Feed Additive in Livestock and Poultry

Pan

Yan

Chen

et al. 2022

IJMS

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Curcumin (CUR) is a kind of natural orange-yellow phenolic compound mainly extracted from the stems and roots of turmeric plants and other species in the genus Curcuma, furthermore, it is also the most important active ingredient exerting pharmacological functions in turmeric. In recent years, CUR has been frequently reported and has attracted widespread attention from scholars all over the world due to its numerous biological functions and good application prospects, such as anti-inflammatory, anticancer, antioxidant and providing lipid-lowering effects, etc. In addition, adding a certain dose of CUR to livestock and poultry feed is important for animal growth and development, which plays a key role in animal metabolism, reproduction, immunity and clinical health care. This review aims to summarize, based on the published papers and our own observations, the physical and chemical properties and the biological functions of the plant-derived bioactive ingredient CUR, especially regarding the latest research progress in regulating intestinal health as well as its current development and future application prospects in livestock and poultry as a novel feed additive, so as to provide theoretical and practical references for the further study of the application of CUR as a novel feed additive and a potential new antibiotic substitute, thereby improving the research field of plant-derived bioactive ingredients and promoting the healthy development of livestock and poultry.

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Enhanced efficacy of a Cu2+ complex of curcumin against Gram-positive and Gram-negative bacteria: Attributes of complex formation

Cited by 12 publications

References 65 publications

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

Transition metallo-curcumin complexes: a new hope for endometriosis?

Current Development and Future Application Prospects of Plants-Derived Polyphenol Bioactive Substance Curcumin as a Novel Feed Additive in Livestock and Poultry

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