Enhanced diltiazem bioavailability after oral administration of diltiazem with quercetin to rabbits

Choi, Jun‐Shik; Li, Xiuguo

doi:10.1016/j.ijpharm.2004.12.004

Cited by 60 publications

(33 citation statements)

References 31 publications

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“…Thus, it could be inferred that changes in plasma concentration are because of intestinal P-gp blockade caused by quercetin. These results are also well-corroborated with the previously reported data wherein quercetin has modulated pharmacokinetics of various P-gp substrates belonging to different therapeutic categories in different animals (Choi et al, 2004a;Choi and Han, 2005;Choi et al, 2004b;Choi and Li, 2005;Choi and Shin, 2005;Dupuy et al, 2003;Hsiu et al, 2002;Shin et al, 2006;Wang et al, 2004).…”

Section: Discussionsupporting

confidence: 90%

Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: Possible contribution of P-glycoprotein

et al. 2008

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Section: Discussionsupporting

confidence: 90%

Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: Possible contribution of P-glycoprotein

et al. 2008

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“…Absolute and relative bioavailability values of verapamil in the rabbits pretreated with quercetin were significantly higher ( P < 0.05) than verapamil alone group. [31] Similar results have been reported with pretreatment/co-treatment of quercetin with diltiazem,[32] paclitaxel,[33] digoxin,[34] doxorubicin,[35] and tamoxifen[36] Table 2.…”

Section: Other Bioenhancerssupporting

confidence: 77%

Bioenhancers from mother nature and their applicability in modern medicine

Randhawa

Kullar

Rajkumar³

2011

Int J App Basic Med Res

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Concept of bioenhancers or biopotentiators was first time reported in 1929 by Bose. A bioenhancer is an agent capable of enhancing bioavailability and efficacy of a drug with which it is co-administered, without any pharmacological activity of its own at therapeutic dose used. Development and consequent isolation of these molecules, such as piperine and quercetin, is considered as scientific breakthrough. A fixed drug combination (Risorine) of rifampicin, isoniazid, and piperine is the result of this research. It contains almost 60% less dose of rifampicin because of its increased bioavailability and it also prevents resistance. This concept is mentioned as yogvahi in ayurveda and was used to increase the effect of medicines by increasing oral bioavailability, decreasing adverse effects and to circumvent parenteral routes of drug administration. More such useful and economically viable drug combinations can be developed by integrating knowledge of time tested ayurveda with modern methods of research. This review is an account of these bioenhancers, available from the natural resources.

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“…Quercetin has exhibited a wide range of beneficial biological activities including antioxidant, radical scavenging, anti-inflammatory, anti-atherosclerotic, anti-tumoral and anti-viral effects [35] . Quercetin has been shown to increase bioavailability, blood levels and efficacy of a number of drugs including diltiazem, digoxin and epigallocatechin gallaate [36][37][38][39] .…”

Section: Future Prospectsmentioning

confidence: 99%