Enhanced Cell Survival of Gastric Cancer Cells By a Novel Gene URG4

Song, Jiugang; Xie, Hui; Lian, Zhaorui; Yang, Guitao; Du, Rui; Du, Yulei; Zou, Xingxing; Jin, Haifeng; Gao, Juan; Liu, Jie; Fan, Daiming

doi:10.1593/neo.06592

Cited by 47 publications

(48 citation statements)

References 14 publications

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“…Previously, we have analyzed the differentially expressed genes in the presence of HBxAg in HepG2 cells, a hepatoblastoma cell line, and showed that HBx upregulates the expression of a novel gene, URG4, which is differentially expressed in tumor compared to non-tumor liver specimens from HBV-infected HCC patients. Over-expression of URG4 in HepG2 and GES-1 cells promoted cell growth and survival in tissue culture and soft agar, and accelerated tumor development in nude mice, suggesting that URG4 may be associated with the onset of tumorigenesis (Satiroglu-Tufan et al, 2002;Song et al, 2006). Over-expression of URG4 in osteosarcoma tissues is well correlated with tumor recurrence and metastasis, as well as with the proliferative activity of osteosarcoma cells.…”

Section: Discussionmentioning

confidence: 97%

“…Previous publications of our group and others have revealed that URG4 over-expression stimulates cell growth in HepG2 and GES-1 cells (Satiroglu-Tufan et al, 2002;Song et al, 2006). Hence, experiments were designed to determine whether the inhibition of URG4 expression could suppress the growth of hepatocarcinoma cells.…”

Section: Rnai-mediated Urg4 Silencing Suppresses the Growth Of Hepg2mentioning

confidence: 99%

“…URG4 was strongly expressed in hepatitis B-infected liver and in HCC cells, where it costained with HBxAg, and was weakly expressed in uninfected liver, suggesting that URG4 was an effector of HBxAg in vivo. Over-expression of URG4 in HepG2 (Satiroglu-Tufan et al, 2002) and GES-1 cells (Song et al, 2006) promoted cell growth and survival in tissue culture and soft agar, and accelerated tumor development in nude mice, suggesting that URG4 may be associated with the onset of tumorigenesis. Over-expressed URG4 in osteosarcoma tissues is well correlated with tumor recurrence and metastasis, as well as with the proliferative activity of osteosarcoma cells.…”

Section: Introductionmentioning

confidence: 99%

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RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells

Şatıroğlu-Tufan¹,

Dodurga²,

D³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. Up-regulated gene 4 (URG4), stimulated by HBxAg, is a novel gene located on chromosome 7 (7p13). The full-length URG4 clone is 3.607 kb and encodes a polypeptide of 922 amino acids, with a molecular weight of 104 kDa (GeneID: 55665). It promotes cell growth, growth factor-independent survival, and anchorage-independent growth in HepG2 cells, and it accelerates tumor formation in nude mice. Hence, URG4 may be a natural effector of HBxAg and a putative oncogene that contributes to multi-step hepatocarcinogenesis. Cyclin D1 is frequently over-expressed in hepatocellular carcinoma, exhibiting a number of malignant phenotypes. We found that down-regulation of URG4 through RNA interference-mediated silencing suppressed cell proliferation in HepG2 cells. Over-expression of URG4 up-regulated cyclin D1 mRNA expression, whereas RNA interference-mediated URG4 silencing diminished cyclin D1 mRNA expression in HepG2 cells. The data suggest that URG4 may play an important role in the development of hepatocellular carcinoma by partially regulating the expression of cyclin D1 and has potential for use as a therapeutic target for hepatocellular carcinoma.

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Section: Discussionmentioning

confidence: 97%

Section: Rnai-mediated Urg4 Silencing Suppresses the Growth Of Hepg2mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells

Şatıroğlu-Tufan¹,

Dodurga²,

D³

et al. 2010

Genet. Mol. Res.

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show abstract

“…It may play an important role in the development of hepatocellular carcinoma by promoting hepatocellular growth and survival [5]. Previous data also indicated that URG4 was strongly expressed in gastric cancer [6]. In addition, Huang et al [7] demonstrated that the over-expression of URG4 in osteosarcoma tissues is well correlated with tumor recurrence and metastasis, as well as with the proliferative activity of osteosarcoma cells.…”

Section: Introductionmentioning

confidence: 99%

URG4 upregulation is associated with tumor growth and poor survival in epithelial ovarian cancer

Zhou

2012

Arch Gynecol Obstet

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“…It was suggested that URG4 may play a role in the development of carcinoma by regulating the expression of the cyclin D1 gene ( CCND1) [5]. URG4 has also been proposed as a therapeutic target in the treatment of carcinomas such as gastric cancer due to its implication in carcinogenesis [6]. …”

Section: Introductionmentioning

confidence: 99%

Higher Expression of the Novel Gene Upregulated Gene 4 in Two Acute Lymphoblastic Leukemia Patients with Poor Prednisolone Response

et al. 2012

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Elucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), which promotes cell growth and survival, is increased in different types of carcinomas including hepatocellular carcinoma, gastric cancer and osteosarcoma. Similarly, higher expression of URG4 and cyclin D1 gene might promote proliferation of the blast cells by causing escape from the G1 checkpoint and entry into the S phase. This study reports the high expression level of URG4 in 2 high-risk ALL patients for the first time in the literature. In conclusion, the higher expression of URG4 in our 2 patients suggests that URG4 might be involved in leukemogenesis. Future studies with a large number of high-risk ALL patients and cell culture studies are needed to demonstrate the exact role of URG4 in leukemogenesis.

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Enhanced Cell Survival of Gastric Cancer Cells By a Novel Gene URG4

Cited by 47 publications

References 14 publications

RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells

RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells

URG4 upregulation is associated with tumor growth and poor survival in epithelial ovarian cancer

Higher Expression of the Novel Gene Upregulated Gene 4 in Two Acute Lymphoblastic Leukemia Patients with Poor Prednisolone Response

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