volume 275, issue 1-2, P165-170 2004
DOI: 10.1016/j.ijpharm.2004.01.032
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Abstract: The purpose of this study was to investigate the effect of flavone on the bioavailability of paclitaxel orally coadministered in rats. Paclitaxel (40 mg/kg) and flavone (2, 10, 20 mg/kg) were orally administered to rats orally. The plasma concentration of paclitaxel with flavone increased significantly (P < 0.01) compared to that of paclitaxel control. Area under the plasma concentration-time curve (AUC) of paclitaxel with the dose of 2-20 mg/kg flavone was significantly (P < 0.05 at 10 mg/kg, P < 0.01 at 20 m…

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