Enhanced bactericidal toxicity of silver nanoparticles by the antibiotic gentamicin

Wang, Yanwen; Tang, Huan; Wu, Di; Liu, Dong; Liu, Yuanfang; Cao, Aoneng; Wang, Haifang

doi:10.1039/c6en00031b

Cited by 46 publications

(47 citation statements)

References 40 publications

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“…The results obtained from this study are consistent with that of other researches. Indeed, gentamycin plus Ag-NPs in several studies demonstrated enhanced or even synergistic antibacterial effect against (Barapatre, et al 2016;Chhibber, et al 2017;Ebrahimi, et al 2017;Jamaran and Zarif 2016;Katva, et al 2017;Mohamed, et al 2017;Panacek, et al 2015;Satapathy, et al 2017;Verma, et al 2017;Wang, et al 2016).Moreover, in a good agreement with reported data in the literature, penicillin (Ebrahimi, et al 2017;Panacek, et al 2015) in contrary to some studies (Deng, et al 2016;Natan and Banin 2017;Wang, et al 2016) and ciprofloxacin in the case of human strains (Mohamed, et al 2017;Yallappa, et al 2015) in accord with our data (Panacek, et al 2015) showed significant increase in antibacterial activities when conjugated with Ag-NPs. Furthermore, tetracycline (Deng, et al 2016;Ebrahimi, et al 2017;Natan and Banin 2017), amoxicillin (Mohamed, et al 2017), cephalosporin (Refat, et al 2017), erythromycin (Yallappa, et al 2015 showed partially increase in antibacterial activities in the presence of Ag-NPs.…”

Section: Discussionsupporting

confidence: 92%

Combined efficacy of silver nanoparticles and commercial antibiotics on different phylogenetic groups of Escherichia coli

Kazemnia

Ahmadi

Mardani

et al. 2019

J Hellenic Vet Med Soc

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Silver nanoparticles (Ag-NPs) can attach to flexible polymeric chains of antibiotics, hence it can be used in combination with antibiotics against resistant bacteria. In this study, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and MBC/MIC ratio of Ag-NPs and antibiotics (gentamicin, tetracycline, erythromycin, ciprofloxacin, nalidixic acid, cefixime, cephalexin, amoxicillin, ampicillin, and penicillin) were quantified against 50 Escherichia coli isolates (25 human urinary tract infection and 25 avian colibacillosis). All isolates had been assigned as four phylogenetic groups A, B1, B2, and D. The results showed that the majority of the human and broiler isolates belonged to phylogenetic groups A and B2. MBC/MIC ratio of Ag-NPs in combination with antibiotics was assessed. It was found that the MIC of the majority of broiler isolates to Ag-NPs was equal to or greater than 50 μg/ml. To conclude, a combination of penicillin and ciprofloxacin with Ag-NPs exhibited profound impact against isolates, the combinations might be applicable for treating multidrug-resistant bacteria.

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Section: Discussionsupporting

confidence: 92%

Combined efficacy of silver nanoparticles and commercial antibiotics on different phylogenetic groups of Escherichia coli

Kazemnia

Ahmadi

Mardani

et al. 2019

J Hellenic Vet Med Soc

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“…In addition, gentamicin molecules contain many active groups such as amino and hydroxyl, which react easily with Ag nanoparticles by chelation. 29,50 The complex (Ag-gentamicin) may further bind to DNA, preventing DNA unwinding. Also, the Ag-gentamicin could potentially keep a more stable structure, thus potentially leading to a longterm antibacterial activity.…”

Section: Discussionmentioning

confidence: 99%

Silver-loaded nanotubular structures enhanced bactericidal efficiency of antibiotics with synergistic effect in vitro and in vivo

Cheng

et al. 2017

IJN

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Antibiotic-resistant bacteria have become a major issue due to the long-term use and abuse of antibiotics in treatments in clinics. The combination therapy of antibiotics and silver (Ag) nanoparticles is an effective way of both enhancing the antibacterial effect and decreasing the usage of antibiotics. Although the method has been proved to be effective in vitro, no in vivo tests have been carried out at present. Herein, we described a combination therapy of local delivery of Ag and systemic antibiotics treatment in vitro in an infection model of rat. Ag nanoparticle-loaded TiO 2 nanotube (NT) arrays (Ag-NTs) were fabricated on titanium implants for a customized release of Ag ion. The antibacterial properties of silver combined with antibiotics vancomycin, rifampin, gentamicin, and levofloxacin, respectively, were tested in vitro by minimum inhibitory concentration (MIC) assay, disk diffusion assay, and antibiofilm formation test. Enhanced antibacterial activity of combination therapy was observed for all the chosen bacterial strains, including gram-negative Escherichia coli (ATCC 25922), gram-positive Staphylococcus aureus (ATCC 25923), and methicillin-resistant Staphylococcus aureus (MRSA; ATCC 33591 and ATCC 43300). Moreover, after a relative short (3 weeks) combinational treatment, animal experiments in vivo further proved the synergistic antibacterial effect by X-ray and histological and immunohistochemical analyses. These results demonstrated that the combination of Ag nanoparticles and antibiotics significantly enhanced the antibacterial effect both in vitro and in vivo through the synergistic effect. The strategy is promising for clinical application to reduce the usage of antibiotics and shorten the administration time of implant-associated infection.

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“…95, 268–275 Current ENM-based antibacterial applications usually rely on mechanisms acting through toxic ions, ROS, oxidative stress and membrane damage elicited by NPs (e.g. Ag, CuO and ZnO NPs, carbon nanotubes and graphene derivatives) bound to bacterial cell wall or taken up by bacterial cells.…”

Section: Discussionmentioning

confidence: 99%

NanoEHS beyond toxicity – focusing on biocorona

Lin

Mortimer

Chen

et al. 2017

Environ. Sci.: Nano

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The first phase of environmental health and safety of nanomaterials (nanoEHS) studies has been mainly focused on evidence-based investigations that probe the impact of nanoparticles, nanomaterials and nano-enabled products on biological and ecological systems. The integration of multiple disciplines, including colloidal science, nanomaterial science, chemistry, toxicology/immunology and environmental science, is necessary to understand the implications of nanotechnology for both human health and the environment. While strides have been made in connecting the physicochemical properties of nanomaterials with their hazard potential in tiered models, fundamental understanding of nano-biomolecular interactions and their implications for nanoEHS is largely absent from the literature. Research on nano-biomolecular interactions within the context of natural systems not only provides important clues for deciphering nanotoxicity and nanoparticle-induced pathology, but also presents vast new opportunities for screening beneficial material properties and designing greener products from bottom up. This review highlights new opportunities concerning nano-biomolecular interactions beyond the scope of toxicity.

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Enhanced bactericidal toxicity of silver nanoparticles by the antibiotic gentamicin

Abstract: The alteration of properties of nanomaterials in the environment may change the interaction of the nano–bio interface and the corresponding bio-responses.

Cited by 46 publications

References 40 publications

Combined efficacy of silver nanoparticles and commercial antibiotics on different phylogenetic groups of Escherichia coli

Combined efficacy of silver nanoparticles and commercial antibiotics on different phylogenetic groups of Escherichia coli

Silver-loaded nanotubular structures enhanced bactericidal efficiency of antibiotics with synergistic effect in vitro and in vivo

NanoEHS beyond toxicity – focusing on biocorona

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