Enhanced Antibacterial Potential of Naringin Loaded β Cyclodextrin Nanoparticles

Preparation, Physicochemical Characterization, and Antioxidant Activity of Naringin–Silk Fibroin–Alginate Microspheres and Application in Yogurt

“…Hussain et al prepared naringin-β-cyclodextrin nanoparticles and obtained, through in vitro study, that the maximum release of naringin was 81.3% at pH 7.0 and only 53.8% at pH 4.6. The maximum release time was 8.5 h under both pH conditions [ 6 ]. In our research, the release curves at various pH values were about similar and the cumulative release of naringin was up to 60% during 12 h.…”

“…As shown in Table 4 , the pH of yogurt decreased during the storage, and there was no significant difference between the pH of NY and CY on days 7 and 14. The pH value of the microspheres was always higher than that of the other two groups and decreased at a slower rate, which might have been due to the antibacterial activity of naringin and microencapsulated, sustained release properties [ 6 ].…”

“…Naringin (4′,5,7-trihydroxy flavanone 7-rhamno glucoside, Figure 1 A) is a natural polyphenol compound mainly present in the peel and flesh of grapefruit, orange, and lime [ 1 , 2 ]. Naringin possesses a variety of biological and pharmacological properties, such as antioxidant, anti-inflammatory, antibacterial, osteoblast induction, and nerve protection [ 3 , 4 , 5 , 6 ]. However, its pH sensitivity, oxidability, poor solubility, and bitter flavor limit its application in food field [ 7 ].…”

“…However, its pH sensitivity, oxidability, poor solubility, and bitter flavor limit its application in food field [ 7 ]. To overcome these shortcomings, some studies investigated incorporating naringin into microcapsules, inclusion complexes, and nanoparticles [ 6 , 8 , 9 ]. Hussain et al prepared naringin-loaded β-cyclodextrin nanoparticles to improve its bactericidal ability [ 6 ].…”

“…To overcome these shortcomings, some studies investigated incorporating naringin into microcapsules, inclusion complexes, and nanoparticles [ 6 , 8 , 9 ]. Hussain et al prepared naringin-loaded β-cyclodextrin nanoparticles to improve its bactericidal ability [ 6 ]. Nallamuthu et al encapsulated naringin in zein/caseinate biopolymers, and the formulation had higher anti-adipogenic activity in 3T3-L1 cells comparing with the native form [ 10 ].…”