Enhanced Antibacterial Activity of Silver/Polyrhodanine-Composite-Decorated Silica Nanoparticles

Abstract

This work describes the synthesis of silver/polyrhodanine-composite-decorated silica nanoparticles and their antibacterial activity. Polymerization of polyrhodanine proceeded preferentially on the surface of the silica nanoparticles where Ag(+) ions were located. In addition, the embedded Ag(+) ions were reduced to form metallic Ag nanoparticles; consequently, silver/polyrhodanine-composite nanoparticles (approximately 7 nm in diameter) were formed on the surface of the silica nanoparticles. The resulting nanostructure was investigated using electron microscopy, Fourier-transform infrared spectroscopy, ultraviolet-visible spectroscopy, and X-ray photoelectron spectroscopy. The silver/polyrhodanine-nanocomposite-decorated silica nanoparticles exhibited excellent antimicrobial activity toward gram-negative Escherichia coli and gram-positive Staphylococcus aureus because of the antibacterial effects of the silver nanoparticles and the polyrhodanine. The silver/polyrhodanine-composite nanoparticles may therefore have potential for use as a long-term antibacterial agent.

Shape engineering boosts antibacterial activity of chitosan coated mesoporous silica nanoparticle doped with silver: a mechanistic investigation

“…52 Recently, in two studies,diffrent design of silica nanoparticles has been found effective in killing bacterial cells without damaging human cells. 53,54 Tank et al found that silica coated silicon nanotubes have excellent antimicrobial activity against both Gram-positive and Gram-negative bacteria. 52 In a separate study, Song et al also showed the antimicrobial effect 10 | J.…”

“…54 Another characteristic feature of silica NP makes them popular is their dispersibility in the aqueous media; a property which most of the nanoparticles lack. 55 There is no doubt that MSPs have great potential in the field of antibacterial nanomedicine, but the bottleneck is insufficient mechanistic studies on how MSP kills bacteria.…”

“…18 This is highly important in protecting the environment and beneficial bacteria from the metal nanoparticles for the sake of the ecosystem. 19 Recently, the antibacterial activity of silver-silica nanocomposites was demonstrated 20 however, detailed understanding of the designed material and the exact mechanism of action is still elusive. Very little insight into the antibacterial properties of silica nanoparticles exists in the literature.…”

Toxicity of some metal oxides nanoparticles on male rats with respect to biochemical and histological changes

“…We found that the studied three metal oxides nanoparticles indeed exhibit much low toxicity, and that their low toxicity can be attributed to their tendency to aggregate in solution which results in limited interaction between the nanoparticles and cell walls of the test organisms (Ching -Ng et al, 2015). Recently, in two studies, different designs of silica nanoparticles have not damage human cells (Liong et al, 2009;Song et al, 2013). Histopathological examination revealed no abnormalities in any tissues (liver, kidney, large intestine, brain, lungs, spleen, heart, stomach and small intestine) after orally exposing silica nanoparticles for 28 days at a daily dose of 2.5 mg. (Mebert et al, 2017).…”

Preparation of silver and copper nanoparticles in presence of ascorbic acid and investigation of their antibacterial activity

“…So far it has been reported the use of ascorbic acid as a reducing agent for metal NPs synthesis by using microwave irradiation (Qin et al, 2010;Chekin and Ghasemi, 2014). Silver NPs are of interest because of their antibacterial activity and localized surface plasmon resonance properties (Song et al, 2013;Panáček et al, 2006;Amendola et al, 2010; * Corresponding author: bojana.laban@pr.ac.rs Mogensen & Kneipp, 2014). Developing the route of synthesis enabled the control of desired size, shape, and capping agents.…”