Engineering triple internal electric fields in Ag NWs@BaTiO3 composites for ultrasonic-visible-light driven antibacterial activity

Shu, Guoqiang; Lin, Yaqi; Zhong, Rui; Su, Xiaofan; Guo, Sheng; Wang, Chao; Zhou, Changan; Song, Lei; Xie, Li; Ma, Kui; Yue, Hairong

doi:10.1016/j.cej.2023.142310

Cited by 19 publications

(10 citation statements)

References 57 publications

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“…Additionally, the splitting of the 3d doublet is about 6.0 eV. These results unambiguously demonstrate that the encapsulated Ag element mainly belongs to metallic silver (Ag 0 ) . The inductively coupled plasma-optical emission spectrometry (ICP-OES) measurement showed that the Ag content in Ag NPs@ACM-1 is about 4.91%, which further indicates the successful loading of Ag NPs into ACM-1 (Table S1).…”

Section: Resultssupporting

confidence: 56%

“…These results unambiguously demonstrate that the encapsulated Ag element mainly belongs to metallic silver (Ag 0 ). 29 The inductively coupled plasmaoptical emission spectrometry (ICP-OES) measurement showed that the Ag content in Ag NPs@ACM-1 is about 4.91%, which further indicates the successful loading of Ag NPs into ACM-1 (Table S1). Ag NPs@ACM-1 has a uniform morphology, which is block-shaped, as observed by scanning electron microscopy (SEM, Figure 1f) and transmission electron microscopy (TEM, Figure 1g).…”

Section: Resultsmentioning

confidence: 92%

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Silver Nanoparticle-Loaded Titanium-Based Metal–Organic Framework for Promoting Antibacterial Performance by Synergistic Chemical–Photodynamic Therapy

Zhan,

Zeng,

et al. 2023

Inorg. Chem.

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The abuse of antibiotics leads to an increasing emergence of drug-resistant bacteria, which not only causes a waste of medical resources but also seriously endangers people's health and life safety. Therefore, it is highly desirable to develop an efficient antibacterial strategy to reduce the reliance on traditional antibiotics. Antibacterial photodynamic therapy (aPDT) is regarded as an intriguing antimicrobial method that is less likely to generate drug resistance, but its efficiency still needs to be further improved. Herein, a robust titanium-based metal−organic framework ACM-1 was adopted to support Ag nanoparticles (NPs) to obtain Ag NPs@ACM-1 for boosting antibacterial efficiency via synergistic chemical−photodynamic therapy. Apart from the intrinsic antibacterial nature, Ag NPs largely boost ROS production and thus improve aPDT efficacy. As a consequence, Ag NPs@ACM-1 shows excellent antibacterial activity under visible light illumination, and its minimum bactericidal concentrations (MBCs) against E. coli, S. aureus, and MRSA are as low as 39.1, 39.1, and 62.5 μg mL −1 , respectively. Moreover, to expand the practicability of Ag NPs@ACM-1, two (a dense and a loose) Ag NPs@ ACM-1 films were readily fabricated by simply dispersing Ag NPs@ACM-1 into heated aqueous solutions of edible agar and sequentially cooling through heating or freeze-drying, respectively. Notably, these two films are mechanically flexible and exhibit excellent antibacterial activities, and their antimicrobial performances can be well retained in their recyclable and remade films. As agar is nontoxic, degradable, inexpensive, and ecosustainable, the dense and loose Ag NPs@ACM-1 films are potent to serve as recyclable and degradable antibacterial plastics and antibacterial dressings, respectively.

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Section: Resultssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 92%

Silver Nanoparticle-Loaded Titanium-Based Metal–Organic Framework for Promoting Antibacterial Performance by Synergistic Chemical–Photodynamic Therapy

Zhan,

Zeng,

et al. 2023

Inorg. Chem.

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“…The detailed information is described in the previous work of this group. 45 2.4. Synergistic Piezo-photocatalytic Degradation Performance Testing.…”

Section: Methodsmentioning

confidence: 99%

“…More details regarding the experimental procedure can be found in the previous work. 45 2.6. Antibacterial Studies.…”

Section: Methodsmentioning

confidence: 99%

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Low-Cytotoxic Core–Sheath ZnO NWs@TiO_2–xN_y Triggered Piezo-photocatalytic Antibacterial Activity

Guo,

Shu,

Luo

et al. 2024

ACS Appl. Mater. Interfaces

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Sonophotodynamic antimicrobial therapy (SPDAT) is recognized as a highly efficient biomedical treatment option, known for its versatility and remarkable healing outcomes. Nevertheless, there is a scarcity of sonophotosensitizers that demonstrate both low cytotoxicity and exceptional antibacterial effectiveness in clinical applications. In this paper, a novel ZnO nanowires (NWs)@TiO 2−x N y core−sheath composite was developed, which integrates the piezoelectric effect and heterojunction to build dual built-in electric fields. Remarkably, it showed superb antibacterial effectiveness (achieving 95% within 60 min against S. aureus and ∼100% within 40 min against E. coli, respectively) when exposed to visible light and ultrasound. Due to the continuous interference caused by light and ultrasound, the material's electrostatic equilibrium gets disrupted. The modification in electrical properties facilitates the composite's ability to attract bacterial cells through electrostatic forces. Moreover, Zn−O−Ti and Zn−N−Ti bonds formed at the interface of ZnO NWs@TiO 2−x N y , further enhancing the dual internal electric fields to accelerate the excited carrier separation to generate more reactive oxygen species (ROS), and thereby boosting the antimicrobial performance. In addition, the TiO 2 layer limited Zn 2+ dissolution into solution, leading to good biocompatibility and low cytotoxicity. Lastly, we suggest a mechanistic model to offer practical direction for the future development of antibacterial agents that are both low in toxicity and high in efficacy. In comparison to the traditional photodynamic therapy systems, ZnO NWs@TiO 2−x N y composites exhibit super piezophotocatalytic antibacterial activity with low toxicity, which shows great potential for clinical application as an antibacterial nanomaterial.

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Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

He,

Feng,

Hao

et al. 2024

Adv Funct Materials

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Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic therapy (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for antibacterial treatment under the stimulation of light/ultrasound, which have the characteristics of broad‐spectrum antibacterial properties, low drug‐resistance, and effective targeting of infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers of sensitizers. They enhance the stability and permeability of sensitizers, improve targeting of sensitizers, strengthen photodynamic/sonodynamic properties of sensitizers (modification of sensitizers absorption efficiency and light/ultrasonic response stress by modulation of nanoparticle shape, size, and structure). Also, they improve modifiability of sensitizers (controlling the release rate and time of the sensitizer as needed to optimize the therapeutic effect), enhance programmability and multifunctionality of sensitizers (flexible application of nanotechnology for designing sensitizers with multiple functions, such as drug delivery, targeted therapy, and therapeutic monitoring), and expand possibilities for combination therapies (the nano‐carriers can be loaded with other therapeutic agents, enabling combination therapies). Nanomaterials are expected to further promote the development of aPDT/aSDT and achieve improved antibacterial effects. This review summarizes the progress in nanomaterials in aPDT/aSDT in recent years and based on the current development strategies to provide a theoretical reference for the application of nanomaterials in aPDT/aSDT.

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Engineering triple internal electric fields in Ag NWs@BaTiO3 composites for ultrasonic-visible-light driven antibacterial activity

Cited by 19 publications

References 57 publications

Silver Nanoparticle-Loaded Titanium-Based Metal–Organic Framework for Promoting Antibacterial Performance by Synergistic Chemical–Photodynamic Therapy

Silver Nanoparticle-Loaded Titanium-Based Metal–Organic Framework for Promoting Antibacterial Performance by Synergistic Chemical–Photodynamic Therapy

Low-Cytotoxic Core–Sheath ZnO NWs@TiO_2–xN_y Triggered Piezo-photocatalytic Antibacterial Activity

Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

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Engineering triple internal electric fields in Ag NWs@BaTiO3 composites for ultrasonic-visible-light driven antibacterial activity

Cited by 19 publications

References 57 publications

Silver Nanoparticle-Loaded Titanium-Based Metal–Organic Framework for Promoting Antibacterial Performance by Synergistic Chemical–Photodynamic Therapy

Silver Nanoparticle-Loaded Titanium-Based Metal–Organic Framework for Promoting Antibacterial Performance by Synergistic Chemical–Photodynamic Therapy

Low-Cytotoxic Core–Sheath ZnO NWs@TiO2–xNy Triggered Piezo-photocatalytic Antibacterial Activity

Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

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Product

Resources

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Low-Cytotoxic Core–Sheath ZnO NWs@TiO_2–xN_y Triggered Piezo-photocatalytic Antibacterial Activity