Engineering the Spark Into Bioelectronic Medicine

Sanjuán-Alberte, Paola; Rawson, Frankie J.

doi:10.4155/tde-2019-0008

Cited by 11 publications

(11 citation statements)

References 25 publications

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“…This can limit their practical applications when used in an in vivo setting. Wireless nanobioelectronics have emerged as an appealing solution to this, offering a new technological approach to seamlessly integrate and fuse electronic components with cells and tissues (Sanjuan‐Alberte & Rawson, 2019). In this section, we will provide an overview of the current strategies to develop wireless nanobioelectronic and the use of nanoparticles to actuate cell behavior, all of which are being used to develop novel tools for applications in bioelectronic medicine.…”

Section: Wireless Nanobioelectronic Toolsmentioning

confidence: 99%

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

Gibney

Hicks

Robinson

et al. 2021

WIREs Nanomed Nanobiotechnol

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Bioelectronic medicine aims to interface electronic technology with biological components and design more effective therapeutic and diagnostic tools. Advances in nanotechnology have moved the field forward improving the seamless interaction between biological and electronic components. In the lab many of these nanobioelectronic devices have the potential to improve current treatment approaches, including those for cancer, cardiovascular disorders, and disease underpinned by malfunctions in neuronal electrical communication. While promising, many of these devices and technologies require further development before they can be successfully applied in a clinical setting. Here, we highlight recent work which is close to achieving this goal, including discussion of nanoparticles, carbon nanotubes, and nanowires for medical applications. We also look forward toward the next decade to determine how current developments in nanotechnology could shape the growing field of bioelectronic medicine. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > Biosensing

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Section: Wireless Nanobioelectronic Toolsmentioning

confidence: 99%

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

Gibney

Hicks

Robinson

et al. 2021

WIREs Nanomed Nanobiotechnol

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“…[ 331 ] More recently they have found application in bioelectronic medicine, where the electrical modulation of nerve activity is used to treat pathological conditions. [ 332–334 ] The anatomical structure of the peripheral nervous system is a challenge for bioelectronic interfaces. Peripheral nerves undergo relatively huge mechanical strain as a result of limb motion, [ 335 ] with underlying nerve fibers sheathed in several fatty layers that permit fascicles (bundles of axons) to slide past each other.…”

Section: In Vivo Applicationsmentioning

confidence: 99%

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Higgins

Fiego

Patrick

et al. 2020

Adv Materials Technologies

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Conjugated polymers exhibit interesting material and optoelectronic properties that make them well‐suited to the development of biointerfaces. Their biologically relevant mechanical characteristics, ability to be chemically modified, and mixed electronic and ionic charge transport are captured within the diverse field of organic bioelectronics. Conjugated polymers are used in a wide range of device architectures, and cell and tissue scaffolds. These devices enable biosensing of many biomolecules, such as metabolites, nucleic acids, and more. Devices can be used to both stimulate and sense the behavior of cells and tissues. Similarly, tissue interfaces permit interaction with complex organs, aiding both fundamental biological understanding and providing new opportunities for stimulating regenerative behaviors and bioelectronic based therapeutics. Applications of these materials are broad, and much continues to be uncovered about their fundamental properties. This report covers the current understanding of the fundamentals of conjugated polymer biointerfaces and their interactions with biomolecules, cells, and tissues in the human body. An overview of current materials and devices is presented, along with highlighted major in vivo and in vitro applications. Finally, open research questions and opportunities are discussed.

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“…BEM is a field that encompasses any use of electronic devices to interface with biological tissue for the purpose of treating disease (Olofsson & Tracey, 2017;Sanjuan-Alberte & Rawson, 2019). As BEM continues to evolve, so too will bionic humans, people that have had the functionality of a lost body part completely replaced by an electronic device.…”

Section: Introduction: Evolution Of Bioelectronicsmentioning

confidence: 99%

“…The aim of this article is to review what the literature has to say on the subject of nerve regeneration in vivo and the electrophysiology of the reinnervated tissue. Much of BEM is focused on using bionics to treat nerve damage or malfunctions (Sanjuan-Alberte & Rawson, 2019). Therefore, it is important for biomedical engineers to understand the electrical considerations that must be made when interfacing with tissue after its recovery from major trauma.…”

Section: Introduction: Evolution Of Bioelectronicsmentioning

confidence: 99%

Cut wires: The Electrophysiology of Regenerated Tissue

Lowe

Thakor

2021

Bioelectron Med

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When nerves are damaged by trauma or disease, they are still capable of firing off electrical command signals that originate from the brain. Furthermore, those damaged nerves have an innate ability to partially regenerate, so they can heal from trauma and even reinnervate new muscle targets. For an amputee who has his/her damaged nerves surgically reconstructed, the electrical signals that are generated by the reinnervated muscle tissue can be sensed and interpreted with bioelectronics to control assistive devices or robotic prostheses. No two amputees will have identical physiologies because there are many surgical options for reconstructing residual limbs, which may in turn impact how well someone can interface with a robotic prosthesis later on. In this review, we aim to investigate what the literature has to say about different pathways for peripheral nerve regeneration and how each pathway can impact the neuromuscular tissue’s final electrophysiology. This information is important because it can guide us in planning the development of future bioelectronic devices, such as prosthetic limbs or neurostimulators. Future devices will primarily have to interface with tissue that has undergone some natural regeneration process, and so we have explored and reported here what is known about the bioelectrical features of neuromuscular tissue regeneration.

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Engineering the Spark Into Bioelectronic Medicine

Cited by 11 publications

References 25 publications

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Cut wires: The Electrophysiology of Regenerated Tissue

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