Abstract:The Burkholderia cepacia complex (Bcc) causes life-threatening respiratory tract infections in persons with cystic fibrosis (CF). In CF patients, end-stage pulmonary disease often requires lung transplantation. However, pre-transplant colonization with antibiotic-resistant strains of Burkholderia is predictive of poor post-transplant outcomes. To address this issue, phage therapy has been proposed as a treatment of multiple drug resistant bacterial infections. However, the majority of characterized Bcc phages … Show more
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