Nature Chem volume 9, issue 6, P537-545 2017 DOI: 10.1038/nchem.2713 View Full Text
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Jia Niu, David J. Lunn, Anusha Pusuluri, Justin I. Yoo, Michelle A. O'Malley, Samir Mitragotri, H. Tom Soh, Craig J. Hawker

Abstract: The capability to graft synthetic polymers onto the surfaces of live cells offers the potential to manipulate and control their phenotype and underlying cellular processes. Conventional grafting-to strategies for conjugating preformed polymers to cell surfaces are limited by low polymer grafting efficiency. Here we report an alternative grafting-from strategy for directly engineering the surfaces of live yeast and mammalian cells through cell surface-initiated controlled radical polymerization. By developing c…

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