Engineering InAsxP1-x/InP/ZnSe III−V Alloyed Core/Shell Quantum Dots for the Near-Infrared

Kim, Sang–Wook; Zimmer, John P.; Ohnishi, Shunsuke; Tracy, Joseph B.; Frangioni, John V.; Bawendi, Moungi G.

doi:10.1021/ja0434331

Cited by 228 publications

(172 citation statements)

References 19 publications

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“…Type II QDs are potential NIR emitters and growth of a second Type I shell (e.g., CdSe/CdTe/ ZnSe) 25 can enhance quantum yields; however, other Type I and alloyed NIRemitting QDs (e.g., InAs/ZnSe, InAs/ CdSe, InAs/InP, Cu:InP/ZnSe, InAs x P 1-x /InP/ZnSe) are also being actively developed. [26][27][28] Quasi Type II QDs have only a small offset between, for example, the conduction band edge states of the core and shell, such that the electron is delocalized over the whole nanocrystal but the hole is confined to the core (Fig. 2D).…”

Section: Optical Properties Of Quantum Dotsmentioning

confidence: 99%

Quantum Dots in Bioanalysis: A Review of Applications across Various Platforms for Fluorescence Spectroscopy and Imaging

2013

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Semiconductor quantum dots (QDs) are brightly luminescent nanoparticles that have found numerous applications in bioanalysis and bioimaging. In this review, we highlight recent developments in these areas in the context of specific methods for fluorescence spectroscopy and imaging. Following a primer on the structure, properties, and biofunctionalization of QDs, we describe select examples of how QDs have been used in combination with steady-state or time-resolved spectroscopic techniques to develop a variety of assays, bioprobes, and biosensors that function via changes in QD photoluminescence intensity, polarization, or lifetime. Some special attention is paid to the use of Förster resonance energy transfer-type methods in bioanalysis, including those based on bioluminescence and chemiluminescence. Direct chemiluminescence, electrochemiluminescence, and charge transfer quenching are similarly discussed. We further describe the combination of QDs and flow cytometry, including traditional cellular analyses and spectrally encoded barcode-based assay technologies, before turning our attention to enhanced fluorescence techniques based on photonic crystals or plasmon coupling. Finally, we survey the use of QDs across different platforms for biological fluorescence imaging, including epifluorescence, confocal, and twophoton excitation microscopy; single particle tracking and fluorescence correlation spectroscopy; super-resolution imaging; near-field scanning optical microscopy; and fluorescence lifetime imaging microscopy. In each of the above-mentioned platforms, QDs provide the brightness needed for highly sensitive detection, the photostability needed for tracking dynamic processes, or the multiplexing capacity needed to elucidate complex systems. There is a clear synergy between advances in QD materials and spectroscopy and imaging techniques, as both must be applied in concert to achieve their full potential.

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Section: Optical Properties Of Quantum Dotsmentioning

confidence: 99%

Quantum Dots in Bioanalysis: A Review of Applications across Various Platforms for Fluorescence Spectroscopy and Imaging

2013

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“…The major obstacles for the translation of QDs to clinical applications are inefficient delivery, potential toxicity, and lack of quantification (80). However, with the development of smaller (147,148), less toxic (149,150), and multifunctional (151,152) QDs and with further improvement of the conjugation strategy, QD-based probes may achieve optimal tumor-targeting efficacy with an acceptable toxicity profile for translation to clinical applications in the near future.…”

Section: Non-radionuclide-based Imaging Of Integrin a V B 3 Expressionmentioning

confidence: 99%

Multimodality Molecular Imaging of Tumor Angiogenesis

Cai

Chen²

2008

J Nucl Med

465

414

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Molecular imaging is a key component of 21st-century cancer management. The vascular endothelial growth factor (VEGF)/ VEGF receptor signaling pathway and integrin a v b 3 , a cell adhesion molecule, play pivotal roles in regulating tumor angiogenesis, the growth of new blood vessels. This review summarizes the current status of tumor angiogenesis imaging with SPECT, PET, molecular MRI, targeted ultrasound, and optical techniques. For integrin a v b 3 imaging, only nanoparticle-based probes, which truly target the tumor vasculature rather than tumor cells because of poor extravasation, are discussed. Once improvements in the in vivo stability, tumor-targeting efficacy, and pharmacokinetics of tumor angiogenesis imaging probes are made, translation to clinical applications will be critical for the maximum benefit of these novel agents. The future of tumor angiogenesis imaging lies in multimodality and nanoparticlebased approaches, imaging of protein-protein interactions, and quantitative molecular imaging. Combinations of multiple modalities can yield complementary information and offer synergistic advantages over any modality alone. Nanoparticles, possessing multifunctionality and enormous flexibility, can allow for the integration of therapeutic components, targeting ligands, and multimodality imaging labels into one entity, termed ''nanomedicine,'' for which the ideal target is tumor neovasculature. Quantitative imaging of tumor angiogenesis and protein-protein interactions that modulate angiogenesis will lead to more robust and effective monitoring of personalized molecular cancer therapy. Multidisciplinary approaches and cooperative efforts from many individuals, institutions, industries, and organizations are needed to quickly translate multimodality tumor angiogenesis imaging into multiple facets of cancer management. Not limited to cancer, these novel agents can also have broad applications for many other angiogenesis-related diseases.

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“…Also, an effort toward preparing alloyed Qdots, where the optical properties of the Qdots are tuned by composition rather than size or shape, and doped Qdots, where the Qdots have multiple properties, for example, optical and magnetic, are needed. [46][47][48][49] Qdots synthesized by these methods are nonpolar and insoluble in aqueous solvents, and therefore, they are not compatible with biological systems. Qdots are hydrophobic after synthesis because of the coordinating agent.…”

Section: Quantum-dot Synthesis and Surface Modification For Biomedicamentioning

confidence: 99%

Quantum Dots in Biological and Biomedical Research: Recent Progress and Present Challenges

2006

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The marriage of nanomaterials with biology has produced a new generation of technologies that can profoundly impact biological and biomedical research. Quantum dots (Qdots) are an archetype for this hybrid research area and have gained popularity and interest from diverse research communities because of their unique and tunable optical properties. In this Review, we will describe their history and development, optical and electronic properties, and applications in biology and medicine. A critical evaluation of barriers impacting current Qdot technologies will be discussed and insights into the future outlook of the field will be explored.

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Engineering InAs_xP_1-_x/InP/ZnSe III−V Alloyed Core/Shell Quantum Dots for the Near-Infrared

Cited by 228 publications

References 19 publications

Quantum Dots in Bioanalysis: A Review of Applications across Various Platforms for Fluorescence Spectroscopy and Imaging

Quantum Dots in Bioanalysis: A Review of Applications across Various Platforms for Fluorescence Spectroscopy and Imaging

Multimodality Molecular Imaging of Tumor Angiogenesis

Quantum Dots in Biological and Biomedical Research: Recent Progress and Present Challenges

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