Engineering gold nanoparticles for photothermal therapy, surgery, and imaging

Stabile, Jillian; Najafali, Daniel; Cheema, Yahya; Inglut, Collin T.; Liang, Barry J.; Vaja, Swapna; Sorrin, Aaron J.; Huang, Huang‐Chiao

doi:10.1016/b978-0-12-816662-8.00012-6

Cited by 14 publications

(10 citation statements)

References 131 publications

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“…PTT is a non-conventional cancer treatment strategy, safer and non-invasive than other techniques because of higher accuracy [95]. Gold nanoparticles are the most promising PTT agents as they have high adjustable properties such as, particle size, shape uniformity, and surface modification, which improve their treatment efficacy [96]. PEG is usually used to enhance the stability, solubility, and immune escape of these gold nanoparticles.…”

Section: Nanostars Coated With Rbc and Platelet Membrane For Drug Delivery In Skin Cancermentioning

confidence: 99%

Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

et al. 2021

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Cancer is one of the most common causes of death and affects millions of lives every year. In addition to non-infectious carcinogens, infectious agents contribute significantly to increased incidence of several cancers. Several therapeutic techniques have been used for the treatment of such cancers. Recently, nanotechnology has emerged to advance the diagnosis, imaging, and therapeutics of various cancer types. Nanomaterials have multiple advantages over other materials due to their small size and high surface area, which allow retention and controlled drug release to improve the anti-cancer property. Most cancer therapies have been known to damage healthy cells due to poor specificity, which can be avoided by using nanosized particles. Nanomaterials can be combined with various types of biomaterials to make it less toxic and improve its biocompatibility. Based on these properties, several nanomaterials have been developed which possess excellent anti-cancer efficacy potential and improved diagnosis. This review presents the latest update on novel nanomaterials used to improve the diagnostic and therapeutic of pathogen-associated and non-pathogenic cancers. We further highlighted mechanistic insights into their mode of action, improved features, and limitations.

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Section: Nanostars Coated With Rbc and Platelet Membrane For Drug Delivery In Skin Cancermentioning

confidence: 99%

Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

et al. 2021

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“…Moreover, the efficiency of gold-silica NPs might be increased by surface silanization with tumor cell ligands specific for each tumor entity, allowing a more specific approach toward different biomedical applications in oncology [19]. The combination of AuNPs-based photothermal therapy with other anticancer therapies, which allows the use of multiple mechanisms that target the growth and survival pathways of tumor cells, might represent a key for improving treatment outcomes in multiple fields of oncology [21].…”

Section: Aunps and Photothermal Therapy In Oncologymentioning

confidence: 99%

“…Lighting gold nanoparticles with IR laser radiation after their uptake by tumor cells represents a promising approach that might be utilized in clinical practice and, in particular, in oncology, both for diagnostic and therapeutic purposes [21,56,57]. With the development of gold nanoparticles designed for photothermal therapy applications and of miniaturized light-delivery systems, phototherapy will be able to access deep tumors located at anatomical sites in our body that are hard to reach with classical therapeutic approaches [21]. These data taken together, sustain the hypothesis that gold nanoparticle-mediated hyperthermia might represent a new era for photothermal therapy and, in particular, for anticancer therapy [22].…”

Section: Aunps As Photothermal Therapeutic Agentsmentioning

confidence: 99%

Gold Nanoparticles: A New Golden Era in Oncology?

et al. 2020

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In recent years, the spectrum of possible applications of gold in diagnostics and therapeutic approaches in clinical practice has changed significantly, becoming surprisingly broad. Nowadays, gold-based therapeutic agents are used in the therapy of multiple human diseases, ranging from degenerative to infectious diseases and, in particular, to cancer. At the basis of these performances of gold, there is the development of new gold-based nanoparticles, characterized by a promising risk/benefit ratio that favors their introduction in clinical trials. Gold nanoparticles appear as attractive elements in nanomedicine, a branch of modern clinical medicine, which combines high selectivity in targeting tumor cells and low toxicity. Thanks to these peculiar characteristics, gold nanoparticles appear as the starting point for the development of new gold-based therapeutic strategies in oncology. Here, the new gold-based therapeutic agents developed in recent years are described, with particular emphasis on the possible applications in clinical practice as anticancer agents, with the aim that their application will give rise to a new golden age in oncology and a breakthrough in the fight against cancer.

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“…Gold nanoparticles are generally easy to synthesize, biocompatible, and their unique surface plasmon resonance property allows efficient conversion of laser energy into heat (X. Huang et al, 2007;Stabile et al, 2020). Organic nanoparticles that are ideal for enhancing LITT include porphysomes, magnesium nanoparticles, and temperature sensitive liposomes loaded with gold nanoparticles (Ashikbayeva et al, 2020;H.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment

Pang

Kapur

Zhou

et al. 2022

WIREs Nanomed Nanobiotechnol

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Laser interstitial thermal therapy (LITT) guided by magnetic resonance imaging (MRI) is a new treatment option for patients with brain and non‐central nervous system (non‐CNS) tumors. MRI guidance allows for precise placement of optical fiber in the tumor, while MR thermometry provides real‐time monitoring and assessment of thermal doses during the procedure. Despite promising clinical results, LITT complications relating to brain tumor procedures, such as hemorrhage, edema, seizures, and thermal injury to nearby healthy tissues, remain a significant concern. To address these complications, nanoparticles offer unique prospects for precise interstitial hyperthermia applications that increase heat transport within the tumor while reducing thermal impacts on neighboring healthy tissues. Furthermore, nanoparticles permit the co‐delivery of therapeutic compounds that not only synergize with LITT, but can also improve overall effectiveness and safety. In addition, efficient heat‐generating nanoparticles with unique optical properties can enhance LITT treatments through improved real‐time imaging and thermal sensing. This review will focus on (1) types of inorganic and organic nanoparticles for LITT; (2) in vitro, in silico, and ex vivo studies that investigate nanoparticles' effect on light–tissue interactions; and (3) the role of nanoparticle formulations in advancing clinically relevant image‐guided technologies for LITT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Implantable Materials and Surgical Technologies > Nanoscale Tools and Techniques in Surgery

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Engineering gold nanoparticles for photothermal therapy, surgery, and imaging

Cited by 14 publications

References 131 publications

Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

Gold Nanoparticles: A New Golden Era in Oncology?

Nanoparticle‐assisted, image‐guided laser interstitial thermal therapy for cancer treatment

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