Biochemical Pharmacology volume 82, issue 10, P1438-1456 2011 DOI: 10.1016/j.bcp.2011.07.091 View full text
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Andy Chevigné, Virginie Fievez, Jean-Claude Schmit, Sabrina Deroo

Abstract: Chemokines are small chemoattractive proteins involved in many important physiological and pathological processes such as leukocyte mobilisation, inflammation, cancer and HIV-1 infection. The N-terminus of chemokines was shown to be crucial for interaction and activation with their cognate receptors. Therefore, multiple strategies including elongation, truncation, mutagenesis or chemical modifications of chemokine N-terminus were developed to identify analogues with modified selectivity displaying antagonist o…

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