2017
DOI: 10.1016/j.matbio.2016.06.001
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Abstract: Regeneration of traumatically injured skeletal muscles is severely limited. Moreover, the regenerative capacity of skeletal muscle declines with aging, further exacerbating the problem. Recent evidence support that delivery of muscle satellite cells to the injured muscles enhances muscle regeneration and reverses features of aging, including reduction in muscle mass and regenerative capacity. However, direct delivery of satellite cells presents a challenge at a translational level due to inflammation and donor… Show more

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Cited by 35 publications
(34 citation statements)
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References 138 publications
(170 reference statements)
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“…Lastly, the controlled pump delivery method for the biomimetic scaffold is simple, yet critical to the achievement of long-range alignment of the nanofibers (Materials and Methods). There are challenges in directly comparing our data with others due to differences in injected cell numbers, injury model, presence or absence of scaffold, the type of scaffold due to mode of gelation or cross-linking, and mode of injection (67). However, the biomimetic scaffolds described here constitute a broadly applicable stem cell delivery technology with the potential to substantially impact regenerative medicine.…”
Section: Discussionmentioning
confidence: 99%
“…Lastly, the controlled pump delivery method for the biomimetic scaffold is simple, yet critical to the achievement of long-range alignment of the nanofibers (Materials and Methods). There are challenges in directly comparing our data with others due to differences in injected cell numbers, injury model, presence or absence of scaffold, the type of scaffold due to mode of gelation or cross-linking, and mode of injection (67). However, the biomimetic scaffolds described here constitute a broadly applicable stem cell delivery technology with the potential to substantially impact regenerative medicine.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, total sulfated GAG amounts increase in the C2.7 myoblast cell line when myoblasts are differentiated to myotubes [15] indicating GAGs as important regulators of myogenesis – the process of muscle formation. Indeed, expression of various HSPGs is regulated during muscle regeneration and functionally involved in several signalling pathways such as FGF, HGF, Notch1 and Wnt7a [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]. Genetic ablation or modulation of HSPGs expressed in SCs, such as syndecan-3 and syndecan-4, dramatically affect muscle regeneration in response to injury and SC homeostasis [18], [20].…”
Section: Introductionmentioning
confidence: 99%
“…Hydrogel-based biomaterials offer a promising strategy to deliver therapeutics, including stem/progenitor cells and growth factors (13)(14)(15). These biomaterial systems enable precise control over the spatiotemporal release of therapeutic molecules and address clinical challenges associated with requiring high dosages, repeated administration, and short half-lives of protein-based agents (13).…”
Section: Introductionmentioning
confidence: 99%