Engineered human myogenic cells in hydrogels generate functional myofibers within dystrophic mouse muscle
Anna Kowala,
Jinhong Meng,
Olivier Pourquié
et al.
Abstract:Transplantation of human myogenic progenitor cells (MPCs) is a promising therapeutic strategy for treating muscle-wasting diseases, e.g., Duchenne muscular dystrophy (DMD). To increase engraftment efficiency of donor stem cells, modulation of host muscles is required, significantly limiting their clinical translation. Here we develop a clinically relevant transplantation strategy synergising hydrogel-mediated delivery and engineered human MPCs generated from CRISPR-corrected DMD patient-derived pluripotent ste… Show more
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