2013
DOI: 10.1161/circresaha.112.274241
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Abstract: Rationale A prothrombotic state and increased platelet reactivity are common in pathophysiological conditions associated with oxidative stress and infections. Such conditions are associated with an appearance of altered-self ligands in circulation that can be recognized by Toll-like receptors (TLR). Platelets express a number of TLR, including TLR9, however, the role of TLR in platelet function and thrombosis is poorly understood. Objective To investigate the biological activities of carboxy(alkylpyrrole) pr… Show more

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Cited by 139 publications
(174 citation statements)
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“…Moreover, TLR9 binds a carboxyalkylpyrrole protein adduct that may serve as a PAMP, resulting in platelet activation, aggregation, and granule secretion and thrombosis. 29 Though it is incompletely characterized, TLR9 may represent another functional platelet receptor linking immune, inflammatory, and thrombotic pathways.…”
Section: Platelets In Sepsismentioning
confidence: 99%
“…Moreover, TLR9 binds a carboxyalkylpyrrole protein adduct that may serve as a PAMP, resulting in platelet activation, aggregation, and granule secretion and thrombosis. 29 Though it is incompletely characterized, TLR9 may represent another functional platelet receptor linking immune, inflammatory, and thrombotic pathways.…”
Section: Platelets In Sepsismentioning
confidence: 99%
“…6 CAP proteins have been recently found in vivo and have gained significant attention because of their role in vascular endothelial growth factor receptor-independent angiogenesis, wound healing, and platelet activation. 7,8 CAP proteins were shown to induce cellular responses via Toll-like receptors (TLRs). Phosphatidylethanolamine (PE), the second most abundant phospholipid in mammalian membrane, possesses a primary amino group, and could be a target for modification by reactive aldehydes generated during lipid peroxidation.…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies have demonstrated that a number of endogenous ligands, such as altered selfligands, could also be recognized by TLRs [12][13][14] and contribute to progression of inflammation and atherosclerosis. As the role of platelet TLRs in response to pathological ligands in the circulation has started to emerge, 8,[14][15][16] whether endogenous ligands regulate thrombosis by engaging TLRs on platelets and the specific signaling pathways activation have not been known. In particular, the pathways connecting innate immunity and platelet integrin activation are not known.…”
Section: Introductionmentioning
confidence: 99%
“…From the point of view of statistical learning, predictive accuracy increases with higher model complexity, whereas the generalizability to future patients can be drastically reduced with high-dimensional data. 6 To what extent the reduction of FLIPI-2 factors is at the expense of lower predictive capacity remains to be determined. A fair comparison of PRIMA-PI and FLIPI-2 using the PRIMA cohort is not possible: PRIMA-PI is expected to be overfitted to its training cohort, whereas the evaluation of FLIPI-2 on the PRIMA cohort represents an independent validation (see figure).…”
mentioning
confidence: 99%
“…5 Furthermore, through interacting with TLR9 on platelets and TLR2 on macrophages, CEP was also identified as a prothrombotic and a proinflammatory factor, respectively. 6,7 In their article, Yakubenko et al report on the role of CEP in leukocyte trafficking during sterile inflammation. They showed in the inflamed peritoneal cavity of mice (after stimulation of the peritoneal cavity with thioglycollate over 72 hours) a strong upregulation of CEP expression compared with that in untreated tissue.…”
mentioning
confidence: 99%