Energy Metabolism and Ageing in the Mouse: A Mini-Review

Azzu, Vian; Valencak, Teresa G.

doi:10.1159/000454924

Cited by 78 publications

(60 citation statements)

References 62 publications

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“…Rodent models such as rats and mice are especially popular (they make up about 95% of animals used in research) because of several benefits: their ability to be easily reared under laboratory conditions, the proximity of their genome and physiology to that of humans, their short lifespan, and their pliability for genetic manipulation [23]. Thus, it is necessary to establish the fundamental properties of these models with regard to genetics, biology, and physiology in order to minimize spurious interpretations and ensure a level of accuracy and reliability adequate for experimental research.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies indicated that RMR differs depending on the strain, gender, weight gain, growth rate, and other conditions derived from genetic and circumstantial variables [2711]. Other studies approached the RMR-related analysis from the perspective of feeding, activity, and chemical substance administration, examining the effects of these variables within a strain as well as between strains [111213].…”

Section: Introductionmentioning

confidence: 99%

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Comparative analysis of basal locomotor activity-related metabolic phenotypes between C57BL/6 mice and ICR mice substrains derived from three different sources

et al. 2017

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Animal model, as an indispensable tool for scientific purposes of biomedical researches and clinical application, is a commonly used in various researches. Regarding to this, it is necessary to establish the metabolic phenotype of animal model to minimize spurious interpretations and ensure a level of accuracy and reliability adequate for experimental research. However, the metabolic phenotype-related analysis within rodent strains derived from different source is nonexistent, especially in C57BL/6Korl mice and Korl:ICR mice (a domestic mouse strain). To compare the physiological and metabolic phenotypes over a period of time, we utilized the C57BL/6 mice (C57BL/6Korl, A:C57BL/6, and B:C57BL/6) and ICR mice (Korl:ICR, A:ICR, and B:ICR) derived from three different sources. Our data showed that average body weight, body temperature, food intake, and water consumption have a similar tendency among the C57BL/6 and ICR groups, except for the higher body weight of C57BL/6Korl mice over a period of time. Moreover, some significant differences was observed in adipose tissue mass and adipocyte size among the groups, with a higher tendency of C57BL/6Korl mice and Korl:ICR mice. Most importantly, resting metabolic rate (RMR) serves as an approximation of the metabolic phenotype showed no significant difference among the groups of C57BL/6 mice and ICR mice, except for the lower oxygen uptake of C57BL/6Korl mice compare to the A:C57BL/6 mice. Taken together, our data suggest that C57BL/6 mice and ICR mice derived from three different sources have an overall similar feature of physiological and metabolic phenotypes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative analysis of basal locomotor activity-related metabolic phenotypes between C57BL/6 mice and ICR mice substrains derived from three different sources

et al. 2017

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“…For example, naked‐mole rats that live for 25–30 years have similar levels of energy metabolism as mice that live only 3–4 years . Birds have a metabolic rate up to twice as high as similarly‐sized mammals, yet they live on average about three times as long as body mass‐matched mammals . There is no inverse relationship between life span and mass‐specific metabolic rates in mice or fruit flies .…”

Section: Compatibility Of the Emta With Other Theories Of Agingmentioning

confidence: 99%

The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity

Chaudhari

Kipreos

2018

BioEssays

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Fused, elongated mitochondria are more efficient in generating ATP than fragmented mitochondria. In diverse C. elegans longevity pathways, increased levels of fused mitochondria are associated with lifespan extension. Blocking mitochondrial fusion in these animals abolishes their extended longevity. The long-lived C. elegans vhl-1 mutant is an exception that does not have increased fused mitochondria, and is not dependent on fusion for longevity. Loss of mammalian VHL upregulates alternate energy generating pathways. This suggests that mitochondrial fusion facilitates longevity in C. elegans by increasing energy metabolism. In diverse animals, ATP levels broadly decreases with age. Substantial evidence supports the theory that increasing or maintaining energy metabolism promotes the survival of older animals. Increased ATP levels in older animals allow energy-intensive repair and homeostatic mechanisms such as proteostasis that act to prevent cellular aging. These observations support the emerging paradigm that maintaining energy metabolism promotes the survival of older animals.

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“…Calorie intake and energy expenditure are the main components of energy homeostasis. Their integration is fundamental for the survival of living organisms, allowing them to adjust their physiological function to survive in extreme environmental conditions and contributing to their health and lifespan [1][2][3][4][5][6]. When energetic resources are limited, such as during controlled calorie restriction (CR), endotherms limit energy expenditure by lowering core body temperature (T b ) [7,8].…”

Section: Introductionmentioning

confidence: 99%

Gonadal hormones influence core body temperature during calorie restriction

et al. 2019

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During calorie restriction (CR), endotherms adjust several physiological processes including the decrease of core body temperature (T b ) and reduction of energy expenditure. We recently found that CR-induced hypothermia is regulated in a sex-dependent manner in mice with lowered central insulin-like growth factor receptor signaling. Here, we describe the contribution of sex hormones to CR-induced hypothermia in wild type C57BL6 mice by measuring T b of female and male mice following bilateral gonadectomy and hormonal replacement. Specifically, we evaluated the effects of progesterone (P4), 17-ß estradiol (E2), a combination of both (P4 + E2) in females and of 5-α dihydrotestosterone (5-α DHT) in males. Gonadectomy resulted in an earlier and stronger CR-induced hypothermia in both sexes. These effects were fully antagonized in females by E2 replacement, but not by P4, which had only minor and partial effects when used alone and did not prevent the action of E2 during CR when both hormones were given in combination. 5-α-DHT had only minor and transient effects on preventing the reduction of T b during CR on gonadectomized male mice. These findings indicate that gonadal hormones contribute to sex-specific regulation of T b and energy expenditure when nutrient availability is scarce.

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Energy Metabolism and Ageing in the Mouse: A Mini-Review

Cited by 78 publications

References 62 publications

Comparative analysis of basal locomotor activity-related metabolic phenotypes between C57BL/6 mice and ICR mice substrains derived from three different sources

Comparative analysis of basal locomotor activity-related metabolic phenotypes between C57BL/6 mice and ICR mice substrains derived from three different sources

The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity

Gonadal hormones influence core body temperature during calorie restriction

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