Energy balance and the sphingosine-1-phosphate/ceramide axis

Green, Cara L; Mitchell, Sharon; Speakman, John R.

doi:10.18632/aging.101347

Cited by 7 publications

(13 citation statements)

References 7 publications

(13 reference statements)

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“…S1P is an example of a lipid that binds to its GPCR receptors S1PR 1-5 with high affinity [134]. S1P levels decrease during aging and increase upon exercise and DR [22]. It will be interesting to determine how S1 PR signaling influence aging and whether this involves remodeling of the epigenomic landscape.…”

Section: Lipid-induced Signaling Pathways Indirectly Impact Chromatinmentioning

confidence: 99%

“…In addition, several plasma sphingolipids and their metabolites are also increased in long-lived naked mole-rats compared to wild type mice [21]. Sphingolipids can be converted into sphingosine-1-phosphate (S1P) and ceramides, two bioactive lipids with opposing biological effects ( Figure 1) [22]. Whereas S1P promotes cell proliferation and survival, ceramides promote apoptosis [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…Sphingolipids can be converted into sphingosine-1-phosphate (S1P) and ceramides, two bioactive lipids with opposing biological effects ( Figure 1) [22]. Whereas S1P promotes cell proliferation and survival, ceramides promote apoptosis [22][23][24]. The balance between S1P and ceramides, termed the S1P/ceramide axis, modulates the aging process [22].…”

Section: Introductionmentioning

confidence: 99%

“…Whereas S1P promotes cell proliferation and survival, ceramides promote apoptosis [22][23][24]. The balance between S1P and ceramides, termed the S1P/ceramide axis, modulates the aging process [22]. Age-related diseases, including Alzheimer's disease and diabetes, are associated with low levels of S1P [25,26].…”

Section: Introductionmentioning

confidence: 99%

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Linking Lipid Metabolism to Chromatin Regulation in Aging

Papsdorf

Brunet

2019

Trends in Cell Biology

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The lifespan of an organism is strongly influenced by environmental factors, including diet, and by internal factors, notably reproductive status. Lipid metabolism is critical for adaptation to external conditions or reproduction. Interestingly, specific lipid profiles are associated with longevity and increased uptake of certain lipids extends longevity in C. elegans and ameliorates disease phenotypes in humans. How lipids impact longevity, and how lipid metabolism is regulated during aging, is just beginning to be unraveled. This review describes recent advances in the regulation and role of lipids in longevity, focusing on the interaction between lipid metabolism and chromatin states in aging and age-related diseases.

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Section: Lipid-induced Signaling Pathways Indirectly Impact Chromatinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Linking Lipid Metabolism to Chromatin Regulation in Aging

Papsdorf

Brunet

2019

Trends in Cell Biology

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“…IIS, a highly inter-connected metabolic regulatory system, is implicated in stress resistance/aging modulation throughout the spectrum of organisms from nematodes to vertebrates [ 122 , 123 ]. Interestingly, many roles of S1P appear to be largely analogous to those of IIS, including not only the well-documented cell survival/death signaling but also the engagement in organism’s energy homoeostasis [ 124 ].…”

Section: Bioactive Sphingolipids In Agingmentioning

confidence: 99%

The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration

et al. 2018

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Bioactive sphingolipids: sphingosine, sphingosine-1-phosphate (S1P), ceramide, and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation, differentiation, and in multiple aspects of stress response in the nervous system. The opposite roles of closely related sphingolipid species in cell survival/death signaling is reflected in the concept of tightly controlled sphingolipid rheostat. Aging has a complex influence on sphingolipid metabolism, disturbing signaling pathways and the properties of lipid membranes. A metabolic signature of stress resistance-associated sphingolipids correlates with longevity in humans. Moreover, accumulating evidence suggests extensive links between sphingolipid signaling and the insulin-like growth factor I (IGF-I)-Akt-mTOR pathway (IIS), which is involved in the modulation of aging process and longevity. IIS integrates a wide array of metabolic signals, cross-talks with p53, nuclear factor κB (NF-κB), or reactive oxygen species (ROS) and influences gene expression to shape the cellular metabolic profile and stress resistance. The multiple connections between sphingolipids and IIS signaling suggest possible engagement of these compounds in the aging process itself, which creates a vulnerable background for the majority of neurodegenerative disorders.

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Energy balance and the sphingosine-1-phosphate/ceramide axis

Cited by 7 publications

References 7 publications

Linking Lipid Metabolism to Chromatin Regulation in Aging

Linking Lipid Metabolism to Chromatin Regulation in Aging

The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration

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