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Cited by 7 publications
(9 citation statements)
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References 7 publications
(9 reference statements)
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“…S1P is an example of a lipid that binds to its GPCR receptors S1PR 1-5 with high affinity [134]. S1P levels decrease during aging and increase upon exercise and DR [22]. It will be interesting to determine how S1 PR signaling influence aging and whether this involves remodeling of the epigenomic landscape.…”
Section: Lipid-induced Signaling Pathways Indirectly Impact Chromatinmentioning
confidence: 99%
See 3 more Smart Citations
“…S1P is an example of a lipid that binds to its GPCR receptors S1PR 1-5 with high affinity [134]. S1P levels decrease during aging and increase upon exercise and DR [22]. It will be interesting to determine how S1 PR signaling influence aging and whether this involves remodeling of the epigenomic landscape.…”
Section: Lipid-induced Signaling Pathways Indirectly Impact Chromatinmentioning
confidence: 99%
“…In addition, several plasma sphingolipids and their metabolites are also increased in long-lived naked mole-rats compared to wild type mice [21]. Sphingolipids can be converted into sphingosine-1-phosphate (S1P) and ceramides, two bioactive lipids with opposing biological effects ( Figure 1) [22]. Whereas S1P promotes cell proliferation and survival, ceramides promote apoptosis [22][23][24].…”
Section: Introductionmentioning
confidence: 99%
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“…IIS, a highly inter-connected metabolic regulatory system, is implicated in stress resistance/aging modulation throughout the spectrum of organisms from nematodes to vertebrates [ 122 , 123 ]. Interestingly, many roles of S1P appear to be largely analogous to those of IIS, including not only the well-documented cell survival/death signaling but also the engagement in organism’s energy homoeostasis [ 124 ].…”
Section: Bioactive Sphingolipids In Agingmentioning
confidence: 99%