Endovascular Electrical Stimulation—A Novel Hemorrhage Control Technique

Kezurer, Noa; Heldenberg, Eitan; Farah, Nairouz; Ivzan, Nadav; Mandel, Yossi

doi:10.1109/tbme.2018.2883212

Cited by 4 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The modulation of stellate/cervical ganglion has the potential to relay to abdominal ganglia and modulate abdominal arteries' blood ow. It has been demonstrated that moderately high intensity of direct arterial electrical stimulation is capable of suppressing the blood ow and contract the arteries [10][11][12]. With this in mind, a fourth potential mechanism of a direct effect of non-invasive electrical stimulation on abdominal arteries can be not excluded in the context of the high intensity (35mA) of the present stimulation that has been utilised in the present study.…”

Section: Mechanism Of Actionmentioning

confidence: 88%

“…Invasive electrical stimulation studies have also used the same target (smooth muscles of the noncompressible organ's arteries) to decrease the internal organs' blood ow [10][11][12]. Invasive electrical stimulation of arteries, or in other words, directly stimulating the arteries by placing the electrodes on these arteries demonstrated that 10Hz electrical stimulation is capable of constricting the arteries in animal models [11], however, the intensity of electrical stimulation in these studies was too high as 150V is not applicable for non-invasive approaches.…”

Section: Introductionmentioning

confidence: 99%

“…Invasive electrical stimulation of arteries, or in other words, directly stimulating the arteries by placing the electrodes on these arteries demonstrated that 10Hz electrical stimulation is capable of constricting the arteries in animal models [11], however, the intensity of electrical stimulation in these studies was too high as 150V is not applicable for non-invasive approaches. In this context, frequency-speci c effects are confounded by the high intensities and the authors also demonstrated that low versus high voltage effects may have varying mechanisms of action in animals [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

Çakmak¹,

Khwaounjoo

Pangilinan

et al. 2022

Preprint

View full text Add to dashboard Cite

Non-invasive neuromodulation of non-compressible internal organs has significant potential for internal organ bleeding and blood-shift in aero/space medicine. The present study aims to investigate the potential influences of the non-invasive transcutaneous electrical nerve stimulation (TENS) on multiple non-compressible internal organs’ blood flow. Porcine animal model (n = 8) was randomized for a total of 48 neuromodulation sessions with two different TENS stimulation frequencies (80Hz, 10Hz) and a placebo stimulation. A combination of two different electrode configurations (Abdominal or Abdominal and Hind Limb) were also performed. Intraarterial blood flow measurements were taken during pre and post-stimulation periods at the left renal artery, common hepatic artery, and left coronary artery. Intracranial, and extracranial arterial blood flows were also assessed with digital subtraction angiography. TENS with abdominal-only electrode configurations at 10hz demonstrated significant reductions in average peak blood flow velocity (APV) of the common hepatic artery (p = 0.0233) and renal arteries (p = 0.0493). Arterial pressures (p = 0.0221) were also significantly lower when renal APV was reduced. The outcome of the present study emphasises the potential use of TENS in decreasing the blood flow of non-compressible internal organs when the correct combination of electrodes configuration and frequency is used.

show abstract

Section: Mechanism Of Actionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

Çakmak¹,

Khwaounjoo

Pangilinan

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Identification of blood loss based on multiple physiological parameters

Chen,

He,

Liu

et al. 2024

Biomedical Signal Processing and Control

View full text Add to dashboard Cite

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

Cakmak,

Khwaounjoo,

Pangilinan

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Non-invasive neuromodulation of non-compressible internal organs has significant potential for internal organ bleeding and blood-shift in aero/space medicine. The present study aims to investigate the potential influences of the non-invasive transcutaneous electrical nerve stimulation (TENS) on multiple non-compressible internal organs’ blood flow. Porcine animal model (n = 8) was randomized for a total of 48 neuromodulation sessions with two different TENS stimulation frequencies (80 Hz, 10 Hz) and a placebo stimulation. A combination of two different electrode configurations (Abdominal-only or Abdominal and hind limb) were also performed. Intraarterial blood flow measurements were taken during pre and post-stimulation periods at the left renal artery, common hepatic artery, and left coronary artery. Intracranial, and extracranial arterial blood flows were also assessed with digital subtraction angiography. TENS with abdominal-only electrode configurations at 10 Hz demonstrated significant reductions in average peak blood flow velocity (APV) of the common hepatic artery (p = 0.0233) and renal arteries (p = 0.0493). Arterial pressures (p = 0.0221) were also significantly lower when renal APV was reduced. The outcome of the present study emphasises the potential use of TENS in decreasing the blood flow of non-compressible internal organs when the correct combination of electrodes configuration and frequency is used.

show abstract

Endovascular Electrical Stimulation—A Novel Hemorrhage Control Technique

Cited by 4 publications

References 26 publications

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

Identification of blood loss based on multiple physiological parameters

Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation

Contact Info

Product

Resources

About