Endothelin-1 May Be a Potential Biomarker for Monitoring Changes in Nitric Oxide Metabolism in Pulmonary Hypertension

Yunis, Adil; Nouraie, Mehdi; Britton, Noel; Zhang, Yingze; Helbling, Nicole L.; Warr, H.; Shiva, Shruti; Morris, Alison; Simon, Marc A.

doi:10.1016/j.cardfail.2020.09.057

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genotype AG of the rs12483377 SNP had significantly lower serum levels of endostatin compared with the homozygous GG genotype ( 27 ). Another example is the use of plasma endothelin-1 as an effective biomarker for monitoring and predicting the outcome of pulmonary hypertension ( 28 , 29 ). In another study, the presence of the rs2070699 T allele of the EDN1 gene that encodes endothelin-1 was associated with higher plasma endothelin-1 levels, which increase the risk of PPHN in neonates with respiratory distress ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Length of hospital stay (days)22(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) In-hospital mortality2 (3.7) Data are presented as mean ± standard deviation, median (interquartile range), or n (%). PPHN, persistent pulmonary hypertension of the newborn.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Genome-wide association study identifies WWC2 as a possible locus associated with persistent pulmonary hypertension of the newborn in the Thai population

Nakwan¹,

Kunhapan²,

Chaiyasung³

et al. 2023

Transl Pediatr

View full text Add to dashboard Cite

Background There is known to be significant genetic involvement in persistent pulmonary hypertension of the newborn (PPHN), but to date there is not a clear understanding of this situation, and clarifying that involvement would be of considerable assistance in devising effective treatments for the disease. This case-control study was undertaken to search for genetic variants associated with PPHN in the Thai population using a genome-wide association study (GWAS). Methods A 659,184 single nucleotide polymorphisms from 387 participants (54 PPHN cases and 333 healthy participants) were genotyped across the human genome using an Illumina Asian Screening Array-24 v1.0 BeadChip Array. After quality control, we obtained 443,063 autosomal SNPs for the GWAS analysis. The FaST-LMM and R packages were used for all statistical analyses. Results For the case-control analysis, the genomic inflation factor (λ) was 1.016, rs149768622 T>C in the first intron of WWC2 gene showed the strongest association with a P value of 3.76E-08 and odds ratio (OR) of 13.24 (95% CI: 3.91–44.78). The variants at the LOC102723906 / LOC105377599 , CADM4 , GPM6A , CIT , RIMBP2 , LOC105374510 , LOC105375193 , PTPRN2 , CDK14 , and LCORL loci showed suggestive evidence of associations with PPHN (P<1E-05). Conclusions This GWAS found that rs149768622 T>C in the WWC2 gene was possibly associated with PPHN. However, replication and functional studies are needed to validate this association and further explore the role(s) of the WWC2 gene in PPHN.

show abstract