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Cited by 127 publications
(223 citation statements)
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“…6H). In this assay, Ang2 stimulated cell motility on gelatin, which is recognized by avb3 rather than a2b1 integrins in HUVECs (Rüegg et al, 1998;Starke et al, 2011). Collectively, the data suggested that Ang2-specific Tie2 translocation and inhibition of cell motility occurs early after Ang2 stimulation, and that VEGF and the ECM environment also modulate Ang2-induced functions.…”
Section: Substrate-bound Ang2 Mediates Weak Cell Adhesion and Spreadingmentioning
confidence: 88%
“…6H). In this assay, Ang2 stimulated cell motility on gelatin, which is recognized by avb3 rather than a2b1 integrins in HUVECs (Rüegg et al, 1998;Starke et al, 2011). Collectively, the data suggested that Ang2-specific Tie2 translocation and inhibition of cell motility occurs early after Ang2 stimulation, and that VEGF and the ECM environment also modulate Ang2-induced functions.…”
Section: Substrate-bound Ang2 Mediates Weak Cell Adhesion and Spreadingmentioning
confidence: 88%
“…Low vWF activity perhaps indicates ongoing endothelial perturbation in patients with more severe PAH, portending worse survival. vWF has also been shown to be a potent angiogenesis inhibitor (46). It is possible that in the presence of low vWF activity there is increased angiogenesis leading to a more aggressive PAH phenotype and worse survival.…”
Section: Original Researchmentioning
confidence: 99%
“…Therefore, it is quite possible that other pathways leading to Ang-2 gene expression could be involved. Most interesting is the novel observation that in vitro loss of vWF can induce Ang-2 release from EC resulting in sprouting angiogenesis (23). Whether a selective decrease of the HMWMs of vWF as seen in CF LVAD subjects can cause a similar effect is unknown and warrants investigation.…”
Section: Mechanism Of Ang-2 Productionmentioning
confidence: 99%