Endothelial nitric oxide synthase activation contributes to post-exercise hypotension in spontaneously hypertensive rats

Lee, Sang Ki; Kim, Cuk-Seong; Kim, Hyo Shin; Cho, Eun Jung; Joo, Hee Kyoung; Lee, Ji Young; Lee, Eun Ji; Park, Jin Bong; Jeon, Byeong Hwa

doi:10.1016/j.bbrc.2009.03.090

Cited by 16 publications

(17 citation statements)

References 20 publications

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“…However, there are other mechanisms which also contribute to postexercise hypotension. It has been shown that nitric oxide synthase activity in the endothelium and the rennin angiotensin system are activated during exercise [Lee et al 2009;Wan et al 2007]. Blockade of angiotensin II receptor has been shown to increase the effect of exercise to limit cardiac postinfarct ventricular remodeling in rats [Xu et al 2008].…”

Section: Discussionmentioning

confidence: 99%

“…Although the mechanism of cardiovascular protection induced by exercise is not fully understood, the BP lowering effect post exercise is believed to be a major contributor [Collins et al 2001;MacDonald, 2002;Pescatello et al 2004;Halliwill et al 2012]. The effect could be mediated via changes in neurohormonal release, oxidant/antioxidant balance, and synthesis of molecular mediators [Di Francescomarino et al 2009;Kavazis, 2009;Terziotti et al 2001], improve glucose uptake by a noninsulin-dependent mechanism [Lee-Young et al 2010] and correcting the imbalance occurring in endothelial dysfunction [Hirata et al 2010;Lizardo et al 2008;Lee et al 2009]. It is possible many or all of these factors are contributing to the cardiovascular health benefits from exercise.…”

Section: Introductionmentioning

confidence: 99%

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Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats

Yeung

Dauphinee

Marcoux

2013

Therapeutic Advances in Cardiovascular Disease

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats

Yeung

Dauphinee

Marcoux

2013

Therapeutic Advances in Cardiovascular Disease

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“…However, the precise prescription of exercise should be taken into consideration, especially regarding the intensity of exercise. Considering that one of the benefits of exercise for hypertensive subjects is the PEH effect [3,18], and since exercise intensity seems to influence the magnitude of the PEH effect [19,20] it is particularly important to establish the appropriate intensity at which the exercise is carried out, With this in mind, Lee et al [21] showed a PEH in SHR (15 m.min -1 for 20 min), and there are several other studies that showed substantial benefits of exercise in SHR model [22-24]. Furthermore, it has been observed that hypertensive myocardium improved after 12 weeks of running (60 min, 5 days/week) at the velocity of 20–25 m.min -1 [6], which corresponds to exercise performed both above and at the MLSS intensity determined by this study.…”

Section: Discussionmentioning

confidence: 99%

Assessment of maximal lactate steady state during treadmill exercise in SHR

Almeida¹,

Petriz²,

Gomes³

et al. 2012

BMC Res Notes

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BackgroundSpontaneously hypertensive rats (SHR) are one of the main animal models used for studying the effects of exercise on hypertension. Therefore, the determination of adequate intensity has been essential for secure and optimized exercise prescriptions concerning hypertensive subjects. This study aimed to identify the MLSS in SHR by using a treadmill test to improve the protocols and further prescriptions of exercise intensity.FindingsIn order to carry out this determination, SHR (n = 10) animals (~17.5 weeks; 227.4 ± 29.3 g; 172.4 ± 8.1 mmHg systolic blood pressure) were divided into two groups (G1 n = 5; G2 n = 5). Rats underwent a test with three different velocities to determine the MLSS. The MLSS was considered as the highest effort intensity where the blood lactate did not vary more than 1 mmol.L-1 from the 10th to the 25th minute. The MLSS was reached at a velocity of 20 m.min-1 with 3.8 ± 0.5 mmol.L-1 of lactate for G1. Additionally, the results were validated in G2. However, when the test was applied at 25 m.min-1, there was no stabilization of BLC in G1 and G2.ConclusionsIn this study it was possible to identify the MLSS in SHR rats, which is an excellent evaluation tool to control exercise intensity. These data are of considerable importance in studies using physical exercise as a means of research in hypertension and may lead to the intensity of exercise being prescribed more appropriately.

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“…Exercise activates nitric oxide synthase activity in the endothelium and the renin angiotensin system [41, 42]. Blockade of angiotensin II receptor has been shown also to augment the effect of exercise in reducing post-myocardial infarct ventricular remodeling in rats [43].…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study to Assess Adenosine 5’-triphosphate Metabolism in Red Blood Cells as a Drug Target for Potential Cardiovascular Protection

Yeung

Tinkel²,

Seeto³

2016

CHDDT

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Objective: To study the effect of exercise preconditioning on adenosine 5’triphosphate (ATP) metabolism in red blood cells and cardiovascular protection against injury induced by isoproterenol in vivo. Methods: Male Sprague Dawley rats (SDR) were each exercised on a treadmill for 15 minutes at 10 m/min and 10% grade (n = 7) (LowEx), or 14 m/min and 22% grade (n = 8) (VigEx). Two hours after the exercise, each rat received a single dose of isoproterenol (30 mg/kg) by subcutaneous (sc) injection. Two separate groups of SDR were used as control: One received no exercise (n = 10) (NoEx) and the other received no exercise and no isoproterenol (n = 11) (NoIso). Serial blood samples were collected over 5 hours for measurement of ATP and its catabolites by a validated HPLC. Hemodynamic recording was collected continuously for  the duration of the experiment. Data were analysed using ANOVA and t-tests and difference considered significant at  p < 0.05. Results: Exercise pre-conditioning (both LowEx and VigEx) reduced mortality after isoproterenol from 50% to < 30%  (p > 0.05). It attenuated the rebound in blood pressure significantly (p < 0.05 between NoEx vs VigEx), attenuated the increase of RBC adenosine 5’-monophosphate (AMP) concentrations induced by isoproterenol, and also decreased the breakdown of ATP to AMP in the RBC (p < 0.05 vs NoEx). Conclusion: Exercise pre-conditioning decreased the blood pressure rebound and also breakdown of ATP in RBC after isoproterenol which may be exploited further as a drug target for cardiovascular protection and prevention.

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Endothelial nitric oxide synthase activation contributes to post-exercise hypotension in spontaneously hypertensive rats

Cited by 16 publications

References 20 publications

Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats

Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats

Assessment of maximal lactate steady state during treadmill exercise in SHR

A Pilot Study to Assess Adenosine 5’-triphosphate Metabolism in Red Blood Cells as a Drug Target for Potential Cardiovascular Protection

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