2000
DOI: 10.1016/s1010-7940(00)00549-2
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Abstract: Objectives: Minimally invasive saphenous harvesting techniques have been shown to reduce post-operative morbidity. However, when applying new techniques of vein harvesting, endothelial integrity should be preserved in order to guarantee graft quality. We investigated the impact of two different minimally invasive saphenous vein harvesting techniques on endothelial function compared with the traditional open' technique by inducing endothelium-dependent in vitro relaxation. Methods: Two different minimally invas… Show more

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Cited by 8 publications
(6 citation statements)
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“…Conduit harvesting is known to damage the endothelium and may reduce endothelial nitric oxide synthase and nitric oxide release 24,25 ; however, careful surgical technique may minimize endothelial damage of coronary conduits. 26,27 Shear stress is also known to affect graft endothelial function, and reducing shear stress during graft preparation may preserve endothelial integrity. 24,28 Details of the harvesting techniques used in the RSVP trial have been published previously.…”
Section: Discussionmentioning
confidence: 99%
“…Conduit harvesting is known to damage the endothelium and may reduce endothelial nitric oxide synthase and nitric oxide release 24,25 ; however, careful surgical technique may minimize endothelial damage of coronary conduits. 26,27 Shear stress is also known to affect graft endothelial function, and reducing shear stress during graft preparation may preserve endothelial integrity. 24,28 Details of the harvesting techniques used in the RSVP trial have been published previously.…”
Section: Discussionmentioning
confidence: 99%
“…It also acts by inhibiting the calcium intake to the cell and the secretion of calcium that is stored in the cytosol [19]. Thanks to this characteristic, it has been argued that it caused vasodilatation at a sufficient level in arterial grafts; and it is still used for this purpose in our present time [20]. The most important problem about the local use of papaverine is that it has a strong acidic structure.…”
Section: Discussionmentioning
confidence: 99%
“…In discussing MIS harvesting of the GSV, it is important to first recognize that there are many methods claiming to be minimally invasive. Those methods that should be considered minimally invasive include harvesting through multiple small incisions with the aid of a Mayo stripper, 2 com- pletely endoscopic SV harvesting, 9,10 and harvesting of the vein with the aid of various lighted retractors. 1,9 These 3 methods are important in that they have been proved to preserve the endothelium on the basis of formal in vitro testing of relaxation in response to ACh.…”
Section: Discussionmentioning
confidence: 99%
“…11 ACh, which stimulates the release of nitric oxide (NO), is the mediator of choice to test SV endothelial cell function. 2,9 After a precontraction of the GSV ring with PE, ACh normally stimulates a decrease in tension or vasodilation. In the absence of normal endothelial function, there is no vasodilation; in fact, one might observe paradoxical vasoconstriction.…”
Section: Experimental Protocolmentioning
confidence: 99%
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