Endothelial dysfunction, intima–media thickness and coronary reserve in relation to risk factors and Framingham score in patients without clinical atherosclerosis

Abstract

In patients without clinical atherosclerotic disease, cardiovascular risk factors are associated with impaired FMD, CFR and increased IMT. Even though a correlation between these changes was found, they showed different dependence on cardiovascular risk factors and with global risk, IMT being the best correlated with the Framingham score.

Intra-renal hemodynamics and carotid intima-media thickness in the metabolic syndrome

“…To the best of our knowledge, our results confirm the association between intra-renal hemodynamic indices and carotid IMT in nonpharmacologically treated subjects with MetS without renal disease, suggesting that increased intra-renal resistances reflect a systemic vascular impairment. Since an increased carotid IMT is known to be associated with impaired endothelial function [34], our results may also lend credence to the hypothesis that endothelial dysfunction may have vasoconstrictor effects [11] and therefore induce elevated intra-renal RI and PI. To the best of our knowledge, there is no data examining the discriminatory differences between intra-renal PI and RI compared to carotid IMT.…”

Occupational stress and subclinical atherosclerosis: a systematic review

“…20 This has been found to linearly increase the Framingham risk score for cardiovascular disease. 21 Carotid artery intima media thickness is high among people who have symptomatic coronary artery disease compared to asymptomatic controls. A thickening of the CIMT of more than 1 mm has been associated with a 5.07 (95% CI 3.08-8.36) relative risk (compared to those with #1 mm) for coronary artery disease in women and 1.85 (95% CI 1.28-2.69) in men, based on data from the Atherosclerosis Risk in Communities study.…”

The relation of intima-media thickness with endothelial function and left ventricular mass index

“…'larının (12) koroner risk faktörü taşımayan sağlıklı olgularda yaptığı çalışmada karotis İMK'sının, Brakiyal arter FMD ve koroner akım rezervi ile iyi korele olduğu belirtilmiştir. Birkaç çalışma karotis İMK'sı ile FMD arasında korelasyon olmadığını belirtse de (13), çok sayıda çalış-ma karotis İMK'sının FMD ile iyi korele olduğunu göstermiştir (14)(15)(16). Bunun yanında karotis İMK'sı ile ilgili çalışmalarda ana karotis ve dallarının ayrı ayrı değerlendirilmesi konusu bir sıkıntı oluşturmaktadır.…”