Endothelial dysfunction and C‐reactive protein predict the incidence of heart failure in hypertensive patients

Maio, Raffaele; Perticone, Maria; Suraci, Edoardo; Sciacqua, Angela; Sesti, Giorgio; Perticone, Francesco

doi:10.1002/ehf2.13088

Cited by 22 publications

(25 citation statements)

References 35 publications

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“…hsCRP levels have been reported as independent prognostic determinants in NIDCM and generally increase as HF progresses. 3,[23][24][25] Myocardial fibrosis is also a prognostic determinant. 5,6 However, hsCRP and CVF were not significant determinants in our results.…”

Section: Discussionmentioning

confidence: 99%

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Serum autotaxin as a novel prognostic marker in patients with non‐ischaemic dilated cardiomyopathy

et al. 2022

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Aims Autotaxin (ATX) promotes myocardial inflammation, fibrosis, and the subsequent cardiac remodelling through lysophosphatidic acid production. However, the prognostic impact of serum ATX in non-ischaemic dilated cardiomyopathy (NIDCM) has not been clarified. We investigated the prognostic impact of serum ATX in patients with NIDCM. Methods and resultsWe enrolled 104 patients with NIDCM (49.8 ± 13.4 years, 76 men). We divided the patients into two groups using different cutoffs of median serum ATX levels for men and women: high-ATX group and low-ATX group. Cardiac events were defined as a composite of cardiac death and heart failure resulting in hospitalization. Median ATX level was 203.5 ng/mL for men and 257.0 ng/mL for women. Brain natriuretic peptide levels [224.0 (59.6-689.5) pg/mL vs. 96.5 (40.8-191.5) pg/mL, P = 0.010] were higher in the high-ATX group than low-ATX group, whereas high-sensitivity C-reactive protein and collagen volume fraction levels in endomyocardial biopsy samples were not significantly different between the two groups. Kaplan-Meier survival analysis revealed that the event-free survival rate was significantly lower in the high-ATX group than low-ATX group (log-rank; P = 0.007). Cox proportional hazard analysis revealed that high-ATX was an independent determinant of composite cardiac events. In both sexes, serum ATX levels did not correlate with high-sensitivity C-reactive protein levels and collagen volume fraction but had a weak correlation with brain natriuretic peptide levels (men; spearman's rank: 0.274, P = 0.017, women; spearman's rank: 0.378, P = 0.048). Conclusion High serum ATX levels can be associated with increasing adverse clinical outcomes in patients with NIDCM. These results indicate serum ATX may be a novel biomarker or therapeutic target in NIDCM.

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Section: Discussionmentioning

confidence: 99%

“…15,28,29 The relationship between vascular endothelial function and HF has also been reported. 23,30 Elevated ATX might also increase the levels of other inflammatory substances, which might have affected the prognosis.…”

Section: Discussionmentioning

confidence: 99%

Serum autotaxin as a novel prognostic marker in patients with non‐ischaemic dilated cardiomyopathy

et al. 2022

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“…NPTX2 encodes a synaptic protein associated with C-reactive protein. Several studies have confirmed that C-reactive protein can effectively predict the occurrence of HF ( Maio et al, 2021 ). Deletion or mutation of BLM may result in telomere defects and accelerated telomere shortening ( Callén and Surrallés, 2004 ).…”

Section: Discussionmentioning

confidence: 98%

Integration of RNA molecules data with prior-knowledge driven Joint Deep Semi-Negative Matrix Factorization for heart failure study

Chen

Zhang

et al. 2022

Front. Genet.

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Heart failure (HF) is the main manifestation of cardiovascular disease. Recent studies have shown that various RNA molecules and their complex connections play an essential role in HF’s pathogenesis and pathological progression. This paper aims to mine key RNA molecules associated with HF. We proposed a Prior-knowledge Driven Joint Deep Semi-Negative Matrix Factorization (PD-JDSNMF) model that uses a hierarchical nonlinear feature extraction method that integrates three types of data: mRNA, lncRNA, and miRNA. The PPI information is added to the model as prior knowledge, and the Laplacian constraint is used to help the model resist the noise in the genetic data. We used the PD-JDSNMF algorithm to identify significant co-expression modules. The elements in the module are then subjected to bioinformatics analysis and algorithm performance analysis. The results show that the PD-JDSNMF algorithm can robustly select biomarkers associated with HF. Finally, we built a heart failure diagnostic model based on multiple classifiers and using the Top 13 genes in the significant module, the AUC of the internal test set was up to 0.8714, and the AUC of the external validation set was up to 0.8329, which further confirmed the effectiveness of the PD-JDSNMF algorithm.

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“…Additionally, hs-CRP is a marker of senescence and aging, which is characterized by the accumulation of senescent cells that release proinflammatory cytokines, chemokines and other mediators that lead to inflammatory microenvironments in many tissues and organs ( Bruserud et al, 2022 ). Moreover, CRP level is correlated to the endothelial dysfunction and may reflect the development of atherosclerosis ( Della Corte et al, 2016 ; Maio et al, 2021 ). These evidences can explain the correlation between CRP and risk of cardiovascular and malignancy related morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Serum high-sensitive C-reactive protein is a simple indicator for all-cause among individuals with MAFLD

Huang

Wang

et al. 2022

Front. Physiol.

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High-sensitive C-reactive protein (hs-CRP) is one of the diagnostic components for metabolic (-dysfunction) associated fatty liver disease (MAFLD). This study aimed to explore the relationship between hs-CRP level and 25-year mortality in patients with MAFLD. The study data were from the Third National Health and Nutrition Examination Survey 1988–1994. All participants were followed up until December 2015 and the outcome of each participant was ascertained from National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence interval (CI) of all-cause mortality, cardiovascular-related mortality, and malignancy-related mortality. A total of 4,145 participants with MAFLD were included in final analysis. The median follow-up period was 22.3 years (interquartile range 16.9–24.2). There were 1,610 (38.8%) all-cause deaths. The leading cause of death was malignant neoplasms (365/1,610, 22.7%), followed by cardiovascular diseases (342/1,610, 21.2%). Of the 4,145 patients with MAFLD, 1,293 (31.2%) had an hs-CRP level greater than 0.5 mg/dl. Those with hs-CRP > 0.5 mg/dl were older, more likely to be female and had greater derangements of metabolic profiles than those with lower hs-CRP. The results of Cox regression analysis showed that hs-CRP ≥ 0.5 mg/dl was an independent risk factor for all-cause mortality (HR = 1.394, 95% CI 1.253–1.551), cardiovascular mortality (HR = 1.497, 95% CI 1.190–1.885) and malignant neoplasms related mortality (HR = 1.290, 95% CI 1.030–1.615) after adjusting for risk factors. This study confirms that hs-CRP is an independent predictive factor of poor prognosis in patients with MAFLD.

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Endothelial dysfunction and C‐reactive protein predict the incidence of heart failure in hypertensive patients

Cited by 22 publications

References 35 publications

Serum autotaxin as a novel prognostic marker in patients with non‐ischaemic dilated cardiomyopathy

Serum autotaxin as a novel prognostic marker in patients with non‐ischaemic dilated cardiomyopathy

Integration of RNA molecules data with prior-knowledge driven Joint Deep Semi-Negative Matrix Factorization for heart failure study

Serum high-sensitive C-reactive protein is a simple indicator for all-cause among individuals with MAFLD

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