Endothelial barrier integrity in COVID-19-dependent hyperinflammation: does the protective facet of platelet function matter?

Smęda, Marta; Chłopicki, Stefan

doi:10.1093/cvr/cvaa190

Cited by 29 publications

(20 citation statements)

References 15 publications

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“…Therefore, the greatest risk will have been exhibited by the oldest and most frail patients. Underlying mechanisms for increased mortality with age and frailty with COVID-19 may include endothelial dysfunction leading to vasoconstriction and organ dysfunction ( 25 , 26 ), heightened inflammation ( 27 ) and pro-coagulant state ( 25 , 26 , 28 ), dysregulated angiotensin-converting enzyme 2 activity promoting viral uptake ( 28–30 ) and immunesenescence ( 28 ). Immunesenescence is associated with immune system changes that are age-related ( 31 , 32 ), frailty-related ( 33 ), or inactivity-related ( 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study

Alsahab¹,

Brown²,

Burton³

et al. 2021

Age and Ageing

134

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Introduction Increased mortality has been demonstrated in older adults with COVID-19, but the effect of frailty has been unclear. Methods This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty, and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation, and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS), and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, IQR 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 vs 18–49: HR 3.57, CI 2.54–5.02), frailty (CFS 8 vs 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease, and cancer, but not delirium. Age, frailty (CFS 7 vs 1–3: OR 7.00, CI 5.27–9.32), delirium, dementia, and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusions Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.

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Section: Discussionmentioning

confidence: 99%

Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study

Alsahab¹,

Brown²,

Burton³

et al. 2021

Age and Ageing

134

View full text Add to dashboard Cite

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“…Finally, experiments have revealed that glutathione peroxidase controls thromboxane production, by affecting peroxide formation [55] . A recent hypothesis is that In view of the effect of Se on platelet glutathione peroxidase activity and platelet redox status, the thromboxane metabolic pathway [55] and, consequently, platelet activation [54] , [53] , it is reasonable to propose that impairment in selenocysteine synthesis may be implicated in some of these alterations in platelets’ functions [56] .…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients

2021

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“…Finally, in COVID-19 infection, the platelets, in addition to their prothrombotic action mediated by classical platelet receptors, also have a platelet receptor-mediated hemostatic effect with an important role in the endothelial barrier protection and micro-vascular integrity (18).…”

Section: Highlightsmentioning

confidence: 99%

Thrombosis, an important piece in the COVID-19 puzzle: From pathophysiology to therapy

Bobescu¹,

Marceanu²,

Covaciu³

et al. 2021

Anatolian J Cardiol

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A lot of data about coronavirus disease 2019 (COVID-19) have been already published; however, these still form only a part of the pandemic puzzle. Once we have all the pieces of the puzzle, we will be able to successfully treat this disease with its multiple challenges. COVID-19 has a high thrombogenic potential. In this study, we aimed to review published data about COVID-19 associated thrombosis from pathophysiology to treatment and the role in patient evolution. We searched for articles and studies published online through MEDLINE/PubMed database, Google Scholar, ScienceDirect, Wiley Online Library, and Nature Public Health Emergency Collection. We found numerous articles regarding COVID-19 infection but selected only those focused on thrombosis. D-dimers have a predictive value in identifying thrombosis and a high level correlates with the severity of the infection and death. Most patients who were on chronic anticoagulant therapy before contracting the virus had a better prognosis. Heparin has other favorable effects such as a direct antiviral and anti-inflammatory effect in addition to its anticoagulant effect. COVID-19 infections are frequently complicated by thrombotic pathology. High plasma level of D-dimers is a predictive factor for severe prognosis, and the recommended anticoagulant, associated with low mortality, is heparin followed by a direct oral anticoagulant. Randomized studies in large groups of patients and therapeutic guidelines are still needed on this subject.

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Endothelial barrier integrity in COVID-19-dependent hyperinflammation: does the protective facet of platelet function matter?

Cited by 29 publications

References 15 publications

Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study

Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study

Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients

Thrombosis, an important piece in the COVID-19 puzzle: From pathophysiology to therapy

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