2020
DOI: 10.1038/s41598-019-57234-9
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: constant metabolic demand organ 15 (consuming 20% of the body), endothelium damage and decreased microcirculation might lead to poor perfusion of brain tissue, which could cause death of other cells (including neurons and glial cells) within the neurovascular unit. Varies animal models have been applied to study the radiation induced vascular damage, they found that radiation therapy could induce dose-dependent endothelial apoptosis 16 , disruption of the blood-brain barrier 17 , vascular rarefaction, and cogn… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
7
0

Year Published

2020
2020
2022
2022

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 9 publications
(7 citation statements)
references
References 41 publications
(36 reference statements)
0
7
0
Order By: Relevance
“…To further evaluate the success of SCI model generated, we applied two transgenic lines Tg(gfap:GFP) and Tg(huc:mCherry) for imaging analysis, which express green fluorescent protein (GFP) in radial glia and mCherry in neurons, respectively (Ai et al., 2020; Bernardos et al., 2007). The spinal cords were completely transected, as shown by confocal imaging at 1 dpi (Figure 1b,d).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…To further evaluate the success of SCI model generated, we applied two transgenic lines Tg(gfap:GFP) and Tg(huc:mCherry) for imaging analysis, which express green fluorescent protein (GFP) in radial glia and mCherry in neurons, respectively (Ai et al., 2020; Bernardos et al., 2007). The spinal cords were completely transected, as shown by confocal imaging at 1 dpi (Figure 1b,d).…”
Section: Resultsmentioning
confidence: 99%
“…Transgenic zebrafish Tg(gfap:GFP) and Tg(huc:mCherry) (zfin: nia02Tg) (Ai et al., 2020; Bernardos et al., 2007) were provided by the Zebrafish Core Facility in Nantong University. Feeding and embryo collections were conducted in accordance with standard methods (Snider & Clegg, 1975).…”
Section: Methodsmentioning
confidence: 99%
“…In live zebrafish larvae, radiation can cause acute cerebral capillary constriction and blood‐flow obstruction, leading to cerebral hypoxia (Ai et al, 2020). Evaluation of the role of blood flow in the development of zebrafish breakdance mutants ( bre ) has revealed that reduced blood flow results in significantly increased protein expression of hypoxia inducible factor 1 (HIF)‐α, resulting in a low‐oxygen molecular signal (Kopp et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…Previous study have revealed that Sit-induced autophagy has protective effects on endothelial dysfunction ( Wang et al., 2018 ). However, autophagy has two functions; either keeping the cells survived through degrades some substances inside the cell and or directly participating in various forms of cell death ( Ai et al., 2020 ). A few studies have confirmed that autophagy is detrimental during reperfusion and excessive autophagy destroys essential components resulting in premature cell death ( Matsui et al., 2007 ; Mankarious et al., 2016 ).…”
Section: Discussionmentioning
confidence: 99%