Endosulfan induces small but significant changes in the levels of noradrenaline, dopamine and serotonin in the developing rat brain and deficits in the operant learning performance

Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis

“…Endosulfan induced a significantly higher level of serotonin, reaching up to 200 ng g À1 . This observation is in agreement with several other studies conducted on vertebrates (Paul et al, 1994;Lakshmana and Raju, 1994;Cabaleiro et al, 2008). Cabaleiro et al (2008) suggested that the effects of endosulfan on serotonin concentrations in rat brain could be caused by a direct action on the brain, as endosulfan can cross the hemato-encephalic barrier.…”

Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis

“…Endosulfan induced a significantly higher level of serotonin, reaching up to 200 ng g À1 . This observation is in agreement with several other studies conducted on vertebrates (Paul et al, 1994;Lakshmana and Raju, 1994;Cabaleiro et al, 2008). Cabaleiro et al (2008) suggested that the effects of endosulfan on serotonin concentrations in rat brain could be caused by a direct action on the brain, as endosulfan can cross the hemato-encephalic barrier.…”

New Approach Methodologies and Open Access Tools Help Characterize Risks for DART , DNT , or Endocrine Effects From Exposure to Hallucinogens With Potential Pesticide Contaminants

“…There is evidence from in vivo and NAMs data available through the CTCD and other sources described in this work that CPF/CPO and ENDO also have effects on the thyroid (Juberg et al 2013;Leemans et al 2019;Li et al 2019;Shadani et al 2024; In addition to thyroid endpoints, PSC and CPF were both active with CYP2C9, which is modulated by 5-HT (Gervasini et al 2001;LLerena et al 2003). Each chemical affects the serotonergic pathway, which again shows the potential for overlapping pathways between chemicals with different MOAs (Gervasini et al 2001;Lakshmana and Raju 1994;LLerena et al 2003). Moreover, the SHH assay was active with both PSC and ENDO, and co-exposure could disrupt this protein affecting embryonic development during organogenesis and other processes (El Shahawy et al 2019).…”

Endosulfan’s Effects: Saiyed’s Response

“…We suggested a possible link between endosulfan exposure and these problems, which has been reported in a number of published animal experimental studies, for example, endosulfan-related birth defects (Food Machinery and Chemical Corporation 1980; García-Rodríguez et al 1996; Gupta et al 1978]; scholastic development (Lakshmana and Raju 1994; Paul et al 1994); and reproductive effects in males (Dalsenter et al 1999; Sinha et al 1997, 2001). We submitted our report to the Registration Committee at their request.…”

“…In our report submitted to the National Human Rights Commission, [ National Institute of Occupational Health (NIOH) 2002 ], we reported a higher prevalence of birth defects in both male and female children, lower mean SMR and serum testosterone levels in male children of similar age, a higher prevalence of scholastic backwardness, and neurobehavioral problems in children who had been exposed to endosulfan through aerial treatment of fields ( NIOH 2002 ). We suggested a possible link between endosulfan exposure and these problems, which has been reported in a number of published animal experimental studies, for example, endosulfan-related birth defects ( Food Machinery and Chemical Corporation 1980 ; García-Rodríguez et al 1996 ; Gupta et al 1978 ]; scholastic development ( Lakshmana and Raju 1994 ; Paul et al 1994 ); and reproductive effects in males ( Dalsenter et al 1999 ; Sinha et al 1997 , 2001 ). We submitted our report to the Registration Committee at their request.…”

Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis

“…Endosulfan induced a significantly higher level of serotonin, reaching up to 200 ng g À1 . This observation is in agreement with several other studies conducted on vertebrates (Paul et al, 1994;Lakshmana and Raju, 1994;Cabaleiro et al, 2008). Cabaleiro et al (2008) suggested that the effects of endosulfan on serotonin concentrations in rat brain could be caused by a direct action on the brain, as endosulfan can cross the hemato-encephalic barrier.…”

New Approach Methodologies and Open Access Tools Help Characterize Risks for DART , DNT , or Endocrine Effects From Exposure to Hallucinogens With Potential Pesticide Contaminants

“…There is evidence from in vivo and NAMs data available through the CTCD and other sources described in this work that CPF/CPO and ENDO also have effects on the thyroid (Juberg et al 2013;Leemans et al 2019;Li et al 2019;Shadani et al 2024; In addition to thyroid endpoints, PSC and CPF were both active with CYP2C9, which is modulated by 5-HT (Gervasini et al 2001;LLerena et al 2003). Each chemical affects the serotonergic pathway, which again shows the potential for overlapping pathways between chemicals with different MOAs (Gervasini et al 2001;Lakshmana and Raju 1994;LLerena et al 2003). Moreover, the SHH assay was active with both PSC and ENDO, and co-exposure could disrupt this protein affecting embryonic development during organogenesis and other processes (El Shahawy et al 2019).…”

Endosulfan’s Effects: Saiyed’s Response

“…We suggested a possible link between endosulfan exposure and these problems, which has been reported in a number of published animal experimental studies, for example, endosulfan-related birth defects (Food Machinery and Chemical Corporation 1980; García-Rodríguez et al 1996; Gupta et al 1978]; scholastic development (Lakshmana and Raju 1994; Paul et al 1994); and reproductive effects in males (Dalsenter et al 1999; Sinha et al 1997, 2001). We submitted our report to the Registration Committee at their request.…”

“…In our report submitted to the National Human Rights Commission, [ National Institute of Occupational Health (NIOH) 2002 ], we reported a higher prevalence of birth defects in both male and female children, lower mean SMR and serum testosterone levels in male children of similar age, a higher prevalence of scholastic backwardness, and neurobehavioral problems in children who had been exposed to endosulfan through aerial treatment of fields ( NIOH 2002 ). We suggested a possible link between endosulfan exposure and these problems, which has been reported in a number of published animal experimental studies, for example, endosulfan-related birth defects ( Food Machinery and Chemical Corporation 1980 ; García-Rodríguez et al 1996 ; Gupta et al 1978 ]; scholastic development ( Lakshmana and Raju 1994 ; Paul et al 1994 ); and reproductive effects in males ( Dalsenter et al 1999 ; Sinha et al 1997 , 2001 ). We submitted our report to the Registration Committee at their request.…”

Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis

“…Endosulfan induced a significantly higher level of serotonin, reaching up to 200 ng g À1 . This observation is in agreement with several other studies conducted on vertebrates (Paul et al, 1994;Lakshmana and Raju, 1994;Cabaleiro et al, 2008). Cabaleiro et al (2008) suggested that the effects of endosulfan on serotonin concentrations in rat brain could be caused by a direct action on the brain, as endosulfan can cross the hemato-encephalic barrier.…”

New Approach Methodologies and Open Access Tools Help Characterize Risks for DART , DNT , or Endocrine Effects From Exposure to Hallucinogens With Potential Pesticide Contaminants

“…There is evidence from in vivo and NAMs data available through the CTCD and other sources described in this work that CPF/CPO and ENDO also have effects on the thyroid (Juberg et al 2013;Leemans et al 2019;Li et al 2019;Shadani et al 2024; In addition to thyroid endpoints, PSC and CPF were both active with CYP2C9, which is modulated by 5-HT (Gervasini et al 2001;LLerena et al 2003). Each chemical affects the serotonergic pathway, which again shows the potential for overlapping pathways between chemicals with different MOAs (Gervasini et al 2001;Lakshmana and Raju 1994;LLerena et al 2003). Moreover, the SHH assay was active with both PSC and ENDO, and co-exposure could disrupt this protein affecting embryonic development during organogenesis and other processes (El Shahawy et al 2019).…”

Endosulfan’s Effects: Saiyed’s Response

“…We suggested a possible link between endosulfan exposure and these problems, which has been reported in a number of published animal experimental studies, for example, endosulfan-related birth defects (Food Machinery and Chemical Corporation 1980; García-Rodríguez et al 1996; Gupta et al 1978]; scholastic development (Lakshmana and Raju 1994; Paul et al 1994); and reproductive effects in males (Dalsenter et al 1999; Sinha et al 1997, 2001). We submitted our report to the Registration Committee at their request.…”

“…In our report submitted to the National Human Rights Commission, [ National Institute of Occupational Health (NIOH) 2002 ], we reported a higher prevalence of birth defects in both male and female children, lower mean SMR and serum testosterone levels in male children of similar age, a higher prevalence of scholastic backwardness, and neurobehavioral problems in children who had been exposed to endosulfan through aerial treatment of fields ( NIOH 2002 ). We suggested a possible link between endosulfan exposure and these problems, which has been reported in a number of published animal experimental studies, for example, endosulfan-related birth defects ( Food Machinery and Chemical Corporation 1980 ; García-Rodríguez et al 1996 ; Gupta et al 1978 ]; scholastic development ( Lakshmana and Raju 1994 ; Paul et al 1994 ); and reproductive effects in males ( Dalsenter et al 1999 ; Sinha et al 1997 , 2001 ). We submitted our report to the Registration Committee at their request.…”