Endostatin as a Mediator Between Endothelial Function and Cognitive Performance in Those at Risk for Vascular Cognitive Impairment

Abstract

Background: Patients with coronary artery disease have an increased risk for developing vascular cognitive impairment. Endothelial function is often diminished and has been associated with lower cognitive performance in these patients. The link between endothelial function and cognition in coronary artery disease is not fully understood. Angiogenesis may play a role in mediating the association between endothelial function and cognition since angiogenic processes rely heavily on the endothelium. Objective: The aim of this study was to determine if markers of angiogenesis mediate the relationship between endothelial function and cognition in coronary artery disease patients. Methods: In 50 participants with coronary artery disease, endothelial function was assessed using peripheral arterial tonometry. Vascular endothelial growth factor (pro-angiogenic) and endostatin (anti-angiogenic) were measured in peripheral serum samples. Cognition was assessed using the Montreal Cognitive Assessment. A mediation analysis, using a bias corrected inferential bootstrapping method with 10,000 permutations, was used to determine if vascular endothelial growth factor or endostatin mediated an association between peripheral arterial tonometry measures and cognitive performance on the Montreal Cognitive Assessment. Results: Endostatin, but not vascular endothelial growth factor, mediated a relationship between endothelial function and cognitive performance when controlling for total years of education, body mass index, coronary artery bypass graft, stent, diabetes, and diuretic use. This analysis was also significant when delayed recall was substituted for the overall score on the Montreal Cognitive Assessment. Conclusion: These results suggest that endostatin mediates an association between endothelial function and cognitive performance in coronary artery disease.

Lower glomerular filtration rate after mild stroke induces cognitive impairment by causing endothelial dysfunction

“…Moreover, ED is an early feature of cerebral small vessel disease, which has prognostic significance for cerebrovascular disease in vascular event recurrence and vascular cognitive impairment 31 . Therefore, the occurrence of PSCI may be closely related to ED 32 .In our study, we explored the correlation between ED after MIS and cognitive impairment at 3 months, and found RHI was an independent factor affecting the occurrence of PSCI. At the same time, the area under the curve for the diagnosis of PSCI is more than 0.7, and it also has high sensitivity and specificity.…”

Lower Glomerular Filtration Rate After Mild Stroke Induces Cognitive Impairment by Causing Endothelial Dysfunction

“…Moreover, ED is an early feature of cerebral small vessel disease, which has prognostic signi cance for cerebrovascular disease in vascular event recurrence and vascular cognitive impairment 31 . Therefore, the occurrence of PSCI may be closely related to ED 32 .In our study, we explored the correlation between ED after MIS and cognitive impairment at 3 months, and found RHI was an independent factor affecting the occurrence of PSCI. At the same time, the area under the curve for the diagnosis of PSCI is more than 0.7, and it also has high sensitivity and speci city.…”

Early therapeutic effects of an Angiopoietin-1 mimetic peptide in middle-aged rats with vascular dementia

“…A key role of endostatin in angiogenesis is preventing endothelial cell multiplication, migration, binding, and survival ( Dhanabal et al, 1999 ; Dixelius et al, 2000 ). Endostatin, but not vascular endothelial growth factor was found to mediate a relationship between endothelial function and cognitive performance in patients with coronary artery disease ( Isaacs-Trepanier et al, 2020 ). Activated endothelial cells up-regulate the expression of adhesion molecules and selectins.…”