Endoscopic Sleeve Gastroplasty Alters Gastric Physiology and Induces Loss of Body Weight in Obese Individuals

Dayyeh, Barham K. Abu; Acosta, Andrés; Camilleri, Michael; Mundi, Manpreet S.; Rajan, Elizabeth; Topazian, Mark D.; Gostout, Christopher J.

doi:10.1016/j.cgh.2015.12.030

Cited by 217 publications

(163 citation statements)

References 25 publications

(55 reference statements)

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“…In the first series reported, using the older model, three isolated complications were encountered (perigastric collection, lung embolism, pneumothorax), which were solved with medical treatment (30). No other complications have been reported in the other series reported so far (31)(32)(33)(34)(35), nor regarding the initial experience of 55 cases in our series.…”

Section: Discussionmentioning

confidence: 69%

Multicenter study on the safety of bariatric endoscopy

Coll¹,

Durán²,

Breviere³

et al. 2017

Rev Esp Enferm Dig

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Section: Discussionmentioning

confidence: 69%

Multicenter study on the safety of bariatric endoscopy

Coll¹,

Durán²,

Breviere³

et al. 2017

Rev Esp Enferm Dig

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“…In IGP, there is rather a delaying in gastric emptying caused by the shortening of the stomach and the impaired motility due to the sutures. In fact, in a recent study evaluating postoperative scintigraphic findings on patients submitted to endoscopic sleeve gastroplasty, Abu Dayyeh reported a delayed gastric emptying, recognizing a complete different mechanism of action of this therapy, if compared with SG, where on the contrary a rapid gastric emptying is expected 25 . …”

Section: Discussionmentioning

confidence: 99%

New Technique for Obesity Surgery: Internal Gastric Plication Technique Using Intragastric Single-Port (Igs-Igp) in Experimental Model

Müller

Fikatas

Gül

et al. 2017

ABCD, arq. bras. cir. dig.

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Background: Bariatric surgery is currently the most effective method to ameliorate co-morbidities as consequence of morbidly obese patients with BMI over 35 kg/m2. Endoscopic techniques have been developed to treat patients with mild obesity and ameliorate comorbidities, but endoscopic skills are needed, beside the costs of the devices. Aim:To report a new technique for internal gastric plication using an intragastric single port device in an experimental swine model. Methods: Twenty experiments using fresh pig cadaver stomachs in a laparoscopic trainer were performed. The procedure was performed as follow in ten pigs: 1) volume measure; 2) insufflation of the stomach with CO2; 3) extroversion of the stomach through the simulator and installation of the single port device (Gelpoint Applied Mini) through a gastrotomy close to the pylorus; 4) performance of four intragastric handsewn 4-point sutures with Prolene 2-0, from the gastric fundus to the antrum; 5) after the performance, the residual volume was measured. Sleeve gastrectomy was also performed in further ten pigs and pre- and post-procedure gastric volume were measured. Results: The internal gastric plication technique was performed successfully in the ten swine experiments. The mean procedure time was 27±4 min. It produced a reduction of gastric volume of a mean of 51%, and sleeve gastrectomy, a mean of 90% in this swine model. Conclusion: The internal gastric plication technique using an intragastric single port device required few skills to perform, had low operative time and achieved good reduction (51%) of gastric volume in an in vitro experimental model.

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“…In 2012, Thompson and Hawes reported the first human case of endoscopic sleeve gastrectomy (ESG) [24]. Possible mechanisms of action of EGS are decreased ghrelin without significant changes in peptide tyrosine tyrosine (PYY) or glucagon-like peptide 1 (GLP-1) levels, delayed gastric emptying and increased satiation, similar with laparoscopic sleeve gastroplasty [25]. This procedure was later modified to include medial interrupted reinforcing sutures based on the work of Abu Dayyeh et al, which reported a series of 4 patients who underwent a version of ESG using 2 rows of interrupted stitches [26].…”

Section: Obesitymentioning

confidence: 99%

Endoscopic Accessories Used for More Advanced Endoluminal Therapeutic Procedures

Lee

2017

Clin Endosc

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Endoscopic accessories describe an extensive variety of auxiliary instruments used for diagnostic and therapeutic endoscopy. Various endoscopic accessories have been developed over the previous few decades and are mostly used for treating neoplastic lesions, such as early gastrointestinal (GI) carcinomas and premalignant lesions. Because of extensive research on natural orifice endoluminal surgery (NOTES) in the early 2000s and recent technological developments, new devices have been developed for various advanced endoluminal therapeutic procedures. In particular, a remarkable development of endoscopic management was achieved in the field of gastroesophageal reflux disease (GERD) and obesity. In both conditions, there is treatment gap between medical and surgical therapy. A large proportion of the patients who do not respond to medical treatment and lifestyle modification, still hesitate to directly undergo surgical treatment. To bridge this gap, endoscopic management has been receiving increasing attention. In this article, I review endoscopic and/or endoluminal devices used for the treatment of GERD and obesity with proposed mechanisms of their function.

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Endoscopic Sleeve Gastroplasty Alters Gastric Physiology and Induces Loss of Body Weight in Obese Individuals

Abstract: ESG delays gastric emptying, induces early satiation, and significantly reduces body weight. ESG could be an alternative to bariatric surgery for selected patients with obesity. ClincialTrials.gov number: NCT 01682733.

Cited by 217 publications

References 25 publications

Multicenter study on the safety of bariatric endoscopy

Multicenter study on the safety of bariatric endoscopy

New Technique for Obesity Surgery: Internal Gastric Plication Technique Using Intragastric Single-Port (Igs-Igp) in Experimental Model

Endoscopic Accessories Used for More Advanced Endoluminal Therapeutic Procedures

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